PMID- 36249178
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230328
IS  - 2699-9307 (Electronic)
IS  - 2699-9307 (Linking)
VI  - 2
IP  - 10
DP  - 2022 Oct
TI  - Antiviral Effects of Heparan Sulfate Analogue-Modified Two-Dimensional MXene 
      Nanocomposites on PRRSV and SARS-CoV-2.
PG  - 2200067
LID - 10.1002/anbr.202200067 [doi]
LID - 2200067
AB  - Due to the worldwide impact of viruses such as SARS-CoV-2, researchers have paid 
      extensive attention to antiviral reagents against viruses. Despite extensive 
      research on two-dimensional (2D) transition metal carbides (MXenes) in the field 
      of biomaterials, their antiviral effects have received little attention. In this 
      work, heparan sulfate analogue (sodium 3-mercapto-1-propanesulfonate, MPS) 
      modified 2D MXene nanocomposites (Ti(3)C(2)-Au-MPS) for prevention of viral 
      infection are prepared and investigated using severe acute respiratory syndrome 
      coronavirus 2 (SARS-CoV-2) pseudovirus and porcine reproductive and respiratory 
      syndrome virus (PRRSV) as two model viruses. Ti(3)C(2)-Au-MPS nanocomposites are 
      shown to possess antiviral properties in the different stages of PRRSV 
      proliferation, such as direct interaction with PRRS virions and inhibiting their 
      adsorption and penetration in the host cell. Additionally, Ti(3)C(2)-Au-MPS 
      nanocomposites can strongly inhibit the infection of SARS-CoV-2 pseudovirus as 
      shown by the contents of its reporter gene GFP and luciferase. These results 
      demonstrate the potential broad-spectrum antiviral property of Ti(3)C(2)-Au-MPS 
      nanocomposites against viruses with the receptor of heparin sulfate. This work 
      sheds light on the specific antiviral effects of MXene-based nanocomposites 
      against viruses and may facilitate further exploration of their antiviral 
      applications.
CI  - (c) 2022 The Authors. Advanced NanoBiomed Research published by Wiley-VCH GmbH.
FAU - Tong, Ting
AU  - Tong T
AD  - College of Science College of Resource and Environment State Key Laboratory of 
      Agricultural Microbiology Huazhong Agricultural University Wuhan 430070 P. R. 
      China.
FAU - Tang, Wantao
AU  - Tang W
AD  - College of Science College of Resource and Environment State Key Laboratory of 
      Agricultural Microbiology Huazhong Agricultural University Wuhan 430070 P. R. 
      China.
FAU - Xiao, Shaobo
AU  - Xiao S
AD  - College of Veterinary Medicine State Key Laboratory of Agricultural Microbiology 
      Key Laboratory of Preventive Veterinary Medicine in Hubei Province Huazhong 
      Agricultural University Wuhan 430070 P. R. China.
FAU - Liang, Jiangong
AU  - Liang J
AUID- ORCID: 0000-0002-8210-0210
AD  - College of Science College of Resource and Environment State Key Laboratory of 
      Agricultural Microbiology Huazhong Agricultural University Wuhan 430070 P. R. 
      China.
LA  - eng
PT  - Journal Article
DEP - 20220815
PL  - Germany
TA  - Adv Nanobiomed Res
JT  - Advanced nanobiomed research
JID - 101773117
PMC - PMC9538433
OTO - NOTNLM
OT  - PRRSV
OT  - SARS-CoV-2
OT  - antiviral mechanisms
OT  - heparan sulfate analogues
OT  - two-dimensional MXene nanocomposites
COIS- The authors declare no conflict of interest.
EDAT- 2022/10/18 06:00
MHDA- 2022/10/18 06:01
PMCR- 2022/08/15
CRDT- 2022/10/17 05:19
PHST- 2022/05/16 00:00 [received]
PHST- 2022/07/03 00:00 [revised]
PHST- 2022/10/17 05:19 [entrez]
PHST- 2022/10/18 06:00 [pubmed]
PHST- 2022/10/18 06:01 [medline]
PHST- 2022/08/15 00:00 [pmc-release]
AID - ANBR202200067 [pii]
AID - 10.1002/anbr.202200067 [doi]
PST - ppublish
SO  - Adv Nanobiomed Res. 2022 Oct;2(10):2200067. doi: 10.1002/anbr.202200067. Epub 
      2022 Aug 15.