PMID- 36252460
OWN - NLM
STAT- MEDLINE
DCOM- 20221207
LR  - 20230208
IS  - 1873-1244 (Electronic)
IS  - 0899-9007 (Linking)
VI  - 105
DP  - 2023 Jan
TI  - Dietary insulin index and load in relation to cardiometabolic risk factors in 
      patients with type 2 diabetes mellitus: A cross-sectional study on the RaNCD 
      cohort study.
PG  - 111830
LID - S0899-9007(22)00243-X [pii]
LID - 10.1016/j.nut.2022.111830 [doi]
AB  - OBJECTIVES: The aim of the present study was to evaluate the link between the 
      dietary insulin index (DII) and dietary insulin load (DIL) and cardiometabolic 
      risk factors in patients with type 2 diabetes mellitus (T2DM). METHOD: In this 
      cross-sectional population-based study, 827 participants with diabetes were 
      included based on the RaNCD (Ravansar Non-Communicable Disease) cohort study 
      baseline data. DII and DIL were calculated based on standard formulas using food 
      insulin index values published earlier. Logistic regression analysis was used to 
      determine the association of DII and DIL with cardiovascular risk factors. 
      RESULTS: A significantly direct association was shown between DII and metabolic 
      syndrome (MetS; odds ratio [OR], 1.32; 95% confidence interval [CI], 1.05-2.50). 
      The odds of developing abdominal obesity in patients with the highest DII were 
      almost twice as high as those with the lowest DII (OR, 2.06; 95% CI, 1.02-4.99). 
      Patients in the top quintile of DIL had twice the odds of being obese than those 
      in the bottom quintile. Furthermore, positive associations were found between DIL 
      and both MetS (OR, 1.98; 95% CI, 1.10-4.21) and waist circumference (OR, 2.90; 
      95% CI, 1.10-7.20). CONCLUSION: Higher DII and DIL were positively related to 
      greater risks for both MetS and abdominal obesity among patients with T2DM. 
      Additionally, higher DIL was associated with a higher risk for obesity in the 
      Ravansar population. However, further prospective investigations are needed to 
      clarify the cause-and-effect link between DII, DIL, and cardiovascular risk 
      factors in patients with T2DM.
CI  - Copyright (c) 2022. Published by Elsevier Inc.
FAU - Anjom-Shoae, Javad
AU  - Anjom-Shoae J
AD  - Adelaide Medical School, Faculty of Health and Medical Sciences, University of 
      Adelaide, Adelaide, Australia.
FAU - Namazi, Nazli
AU  - Namazi N
AD  - Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences 
      Institute, Tehran University of Medical Sciences, Tehran, Iran.
FAU - Ayati, Mohammad Hossein
AU  - Ayati MH
AD  - School of Traditional Medicine, Tehran University of Medical Sciences, Tehran, 
      Iran; Endocrinology and Metabolism Research Center, Endocrinology and Metabolism 
      Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
FAU - Darbandi, Mitra
AU  - Darbandi M
AD  - Research Center for Environmental Determinants of Health (RCEDH), Health 
      Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
FAU - Najafi, Farid
AU  - Najafi F
AD  - Research Center for Environmental Determinants of Health (RCEDH), Health 
      Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran; 
      Cardiovascular Research Center, Kermanshah University of Medical Sciences, 
      Kermanshah, Iran.
FAU - Pasdar, Yahya
AU  - Pasdar Y
AD  - Research Center for Environmental Determinants of Health (RCEDH), Health 
      Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran. 
      Electronic address: yahya.pasdar@kums.ac.ir.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220822
PL  - United States
TA  - Nutrition
JT  - Nutrition (Burbank, Los Angeles County, Calif.)
JID - 8802712
RN  - 0 (Insulin)
SB  - IM
MH  - Humans
MH  - Cross-Sectional Studies
MH  - *Diabetes Mellitus, Type 2/complications/epidemiology
MH  - Insulin
MH  - Cohort Studies
MH  - Cardiometabolic Risk Factors
MH  - Obesity, Abdominal/complications/epidemiology
MH  - Risk Factors
MH  - Diet/adverse effects
MH  - Obesity/etiology
MH  - Inflammation/complications
OTO - NOTNLM
OT  - Cardiovascular disease
OT  - Dietary insulin index
OT  - Persian cohort
OT  - T2DM
COIS- Declaration of Competing Interest Authors declared no conflict of interest.
EDAT- 2022/10/18 06:00
MHDA- 2023/02/09 06:00
CRDT- 2022/10/17 18:30
PHST- 2022/04/05 00:00 [received]
PHST- 2022/07/29 00:00 [revised]
PHST- 2022/08/09 00:00 [accepted]
PHST- 2022/10/18 06:00 [pubmed]
PHST- 2023/02/09 06:00 [medline]
PHST- 2022/10/17 18:30 [entrez]
AID - S0899-9007(22)00243-X [pii]
AID - 10.1016/j.nut.2022.111830 [doi]
PST - ppublish
SO  - Nutrition. 2023 Jan;105:111830. doi: 10.1016/j.nut.2022.111830. Epub 2022 Aug 22.