PMID- 36248989 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20221019 IS - 2234-943X (Print) IS - 2234-943X (Electronic) IS - 2234-943X (Linking) VI - 12 DP - 2022 TI - The efficacy and safety of conventional transcatheter arterial chemoembolization combined with PD-1 inhibitor and anti-angiogenesis tyrosine kinase inhibitor treatment for patients with unresectable hepatocellular carcinoma: a real-world comparative study. PG - 941068 LID - 10.3389/fonc.2022.941068 [doi] LID - 941068 AB - AIM: We sought to evaluate the efficacy and safety of conventional transcatheter arterial chemoembolization (cTACE) sequentially combined with systemic treatment by programmed cell death protein 1 (PD-1) inhibitor and anti-angiogenesis tyrosine kinase inhibitor (Anti-angiogenesis TKI) in patients with unresectable hepatocellular carcinoma (HCC). MATERIALS AND METHODS: One hundred and forty-seven advanced HCC patients who received PD-1 inhibitors and TKIs as first-line systemic treatment between August 2019 and April 2021 were collected retrospectively. Fifty-four patients were finally included and divided into cTACE and no-cTACE groups, according to whether cTACE treatment was performed within 8 weeks before systemic treatment. The tumor objective response ratio (ORR), progression-free survival (PFS), overall survival (OS), and adverse events (AEs) were compared between the groups. Significant factors affecting PFS and OS were determined by Cox regression. RESULTS: Thirty-one patients received cTACE followed by systemic treatment and 23 patients received systemic treatment only. The ORRs of the cTACE group were 48.4% (after two cycles of systemic treatment) and 51.6% (after four cycles of systemic treatment), while those of the no-cTACE group were only 17.4% and 21.7%. cTACE patients also had a longer median PFS (11.70 vs. 4.00 months, P = 0.031) and median OS (19.80 vs. 11.6 months, P = 0.006) than no-cTACE patients. Regression analyses indicated that cTACE therapy and Eastern Cooperative Oncology Group performance status were independent risk factors for PFS and OS. AEs by type were similar between the cTACE and no-cTACE groups, except for liver function injury, which was more common among cTACE patients. Fourteen patients suffered with grade 1-2 of rash in 21 patients with objective response, while only 10 patients suffered with rash in 33 patients without objective response, the adjusted hazard ratio (HR) was 4.382 (1.297-14.803). CONCLUSIONS: The combination of cTACE and PD-1 inhibitors and anti-angiogenesis TKIs as therapy significantly improved markers of treatment efficacy, including ORR, PFS, and OS, in unresectable HCC patients, while no more serious AEs recorded in this population compared to those receiving systemic treatment alone. Skin rash might be a predict factor to the efficacy of PD-1 inhibitors and TKI treatment. CI - Copyright (c) 2022 Guo, Zhu, Zhang, Huang, Wang, Shi, Yu, Qiu and Tu. FAU - Guo, Zheng AU - Guo Z AD - Department of Hematology and Oncology, International Cancer Center, Shenzhen Key Laboratory, Hematology Institution of Shenzhen University, Shenzhen University General Hospital, Shenzhen University Health Science Center, Shenzhen University, Shenzhen, China. FAU - Zhu, Huabin AU - Zhu H AD - First school of clinical medicine, Gannan Medical University, Ganzhou, China. FAU - Zhang, Xiufang AU - Zhang X AD - First school of clinical medicine, Gannan Medical University, Ganzhou, China. FAU - Huang, Li AU - Huang L AD - Department of Oncology, First Affiliated Hospital of Gannan Medical University, Ganzhou, China. FAU - Wang, Xiangcai AU - Wang X AD - Department of Oncology, First Affiliated Hospital of Gannan Medical University, Ganzhou, China. FAU - Shi, Huaqiu AU - Shi H AD - Department of Oncology, First Affiliated Hospital of Gannan Medical University, Ganzhou, China. FAU - Yu, Li AU - Yu L AD - Department of Hematology and Oncology, International Cancer Center, Shenzhen Key Laboratory, Hematology Institution of Shenzhen University, Shenzhen University General Hospital, Shenzhen University Health Science Center, Shenzhen University, Shenzhen, China. FAU - Qiu, Yingwei AU - Qiu Y AD - Department of Radiology, Huazhong University of Science and Technology Union Shenzhen Hospital, Shenzhen, China. FAU - Tu, Fuping AU - Tu F AD - Department of Oncology, First Affiliated Hospital of Gannan Medical University, Ganzhou, China. LA - eng PT - Journal Article DEP - 20220929 PL - Switzerland TA - Front Oncol JT - Frontiers in oncology JID - 101568867 PMC - PMC9558003 OTO - NOTNLM OT - PD-1 inhibitor OT - combination OT - conventional transcatheter arterial chemoembolization OT - tyrosine kinase inhibitor OT - unresectable hepatocellular carcinoma COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2022/10/18 06:00 MHDA- 2022/10/18 06:01 PMCR- 2022/01/01 CRDT- 2022/10/17 05:16 PHST- 2022/05/11 00:00 [received] PHST- 2022/09/12 00:00 [accepted] PHST- 2022/10/17 05:16 [entrez] PHST- 2022/10/18 06:00 [pubmed] PHST- 2022/10/18 06:01 [medline] PHST- 2022/01/01 00:00 [pmc-release] AID - 10.3389/fonc.2022.941068 [doi] PST - epublish SO - Front Oncol. 2022 Sep 29;12:941068. doi: 10.3389/fonc.2022.941068. eCollection 2022.