PMID- 36248651
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221019
IS  - 1662-4548 (Print)
IS  - 1662-453X (Electronic)
IS  - 1662-453X (Linking)
VI  - 16
DP  - 2022
TI  - Enhanced effective connectivity from the middle frontal gyrus to the parietal 
      lobe is associated with impaired mental rotation after total sleep deprivation: 
      An electroencephalogram study.
PG  - 910618
LID - 10.3389/fnins.2022.910618 [doi]
LID - 910618
AB  - Sleep deprivation impairs cognitive functions, including attention, memory, and 
      decision-making. Studies on the neuro-electro-physiological mechanisms underlying 
      total sleep deprivation (TSD) that impairs spatial cognition are limited. Based 
      on electroencephalogram (EEG) and Exact Low Resolution Brain Electromagnetic 
      Tomography (eLORETA), this study focused on the effects of TSD on mental rotation 
      and the cognitive neural mechanisms underlying its damage. Twenty-four healthy 
      college students completed mental rotation tasks while resting and after 36 h of 
      TSD; their EEG data were simultaneously recorded. The amplitude of P300 component 
      associated with mental rotation was observed and localized through source 
      reconstruction, while changes in effective connectivity between multiple brain 
      regions associated with mental rotation cognitive processing were calculated 
      using isolated effective coherence (iCoh) of eLORETA. Compared with the baseline 
      before TSD, the amplitude of the P300 component related to mental rotation 
      decreased. The task-state data of P300 were localized to the source of the 
      difference in ERP current density, and it was found that the brain regions 
      related to the difference in the decrease in P300 amplitude included the superior 
      parietal lobule, precuneus, prefrontal lobe, and other related regions. Effective 
      connectivity analysis found that TSD enhanced the effective connectivity from the 
      left middle frontal gyrus to the left superior parietal lobule, left inferior 
      parietal lobule, and left precuneus under the identical condition. Pearson 
      correlation analysis showed a positive correlation between the decrease in 
      accuracy of mental rotation and increase in effective connectivity. Thus, our 
      study suggests that TSD impairs the ability of the mental rotation, showing a 
      decrease in P300 amplitude and an enhanced effective connectivity between the 
      middle frontal gyrus and the parietal lobe in the task state.
CI  - Copyright (c) 2022 Li, Ma, Shao and Wang.
FAU - Li, Yutong
AU  - Li Y
AD  - School of Psychology, Beijing Sport University, Beijing, China.
FAU - Ma, Mengke
AU  - Ma M
AD  - School of Psychology, Beijing Sport University, Beijing, China.
FAU - Shao, Yongcong
AU  - Shao Y
AD  - School of Psychology, Beijing Sport University, Beijing, China.
FAU - Wang, Wei
AU  - Wang W
AD  - Department of Criminal Psychology, Northwest University of Political Science and 
      Law, Xi'an, China.
LA  - eng
PT  - Journal Article
DEP - 20220930
PL  - Switzerland
TA  - Front Neurosci
JT  - Frontiers in neuroscience
JID - 101478481
PMC - PMC9566834
OTO - NOTNLM
OT  - P300
OT  - effective connectivity
OT  - event-related potentials
OT  - mental rotation
OT  - sleep deprivation
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/10/18 06:00
MHDA- 2022/10/18 06:01
PMCR- 2022/01/01
CRDT- 2022/10/17 05:09
PHST- 2022/04/01 00:00 [received]
PHST- 2022/09/07 00:00 [accepted]
PHST- 2022/10/17 05:09 [entrez]
PHST- 2022/10/18 06:00 [pubmed]
PHST- 2022/10/18 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fnins.2022.910618 [doi]
PST - epublish
SO  - Front Neurosci. 2022 Sep 30;16:910618. doi: 10.3389/fnins.2022.910618. 
      eCollection 2022.