PMID- 36255024
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221126
IS  - 2303-9027 (Print)
IS  - 2226-7190 (Electronic)
IS  - 2226-7190 (Linking)
VI  - 11
IP  - 5
DP  - 2022 Sep-Oct
TI  - Safety and efficacy of EUS-guided ablation of pancreatic lesions with ethanol 
      versus ethanol with paclitaxel: A systematic review and meta-analysis.
PG  - 371-376
LID - 10.4103/EUS-D-20-00185 [doi]
AB  - BACKGROUND AND OBJECTIVES: EUS-guided ethanol ablation has emerged as an 
      alternative method for pancreatic lesions. Recently, paclitaxel was added to 
      ethanol to assess ablative effects in pancreatic lesions. We performed a 
      systematic review and meta-analysis on EUS-guided ethanol ablation (EUS E) versus 
      EUS-guided ethanol with paclitaxel (EUS EP) ablation for the management of 
      pancreatic lesions. METHODS: Comprehensive search of multiple electronic 
      databases and conference proceedings including PubMed, EMBASE, Google Scholar, 
      and Web of Science databases (from inception to May 2020). The primary outcome 
      evaluated complete ablation of the lesions radiologically and the secondary 
      outcome evaluated adverse events (AEs). RESULTS: Fifteen studies on 524 patients 
      were included in our analysis. The pooled complete ablation rate was 58.89% (95% 
      confidence interval (CI) = 38.72-77.80, I(2) = 91.76%) and 55.99% (95% CI = 
      44.66-67.05, I(2) = 0) in the EUS E and EUS EP groups (P = 0.796), respectively. 
      The pooled AE rates were 13.92% (95% CI = 4.71-26.01, I(2) = 83.43%) and 31.62% 
      (95% CI = 3.36-68.95, I(2) = 87.9%) in the EUS E and EUS EP groups (P = 0.299), 
      respectively. The most common AE was abdominal pain at 7.27% (95% CI = 1.97-14.6, 
      I(2) = 68.2%) and 12.44% (95% CI = 0.00-39.24, I(2) = 81.1%) in the EUS E and EUS 
      EP groups (P = 0.583), respectively. Correlation coefficient (r) was ‒0.719 (P = 
      0.008) between complete ablation and lesion size. CONCLUSION: Complete ablation 
      rates were comparable among both groups. AE rates were higher in the EUS EP 
      group. Further randomized controlled trials are needed to validate our findings.
FAU - Saghir, Syed Mohsin
AU  - Saghir SM
AD  - Department of Internal Medicine, University of Nevada Las Vegas School of 
      Medicine, Las Vegas, Nevada, USA.
FAU - Dhindsa, Banreet Singh
AU  - Dhindsa BS
AD  - Division of Gastroenterology and Hepatology, University of Nebraska Medical 
      Center, Nebraska Medical Center, Omaha, NE, USA.
FAU - Daid, Sarav Gunjit Singh
AU  - Daid SGS
AD  - Department of Internal Medicine, New York Medical College, NYC Health + 
      Hospitals/Metropolitan, New York, NY, USA.
FAU - Naga, Yassin
AU  - Naga Y
AD  - Department of Internal Medicine, University of Nevada Las Vegas School of 
      Medicine, Las Vegas, Nevada, USA.
FAU - Dhaliwal, Amaninder
AU  - Dhaliwal A
AD  - Division of Gastroenterology and Hepatology, Moffitt Cancer Center, Tampa, FL, 
      USA.
FAU - Mashiana, Harmeet S
AU  - Mashiana HS
AD  - Division of Gastroenterology and Hepatology, University of Nebraska Medical 
      Center, Nebraska Medical Center, Omaha, NE, USA.
FAU - Bhogal, Neil
AU  - Bhogal N
AD  - Division of Gastroenterology and Hepatology, University of Nebraska Medical 
      Center, Nebraska Medical Center, Omaha, NE, USA.
FAU - Sayles, Harlan
AU  - Sayles H
AD  - Department of Biostatistics, University of Nebraska Medical Center, Nebraska 
      Medical Center, Omaha, NE, USA.
FAU - Ramai, Daryl
AU  - Ramai D
AD  - Department of Internal Medicine, The Brooklyn Hospital Center, Brooklyn, New 
      York, USA.
FAU - Singh, Shailender
AU  - Singh S
AD  - Division of Gastroenterology and Hepatology, University of Nebraska Medical 
      Center, Nebraska Medical Center, Omaha, NE, USA.
FAU - Bhat, Ishfaq
AU  - Bhat I
AD  - Division of Gastroenterology and Hepatology, University of Nebraska Medical 
      Center, Nebraska Medical Center, Omaha, NE, USA.
FAU - Rangray, Rajani
AU  - Rangray R
AD  - Division of Gastroenterology and Hepatology, CHI Health Creighton University 
      Medical Center, Omaha, NE, USA.
FAU - McDonough, Stephanie
AU  - McDonough S
AD  - Division of Gastroenterology and Hepatology, University of Utah, Salt Lake City, 
      Utah, USA.
FAU - Adler, Douglas G
AU  - Adler DG
AD  - Center for Advanced Therapeutic Endoscopy (CATE), Centura Health, Porter 
      Hospital, Peak Gastroenterology, Denver, Colorado, USA.
LA  - eng
PT  - Journal Article
PL  - China
TA  - Endosc Ultrasound
JT  - Endoscopic ultrasound
JID - 101622292
PMC - PMC9688138
OTO - NOTNLM
OT  - ethanol
OT  - lesions
OT  - meta-analysis
OT  - paclitaxel
OT  - pancreatic
COIS- None
EDAT- 2022/10/19 06:00
MHDA- 2022/10/19 06:01
PMCR- 2021/09/21
CRDT- 2022/10/18 07:14
PHST- 2022/10/18 07:14 [entrez]
PHST- 2022/10/19 06:00 [pubmed]
PHST- 2022/10/19 06:01 [medline]
PHST- 2021/09/21 00:00 [pmc-release]
AID - EndoscUltrasound_2022_11_5_371_326307 [pii]
AID - EUS-11-371 [pii]
AID - 10.4103/EUS-D-20-00185 [doi]
PST - ppublish
SO  - Endosc Ultrasound. 2022 Sep-Oct;11(5):371-376. doi: 10.4103/EUS-D-20-00185.