PMID- 36250147
OWN - NLM
STAT- MEDLINE
DCOM- 20221018
LR  - 20221019
IS  - 1550-2783 (Electronic)
IS  - 1550-2783 (Linking)
VI  - 19
IP  - 1
DP  - 2022
TI  - Effects of carbohydrate and protein supplement strategies on endurance capacity 
      and muscle damage of endurance runners: A double blind, controlled crossover 
      trial.
PG  - 623-637
LID - 10.1080/15502783.2022.2131460 [doi]
AB  - BACKGROUND: The purpose of this study is to explore the effect of carbohydrate 
      only or carbohydrate plus protein supplementation on endurance capacity and 
      muscle damage. METHODS: Ten recreationally active male runners (VO(2max): 
      53.61 +/- 3.86 ml/kg.min) completed run-to-exhaustion test three times with 
      different intakes of intervention drinks. There was a 7-day wash-out period 
      between tests. Each test started with 60 minutes of running at 70% VO(2max) 
      (phase 1), followed by an endurance capacity test: time-to-exhaustion running at 
      80% VO(2max) (phase 2). Participants randomly ingested either 1) 0.4 g/kg BM 
      carbohydrate before phase 1 and before phase 2 (CHO+CHO), 2) 0.4 g/kg BM protein 
      before phase 1 and 0.4 g/kg BM carbohydrate before phase 2 (PRO+CHO), or 3) 
      0.4 g/kg BM carbohydrate before phase 1 and 0.4 g/kg BM protein before phase 2 
      (CHO+PRO). All subjects ingested carbohydrate (CHO) 1.2 g/kg BM during phase 1, 
      and blood samples were obtained before, immediately, and 24 h after exercise for 
      measurements of alanine aminotransferase (ALT), aspartate aminotransferase (AST), 
      creatine kinase (CK), and myoglobin (MB). RESULTS: There was no significant 
      difference in time to exhaustion between the three supplement strategies 
      (CHO+CHO: 432 +/- 225 s; PRO+CHO: 463 +/- 227 s; CHO+PRO: 461 +/- 248 s). However, ALT 
      and AST were significantly lower in PRO+CHO than in CHO+CHO 24 h after exercise 
      (ALT: 16.80 +/- 6.31 vs. 24.39 +/- 2.54 U/L; AST: 24.06 +/- 4.77 vs. 31.51 +/- 7.53 U/L, 
      p < 0.05). MB was significantly lower in PRO+CHO and CHO+PRO than in CHO+CHO 24 h 
      after exercise (40.7 +/- 15.2; 38.1 +/- 14.3; 64.3 +/- 28.9 ng/mL, respectively, p 
      < 0.05). CK increased less in PRO+CHO compared to CHO+CHO 24 h after exercise 
      (404.22 +/- 75.31 VS. 642.33 +/- 68.57 U/L, p < 0.05). CONCLUSION: Carbohydrate and 
      protein supplement strategies can reduce muscle damage caused by endurance 
      exercise, but they do not improve endurance exercise capacity.
CI  - (c) 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & 
      Francis Group.
FAU - Liang, Yiheng
AU  - Liang Y
AUID- ORCID: 0000-0003-3259-2365
AD  - Department of Exercise Biochemistry, Exercise Science School, Beijing Sport 
      University, Beijing, Peking, China.
FAU - Chen, Yan
AU  - Chen Y
AD  - Department of Exercise Biochemistry, Exercise Science School, Beijing Sport 
      University, Beijing, Peking, China.
FAU - Yang, Fan
AU  - Yang F
AD  - Department of Exercise Biochemistry, Exercise Science School, Beijing Sport 
      University, Beijing, Peking, China.
FAU - Jensen, Jorgen
AU  - Jensen J
AD  - Department of Exercise Biochemistry, Exercise Science School, Beijing Sport 
      University, Beijing, Peking, China.
AD  - Norwegian School of Sport Sciences, Department of Physical Performance, Oslo, 
      Norway.
FAU - Gao, Ruirui
AU  - Gao R
AD  - Department of Exercise Biochemistry, Exercise Science School, Beijing Sport 
      University, Beijing, Peking, China.
FAU - Yi, Longyan
AU  - Yi L
AD  - Institute of Sport and Health Science, Beijing Sport University, Beijing, Peking, 
      China.
FAU - Qiu, Junqiang
AU  - Qiu J
AUID- ORCID: 0000-0001-8313-9216
AD  - Department of Exercise Biochemistry, Exercise Science School, Beijing Sport 
      University, Beijing, Peking, China.
AD  - Beijing Sports Nutrition Engineering Research Center, Beijing Sport University, 
      Beijing, Peking, China.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20221012
PL  - United States
TA  - J Int Soc Sports Nutr
JT  - Journal of the International Society of Sports Nutrition
JID - 101234168
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Dietary Proteins)
RN  - 0 (Myoglobin)
RN  - EC 2.6.1.1 (Aspartate Aminotransferases)
RN  - EC 2.6.1.2 (Alanine Transaminase)
RN  - EC 2.7.3.2 (Creatine Kinase)
SB  - IM
MH  - Alanine Transaminase/metabolism/pharmacology
MH  - Aspartate Aminotransferases/metabolism/pharmacology
MH  - Creatine Kinase
MH  - Cross-Over Studies
MH  - *Dietary Carbohydrates
MH  - Dietary Proteins
MH  - Double-Blind Method
MH  - Humans
MH  - Male
MH  - Muscle, Skeletal
MH  - Myoglobin
MH  - *Physical Endurance
PMC - PMC9559053
OTO - NOTNLM
OT  - Endurance exercise
OT  - fatigue and recovery
OT  - sports beverage
COIS- No potential conflict of interest was reported by the author(s).
EDAT- 2022/10/18 06:00
MHDA- 2022/10/19 06:00
PMCR- 2022/10/12
CRDT- 2022/10/17 05:35
PHST- 2022/10/17 05:35 [entrez]
PHST- 2022/10/18 06:00 [pubmed]
PHST- 2022/10/19 06:00 [medline]
PHST- 2022/10/12 00:00 [pmc-release]
AID - 2131460 [pii]
AID - 10.1080/15502783.2022.2131460 [doi]
PST - epublish
SO  - J Int Soc Sports Nutr. 2022 Oct 12;19(1):623-637. doi: 
      10.1080/15502783.2022.2131460. eCollection 2022.