PMID- 36255486
OWN - NLM
STAT- MEDLINE
DCOM- 20230222
LR  - 20230630
IS  - 1432-1084 (Electronic)
IS  - 0938-7994 (Linking)
VI  - 33
IP  - 3
DP  - 2023 Mar
TI  - Incremental prognostic value of myocardial strain over ventricular volume in 
      patients with repaired tetralogy of Fallot.
PG  - 1992-2003
LID - 10.1007/s00330-022-09166-8 [doi]
AB  - OBJECTIVES: The relative incremental predictive value of myocardial deformation 
      over ventricular volume for future adverse events in patients with repaired 
      tetralogy of Fallot (rTOF) remains unknown. We aimed to determine the incremental 
      prognostic value of myocardial deformation over ventricular volume to predict 
      adverse events in patients with rToF. METHODS: We retrospectively included 
      patients with rTOF who completed cardiac magnetic resonance (CMR) and follow-up 
      in our hospital from January 2014 to October 2020, and stratified according to 
      the presence or absence of adverse events during follow-up. The strain parameters 
      of the right ventricular (RV) and left ventricular (LV) were obtained from 
      CMR-derived feature tracking. Multivariable Cox proportional hazard models and 
      net reclassification improvement analysis were used to analyze the prognostic 
      information of biventricular strain and volume parameters in rTOF patients. 
      RESULTS: Among 98 patients with rTOF, 54 (55.1%) experienced primary and/or 
      secondary events during a median follow-up period of 27.0 months. Univariable 
      analysis indicated that RV volume and strain were significantly associated with 
      both primary events and all adverse events (all p < .01). Multivariable Cox 
      regression and net reclassification improvement analyses achieved incremental 
      global chi(2) (all p < .001), C index (all p < .001), and overall correct 
      reclassification by sequentially adding CMR-derived RV volume, RV strain and LV 
      strain parameters to preexisting clinical factors in adverse events model 
      analyses. CONCLUSIONS: RV and LV myocardial deformation provided incremental 
      prognostic information and significant improvement for risk stratification over 
      RV size and clinical variables and therefore can be combined to further enhance 
      prognostication. KEY POINTS: * RV volume and strain were significantly associated 
      with both primary events and all adverse events, whereas LV volume and strain 
      were associated with primary events. * Ventricular myocardial deformation is a 
      strong predictor of adverse outcomes of patients with repaired tetralogy of 
      Fallot, providing increased prognostic information and significantly improved 
      risk stratification over ventricular size.
CI  - (c) 2022. The Author(s), under exclusive licence to European Society of Radiology.
FAU - Jiang, Li
AU  - Jiang L
AD  - Department of Radiology, Functional and Molecular Imaging Key Laboratory of 
      Sichuan Province, West China Hospital, Sichuan University, 37# Guo Xue Xiang, 
      Chengdu, 610041, Sichuan, China.
FAU - Guo, Ying-Kun
AU  - Guo YK
AD  - Department of Radiology, Key Laboratory of Birth Defects and Related Diseases of 
      Women and Children of Ministry of Education, West China Second University 
      Hospital, Sichuan University, 20# South Renmin Road, Chengdu, Sichuan, China.
FAU - Xu, Hua-Yan
AU  - Xu HY
AD  - Department of Radiology, Key Laboratory of Birth Defects and Related Diseases of 
      Women and Children of Ministry of Education, West China Second University 
      Hospital, Sichuan University, 20# South Renmin Road, Chengdu, Sichuan, China.
FAU - Zhu, Xiao
AU  - Zhu X
AD  - Department of Cardiology, Chengdu First People's Hospital, 18# Wanxiang North 
      Road, Chengdu, Sichuan, China.
FAU - Yan, Wei-Feng
AU  - Yan WF
AD  - Department of Radiology, Functional and Molecular Imaging Key Laboratory of 
      Sichuan Province, West China Hospital, Sichuan University, 37# Guo Xue Xiang, 
      Chengdu, 610041, Sichuan, China.
FAU - Li, Yuan
AU  - Li Y
AD  - Department of Radiology, Functional and Molecular Imaging Key Laboratory of 
      Sichuan Province, West China Hospital, Sichuan University, 37# Guo Xue Xiang, 
      Chengdu, 610041, Sichuan, China.
FAU - Yang, Zhi-Gang
AU  - Yang ZG
AUID- ORCID: 0000-0001-9341-7697
AD  - Department of Radiology, Functional and Molecular Imaging Key Laboratory of 
      Sichuan Province, West China Hospital, Sichuan University, 37# Guo Xue Xiang, 
      Chengdu, 610041, Sichuan, China. yangzg666@163.com.
LA  - eng
GR  - ZYGD18013/1.3.5 project for disciplines of excellence, West China Hospital, 
      Sichuan University/
GR  - 2020YJ0229/Sichuan Province Science and Technology Support Program/
PT  - Journal Article
DEP - 20221018
PL  - Germany
TA  - Eur Radiol
JT  - European radiology
JID - 9114774
SB  - IM
MH  - Humans
MH  - *Tetralogy of Fallot/diagnostic imaging/surgery
MH  - Prognosis
MH  - Retrospective Studies
MH  - Ventricular Function, Left
MH  - *Cardiac Surgical Procedures/adverse effects
MH  - Magnetic Resonance Imaging, Cine
MH  - Ventricular Function, Right
MH  - *Ventricular Dysfunction, Right
OTO - NOTNLM
OT  - Cardiac magnetic resonance imaging
OT  - Myocardial deformation
OT  - Prognostic analysis
OT  - Repaired tetralogy of Fallot
OT  - Ventricular volume
EDAT- 2022/10/19 06:00
MHDA- 2023/02/22 06:00
CRDT- 2022/10/18 11:14
PHST- 2022/04/06 00:00 [received]
PHST- 2022/09/12 00:00 [accepted]
PHST- 2022/07/31 00:00 [revised]
PHST- 2022/10/19 06:00 [pubmed]
PHST- 2023/02/22 06:00 [medline]
PHST- 2022/10/18 11:14 [entrez]
AID - 10.1007/s00330-022-09166-8 [pii]
AID - 10.1007/s00330-022-09166-8 [doi]
PST - ppublish
SO  - Eur Radiol. 2023 Mar;33(3):1992-2003. doi: 10.1007/s00330-022-09166-8. Epub 2022 
      Oct 18.