PMID- 36248900
OWN - NLM
STAT- MEDLINE
DCOM- 20221018
LR  - 20221020
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 13
DP  - 2022
TI  - Adipokines as potential biomarkers for type 2 diabetes mellitus in cats.
PG  - 950049
LID - 10.3389/fimmu.2022.950049 [doi]
LID - 950049
AB  - Type 2 diabetes mellitus (T2DM) is no longer only a disease of humans, but also 
      of domestic animals, and it particularly affects cats. It is increasingly thought 
      that because of its unique characteristics, T2DM may belong not only to the group 
      of metabolic diseases but also to the group of autoimmune diseases. This is due 
      to the involvement of the immune system in the inflammation that occurs with 
      T2DM. Various pro- and anti-inflammatory substances are secreted, especially 
      cytokines in patients with T2DM. Cytokines secreted by adipose tissue are called 
      adipokines, and leptin, adiponectin, resistin, omentin, TNF-alpha, and IL-6 have been 
      implicated in T2DM. In cats, approximately 90% of diabetic cases are T2DM. Risk 
      factors include older age, male sex, Burmese breed, presence of obesity, and 
      insulin resistance. Diagnosis of a cat requires repeated testing and is 
      complicated compared to human diagnosis. Based on similarities in the 
      pathogenesis of T2DM between humans and cats, adipokines previously proposed as 
      biomarkers for human T2DM may also serve in the diagnosis of this disease in 
      cats.
CI  - Copyright (c) 2022 Sierawska and Niedzwiedzka-Rystwej.
FAU - Sierawska, Olga
AU  - Sierawska O
AD  - Doctoral School, University of Szczecin, Szczecin, Poland.
AD  - Institute of Biology, University of Szczecin, Szczecin, Poland.
FAU - Niedzwiedzka-Rystwej, Paulina
AU  - Niedzwiedzka-Rystwej P
AD  - Institute of Biology, University of Szczecin, Szczecin, Poland.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220930
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
RN  - 0 (Adipokines)
RN  - 0 (Adiponectin)
RN  - 0 (Biomarkers)
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-6)
RN  - 0 (Leptin)
RN  - 0 (Resistin)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - *Adipokines
MH  - Adiponectin/metabolism
MH  - Animals
MH  - Biomarkers/metabolism
MH  - Cats
MH  - Cytokines
MH  - *Diabetes Mellitus, Type 2/diagnosis/metabolism
MH  - Humans
MH  - Interleukin-6
MH  - Leptin/metabolism
MH  - Male
MH  - Resistin
MH  - Tumor Necrosis Factor-alpha
PMC - PMC9561307
OTO - NOTNLM
OT  - adipokines
OT  - adiponektin
OT  - diabetes mellitus
OT  - feline
OT  - leptin
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/10/18 06:00
MHDA- 2022/10/19 06:00
PMCR- 2022/01/01
CRDT- 2022/10/17 05:14
PHST- 2022/05/22 00:00 [received]
PHST- 2022/09/01 00:00 [accepted]
PHST- 2022/10/17 05:14 [entrez]
PHST- 2022/10/18 06:00 [pubmed]
PHST- 2022/10/19 06:00 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2022.950049 [doi]
PST - epublish
SO  - Front Immunol. 2022 Sep 30;13:950049. doi: 10.3389/fimmu.2022.950049. eCollection 
      2022.