PMID- 36259221
OWN - NLM
STAT- MEDLINE
DCOM- 20221020
LR  - 20230118
IS  - 1533-0338 (Electronic)
IS  - 1533-0346 (Print)
IS  - 1533-0338 (Linking)
VI  - 21
DP  - 2022 Jan-Dec
TI  - Epidemiological, Clinical, and Oncological Outcomes of non-Alcohol Drinking and 
      non-Smoking Laryngeal Squamous Cell Carcinoma Patients: A Distinct Entity.
PG  - 15330338221133690
LID - 10.1177/15330338221133690 [doi]
LID - 15330338221133690
AB  - Purpose: To explore the discrepancy in clinicopathological and prognostic 
      features between smoking and alcohol drinking (SA) and non-smoking and 
      non-alcohol drinking (NSNA) patients with laryngeal squamous cell carcinoma 
      (LSCC). Methods: This retrospective study including 1735 patients with LSCC was 
      conducted from January 2005 to December 2010, which were categorized into 4 
      groups, NSNA group, smoking only group, alcohol-drinking only group, and SA 
      group. We compared overall survival (OS) and disease-free survival (DFS) using 
      the Kaplan-Meier method and indicated clinicopathological features by Cox 
      proportional hazards regression models before and after propensity score matching 
      (PSM). Results: A total of 415 patients (23.92%) were identified as NSNA. The SA 
      group was predominantly patients </=60 years old (46.63%) while the NSNA group was 
      more older (58.07%). NSNA group was more likely to present at earlier disease 
      stage and more female. No significant difference in OS (P = .685) and DFS 
      (P = .976) was found between the 2 groups. In addition to age and recurrence and 
      metastasis being common independent prognostic factors in terms of OS in both 
      groups of patients, NSNA group also exhibited other factors, namely tumor area 
      >3.7 cm(2) and positive resection margin. For DFS, N + stage, tumor size 
      >3.7 cm(2), and positive resection margin were prognostic features specific to 
      NSNA group. Conclusion: The outcome is similar in LSCC patients with and without 
      SA. NSNA group shows a distinct profile from that found in SA group. 
      Clinicopathological features from NSNA group should be considered for LSCC 
      management.
FAU - Huang, Qiang
AU  - Huang Q
AUID- ORCID: 0000-0002-5455-9454
AD  - Department of Otorhinolaryngology, Eye & ENT Hospital, 12478Fudan University, 
      Shanghai, China.
FAU - Guo, Yang
AU  - Guo Y
AD  - Department of Otorhinolaryngology, Eye & ENT Hospital, 12478Fudan University, 
      Shanghai, China.
FAU - Shen, Yujie
AU  - Shen Y
AD  - Department of Otorhinolaryngology, Eye & ENT Hospital, 12478Fudan University, 
      Shanghai, China.
FAU - Hsueh, Chi-Yao
AU  - Hsueh CY
AD  - Department of Otorhinolaryngology, Eye & ENT Hospital, 12478Fudan University, 
      Shanghai, China.
FAU - Tao, Lei
AU  - Tao L
AD  - Department of Otorhinolaryngology, Eye & ENT Hospital, 12478Fudan University, 
      Shanghai, China.
FAU - Zhang, Ming
AU  - Zhang M
AD  - Department of Otorhinolaryngology, Eye & ENT Hospital, 12478Fudan University, 
      Shanghai, China.
FAU - Wu, Chunping
AU  - Wu C
AD  - Department of Otorhinolaryngology, Eye & ENT Hospital, 12478Fudan University, 
      Shanghai, China.
FAU - Gong, Hongli
AU  - Gong H
AD  - Department of Otorhinolaryngology, Eye & ENT Hospital, 12478Fudan University, 
      Shanghai, China.
FAU - Zhou, Liang
AU  - Zhou L
AD  - Department of Otorhinolaryngology, Eye & ENT Hospital, 12478Fudan University, 
      Shanghai, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Technol Cancer Res Treat
JT  - Technology in cancer research & treatment
JID - 101140941
SB  - IM
MH  - Humans
MH  - Female
MH  - Middle Aged
MH  - Squamous Cell Carcinoma of Head and Neck/epidemiology
MH  - *Laryngeal Neoplasms/epidemiology/therapy
MH  - *Carcinoma, Squamous Cell/epidemiology/therapy
MH  - Retrospective Studies
MH  - Margins of Excision
MH  - Prognosis
MH  - *Head and Neck Neoplasms
PMC - PMC9583220
OTO - NOTNLM
OT  - epidemiological feature
OT  - laryngeal squamous cell carcinoma
OT  - non-alcohol drinking
OT  - non-smoking
OT  - oncological outcome
COIS- The authors declared no potential conflicts of interest with respect to the 
      research, authorship, and/or publication of this article.
EDAT- 2022/10/20 06:00
MHDA- 2022/10/21 06:00
PMCR- 2022/10/19
CRDT- 2022/10/19 03:14
PHST- 2022/10/19 03:14 [entrez]
PHST- 2022/10/20 06:00 [pubmed]
PHST- 2022/10/21 06:00 [medline]
PHST- 2022/10/19 00:00 [pmc-release]
AID - 10.1177_15330338221133690 [pii]
AID - 10.1177/15330338221133690 [doi]
PST - ppublish
SO  - Technol Cancer Res Treat. 2022 Jan-Dec;21:15330338221133690. doi: 
      10.1177/15330338221133690.