PMID- 36246026
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221019
IS  - 2345-4644 (Print)
IS  - 2345-461X (Electronic)
IS  - 2345-461X (Linking)
VI  - 10
IP  - 9
DP  - 2022 Sep
TI  - Newly Released Advances in the Molecular Mechanisms of Osseous Metastasis and 
      Potential Therapeutic Strategies.
PG  - 741-755
LID - 10.22038/ABJS.2022.57856.2865 [doi]
AB  - The appearance of bone metastases (BM) in individuals with advanced solid cancers 
      (breast, prostate, lung) often worsens their quality of life and prognosis. 
      Although none have been fully effective, several strategies have been used to 
      combat BM. Hence, the need for new data that could be useful for treating bone 
      metastasis. To this end, we reviewed the recent literature on the subject. About 
      patients with prostate cancer, treatments with PIP5K1alpha inhibitors have been found 
      to inhibit tumor invasion and metastasis, and G protein-coupled receptor class C 
      group 5 member A (GPRC5A) could be a future therapeutic target. Regarding 
      patients with breast cancer, we found the following: Asperolide A could be 
      another curative drug; targeting transforming growth factor-beta (TGFbeta) and bone 
      morphogenetic protein (BMP) signaling pathways, along with osteoclast activity, 
      could be a favorable therapeutic approach in the preclusion of osteolytic bone 
      destruction; TRAF6 inhibitors such as 6877002 appear promising; aiming the 
      BMP4-SMAD7 signaling axis is an innovative therapeutic approach; there is 
      favorable proof for the plausible therapeutic utilization of bone aiming 
      immunostimulatory MOF (BT-isMOF) nanoparticles, and inhibition of IL4R and 
      macrophages could have therapeutic benefits. For lung cancer, the function of 
      LIGHT in osteolytic osseous illness instigated by metastatic non-small cell lung 
      cancer should be highlighted.
FAU - Rodriguez-Merchan, E Carlos
AU  - Rodriguez-Merchan EC
AD  - Department of Orthopedic Surgery, La Paz University Hospital-IdiPaz, Madrid, 
      Spain.
FAU - Peleteiro-Pensado, Manuel
AU  - Peleteiro-Pensado M
AD  - Department of Orthopedic Surgery, La Paz University Hospital-IdiPaz, Madrid, 
      Spain.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Iran
TA  - Arch Bone Jt Surg
JT  - The archives of bone and joint surgery
JID - 101636743
PMC - PMC9527427
OTO - NOTNLM
OT  - Bone
OT  - Breast cancer
OT  - Lung cancer
OT  - Metastasis
OT  - Prostate cancer
EDAT- 2022/10/18 06:00
MHDA- 2022/10/18 06:01
PMCR- 2022/09/01
CRDT- 2022/10/17 04:24
PHST- 2021/05/19 00:00 [received]
PHST- 2022/02/15 00:00 [accepted]
PHST- 2022/10/17 04:24 [entrez]
PHST- 2022/10/18 06:00 [pubmed]
PHST- 2022/10/18 06:01 [medline]
PHST- 2022/09/01 00:00 [pmc-release]
AID - 10.22038/ABJS.2022.57856.2865 [doi]
PST - ppublish
SO  - Arch Bone Jt Surg. 2022 Sep;10(9):741-755. doi: 10.22038/ABJS.2022.57856.2865.