PMID- 36250611
OWN - NLM
STAT- MEDLINE
DCOM- 20221215
LR  - 20230415
IS  - 1554-527X (Electronic)
IS  - 0736-0266 (Print)
IS  - 0736-0266 (Linking)
VI  - 41
IP  - 1
DP  - 2023 Jan
TI  - Platelet-rich plasma versus corticosteroid injections in the management of 
      patients with rotator cuff disease: A systematic review and meta-analysis.
PG  - 7-20
LID - 10.1002/jor.25463 [doi]
AB  - Platelet-rich plasma (PRP) is an alternative to corticosteroid (CS) injections in 
      managing rotator cuff disease. This meta-analysis investigated differences 
      between PRP and CS for function and pain scores in significance and minimal 
      clinical important difference (MCID). A literature search of Ovid Cochrane 
      Library, Medline, Embase, Epub, and Scopus was conducted from inception to 
      October 28, 2021. Eligible studies reported patients older than 18 years with a 
      diagnosis of rotator cuff disease. This review was registered in PROSPERO (ID: 
      CRD42021278740). Twelve studies met eligibility criteria (n = 639) of patients 
      receiving either PRP or CS. At short-term follow-up, a difference favored CS 
      compared to PRP in baseline change for disability of arm, shoulder, and hand 
      (DASH) score (MD = -5.08, 95% CI: -8.00, -2.15; p = 0.0007; I(2)  = 0%) and 
      simple shoulder test (SST) (MD = 1.25, 95% CI: 0.33, 2.18; p = 0.008; I(2) 
       = 0%). At intermediate follow-up, a difference favored PRP to CS baseline change 
      of the DASH score (MD = 3.41, 95% CI: 0.67, 6.15; p = 0.01; I(2)  = 0%). At 
      medium-term, a difference favored PRP to CS baseline change of the American 
      Shoulder and Elbow Surgeons Shoulder (ASES) score (MD = -4.42, 95% CI: -8.16, 
      -0.67; p = 0.02; I(2)  = 0%). Both treatments achieved individual MCID for each 
      score. Despite favoring CS at short-term follow-up and PRP at intermediate- and 
      medium-term follow-up, functional and pain scores did not demonstrate any 
      clinical difference between the two treatment modalities in management of rotator 
      cuff disease at all follow-up periods.
CI  - (c) 2022 The Authors. Journal of Orthopaedic Research(R) published by Wiley 
      Periodicals LLC on behalf of Orthopaedic Research Society.
FAU - Adra, Maamoun
AU  - Adra M
AD  - St George's University of London, London, UK.
AD  - University of Nicosia Medical School, University of Nicosia, Nicosia, Cyprus.
FAU - El Ghazal, Nour
AU  - El Ghazal N
AD  - St George's University of London, London, UK.
AD  - University of Nicosia Medical School, University of Nicosia, Nicosia, Cyprus.
FAU - Nakanishi, Hayato
AU  - Nakanishi H
AD  - St George's University of London, London, UK.
AD  - University of Nicosia Medical School, University of Nicosia, Nicosia, Cyprus.
FAU - Smayra, Karen
AU  - Smayra K
AD  - St George's University of London, London, UK.
AD  - University of Nicosia Medical School, University of Nicosia, Nicosia, Cyprus.
FAU - Hong, Sam S
AU  - Hong SS
AD  - St George's University of London, London, UK.
AD  - University of Nicosia Medical School, University of Nicosia, Nicosia, Cyprus.
FAU - Miangul, Shahid
AU  - Miangul S
AD  - St George's University of London, London, UK.
AD  - University of Nicosia Medical School, University of Nicosia, Nicosia, Cyprus.
FAU - Matar, Reem H
AU  - Matar RH
AD  - St George's University of London, London, UK.
AD  - University of Nicosia Medical School, University of Nicosia, Nicosia, Cyprus.
AD  - Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, New York, 
      USA.
FAU - Than, Christian A
AU  - Than CA
AUID- ORCID: 0000-0003-4283-7629
AD  - St George's University of London, London, UK.
AD  - University of Nicosia Medical School, University of Nicosia, Nicosia, Cyprus.
AD  - School of Biomedical Sciences, The University of Queensland, Brisbane, 
      Queensland, Australia.
FAU - Tennent, Duncan
AU  - Tennent D
AD  - Orthopedic Department, St George's Hospital, London, UK.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20221031
PL  - United States
TA  - J Orthop Res
JT  - Journal of orthopaedic research : official publication of the Orthopaedic 
      Research Society
JID - 8404726
SB  - IM
MH  - Humans
MH  - *Platelet-Rich Plasma
MH  - Pain
PMC - PMC10092782
OTO - NOTNLM
OT  - corticosteroid
OT  - injection
OT  - meta-analysis
OT  - platelet-rich
OT  - rotator cuff
COIS- The authors declare no conflict of interest.
EDAT- 2022/10/18 06:00
MHDA- 2022/12/15 06:00
PMCR- 2023/04/12
CRDT- 2022/10/17 07:42
PHST- 2022/08/22 00:00 [revised]
PHST- 2022/06/10 00:00 [received]
PHST- 2022/10/08 00:00 [accepted]
PHST- 2022/10/18 06:00 [pubmed]
PHST- 2022/12/15 06:00 [medline]
PHST- 2022/10/17 07:42 [entrez]
PHST- 2023/04/12 00:00 [pmc-release]
AID - JOR25463 [pii]
AID - 10.1002/jor.25463 [doi]
PST - ppublish
SO  - J Orthop Res. 2023 Jan;41(1):7-20. doi: 10.1002/jor.25463. Epub 2022 Oct 31.