PMID- 36255496
OWN - NLM
STAT- MEDLINE
DCOM- 20221020
LR  - 20221108
IS  - 1436-5073 (Electronic)
IS  - 0026-3672 (Linking)
VI  - 189
IP  - 11
DP  - 2022 Oct 18
TI  - A "signal-on" photoelectrochemical sensor for human epidermal growth factor 
      receptor 2 detection based on Y6/CdS organic-inorganic heterojunction.
PG  - 425
LID - 10.1007/s00604-022-05489-x [doi]
AB  - A "signal-on" photoelectrochemical (PEC) immunosensor was successfully 
      constructed for determination of human epidermal growth factor receptor 2 (HER2) 
      based on organic-inorganic heterojunction Y6/CdS as photoactive material. 
      Compared with single organic semiconductor, Y6, Y6/CdS exhibited higher 
      photoelectric conversion efficiency due to the formation of heterojunction. In 
      the presence of HER2, sandwich immune structure was formed between HER2 aptamer 
      and anti-HER2 antibody (Ab) by specific recognition. The polydopamine (PDA) 
      nanoparticles were used for signal amplification to enhance photocurrent 
      intensity as PDA can act as electron donor to eliminate holes and promote 
      electron-hole pairs separation. The developed PEC sensor displayed a wide 
      detection range of 5-1000 pg mL(-1) and a low detection limit of 2.2 pg mL(-1) 
      for HER2 (S/N = 3). The sensor was successfully used for the detection of HER2 in 
      serum with recoveries between 94.8 and 104% and relative standard deviations 
      (RSDs) in the range of 1.2-4.3%. Furthermore, the designed immunosensor possessed 
      good stability, selectivity, and reproducibility, which can find potential 
      clinical applications for disease diagnosis. A "signal-on" photoelectrochemical 
      sensor was reported for human epidermal growth factor receptor 2 detection based 
      on Y6/CdS organic-inorganic heterojunction.
CI  - (c) 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, 
      part of Springer Nature.
FAU - Luo, Jiarong
AU  - Luo J
AD  - Hunan Provincial Key Laboratory of Micro & Nano Materials Interface Science, 
      College of Chemistry and Chemical Engineering, Central South University, 
      Changsha, 410083, China.
FAU - Luo, Junjun
AU  - Luo J
AD  - School of Pharmacy, Zunyi Medical University, Zunyi, Guizhou, 563000, China.
FAU - Deng, Lei
AU  - Deng L
AD  - Hunan Provincial Key Laboratory of Micro & Nano Materials Interface Science, 
      College of Chemistry and Chemical Engineering, Central South University, 
      Changsha, 410083, China.
FAU - Yang, Minghui
AU  - Yang M
AUID- ORCID: 0000-0002-7612-8137
AD  - Hunan Provincial Key Laboratory of Micro & Nano Materials Interface Science, 
      College of Chemistry and Chemical Engineering, Central South University, 
      Changsha, 410083, China. yangminghui@csu.edu.cn.
AD  - Department of Dermatology, Xiangya Hospital, Central South University, Changsha, 
      410000, Hunan, China. yangminghui@csu.edu.cn.
AD  - National Engineering Research Center of Personalized Diagnostic and Therapeutic 
      Technology, Central South University, Changsha, 410083, China. 
      yangminghui@csu.edu.cn.
FAU - Chen, Xiang
AU  - Chen X
AD  - School of Pharmacy, Zunyi Medical University, Zunyi, Guizhou, 563000, China. 
      chenxiangck@126.com.
AD  - Department of Dermatology, Xiangya Hospital, Central South University, Changsha, 
      410000, Hunan, China. chenxiangck@126.com.
AD  - National Engineering Research Center of Personalized Diagnostic and Therapeutic 
      Technology, Central South University, Changsha, 410083, China. 
      chenxiangck@126.com.
LA  - eng
GR  - 22174163/National Natural Science Foundation of China/
GR  - 2019TP1001/Hunan Provincial Science and Technology Department/
GR  - TC210804V/Ministry of Industry and Information Technology of the People's 
      Republic of China/
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20221018
PL  - Austria
TA  - Mikrochim Acta
JT  - Mikrochimica acta
JID - 7808782
RN  - 0 (Cadmium Compounds)
RN  - EC 2.7.10.1 (ERBB2 protein, human)
SB  - IM
MH  - Humans
MH  - Electrochemical Techniques
MH  - *Cadmium Compounds/chemistry
MH  - *Biosensing Techniques
MH  - Limit of Detection
MH  - Immunoassay
MH  - Reproducibility of Results
OTO - NOTNLM
OT  - Human epidermal growth factor receptor 2
OT  - Immunosensor
OT  - Organic-inorganic heterojunction
OT  - Photoelectrochemical
OT  - Polydopamine
EDAT- 2022/10/19 06:00
MHDA- 2022/10/21 06:00
CRDT- 2022/10/18 11:14
PHST- 2022/07/14 00:00 [received]
PHST- 2022/09/10 00:00 [accepted]
PHST- 2022/10/18 11:14 [entrez]
PHST- 2022/10/19 06:00 [pubmed]
PHST- 2022/10/21 06:00 [medline]
AID - 10.1007/s00604-022-05489-x [pii]
AID - 10.1007/s00604-022-05489-x [doi]
PST - epublish
SO  - Mikrochim Acta. 2022 Oct 18;189(11):425. doi: 10.1007/s00604-022-05489-x.