PMID- 36259254
OWN - NLM
STAT- MEDLINE
DCOM- 20230214
LR  - 20230214
IS  - 1365-2362 (Electronic)
IS  - 0014-2972 (Linking)
VI  - 53
IP  - 3
DP  - 2023 Mar
TI  - Psychiatric disorders and Type 2 diabetes mellitus: A bidirectional Mendelian 
      randomization.
PG  - e13893
LID - 10.1111/eci.13893 [doi]
AB  - BACKGROUND: Extensive observational evidence put forward the association between 
      psychiatric disorders and type 2 diabetes mellitus (T2DM). However, causal 
      relationships between these two diseases required further research. Thus, we 
      evaluated the bidirection casual effect between five psychiatric disorders and 
      T2DM using two-sample mendelian randomization (MR). METHODS: By selecting single 
      nucleotide polymorphisms associated with T2DM and five psychiatric disorders 
      (attention-deficit hyperactivity disorder (ADHD), major depressive disorder 
      (MDD), schizophrenia, anxiety disorder and panic disorder), a bidirectional 
      two-sample MR was applied to evaluate causality between these diseases. The 
      inverse-variance weighted (IVW) method was used as the primary analysing approach 
      for estimating possible causal effects. MR-Egger and weighted median were also 
      conducted to verify the results. The funnel plot, Cochran's Q test and MR-Egger 
      intercept test were used for sensitivity analyses. In addition, potential 
      mediators were investigated by risk factor analyses. RESULTS: Genetic 
      susceptibilities of ADHD and MDD would increase the risk of T2DM (ADHD: 
      OR = 1.14, 95%CI 1.08-1.20; p = 5.7 x 10-6 ; MDD: OR = 1.22, 95%CI 1.09-1.36; p 
      = 0.0004 ). In addition, genetic predisposition to T2DM was also associated with 
      ADHD (OR = 1.09, 95%CI 1.04-1.14; p = 0.0004). Several risk factors of T2DM were 
      implicated in the above causal associations, including smoking, high body mass 
      index, waist-to-hip ratio and elevated serum triglycerides. CONCLUSION: Our 
      studies indicated a causal effect of ADHD and MDD on increasing the risk of T2DM, 
      which was potentially mediated by smoking and obesity-related phenotypes. 
      Meanwhile, we found a causal effect of T2DM on ADHD. Thus, prevention strategies 
      for T2DM should also include mental health and vice versa.
CI  - (c) 2022 Stichting European Society for Clinical Investigation Journal Foundation. 
      Published by John Wiley & Sons Ltd.
FAU - Tao, Haoran
AU  - Tao H
AUID- ORCID: 0000-0001-6915-3038
AD  - Department of Endocrinology, Sun Yat-Sen Memorial Hospital, Sun Yat-sen 
      University, Guangzhou, China.
AD  - Guangdong Clinical Research Center for Metabolic Diseases, Guangzhou key 
      laboratory for Metabolic Diseases, Guangzhou, China.
FAU - Fan, Shujin
AU  - Fan S
AD  - Department of Endocrinology, Sun Yat-Sen Memorial Hospital, Sun Yat-sen 
      University, Guangzhou, China.
AD  - Guangdong Clinical Research Center for Metabolic Diseases, Guangzhou key 
      laboratory for Metabolic Diseases, Guangzhou, China.
FAU - Zhu, Tianxin
AU  - Zhu T
AD  - Department of Endocrinology, Sun Yat-Sen Memorial Hospital, Sun Yat-sen 
      University, Guangzhou, China.
AD  - Guangdong Clinical Research Center for Metabolic Diseases, Guangzhou key 
      laboratory for Metabolic Diseases, Guangzhou, China.
FAU - You, Lili
AU  - You L
AUID- ORCID: 0000-0001-6815-5939
AD  - Department of Endocrinology, Sun Yat-Sen Memorial Hospital, Sun Yat-sen 
      University, Guangzhou, China.
AD  - Guangdong Clinical Research Center for Metabolic Diseases, Guangzhou key 
      laboratory for Metabolic Diseases, Guangzhou, China.
FAU - Zheng, Dinghao
AU  - Zheng D
AD  - Department of Endocrinology, Sun Yat-Sen Memorial Hospital, Sun Yat-sen 
      University, Guangzhou, China.
AD  - Guangdong Clinical Research Center for Metabolic Diseases, Guangzhou key 
      laboratory for Metabolic Diseases, Guangzhou, China.
FAU - Yan, Li
AU  - Yan L
AD  - Department of Endocrinology, Sun Yat-Sen Memorial Hospital, Sun Yat-sen 
      University, Guangzhou, China.
AD  - Guangdong Clinical Research Center for Metabolic Diseases, Guangzhou key 
      laboratory for Metabolic Diseases, Guangzhou, China.
FAU - Ren, Meng
AU  - Ren M
AUID- ORCID: 0000-0001-9935-1449
AD  - Department of Endocrinology, Sun Yat-Sen Memorial Hospital, Sun Yat-sen 
      University, Guangzhou, China.
AD  - Guangdong Clinical Research Center for Metabolic Diseases, Guangzhou key 
      laboratory for Metabolic Diseases, Guangzhou, China.
LA  - eng
GR  - 2020B1111170009/Guangdong Clinical Research Center for Metabolic Diseases/
GR  - 202102100004/Guangzhou key laboratory for Metabolic Diseases/
GR  - U20A20352/National Natural Science Foundation of China-Guangdong Joint Fund/
PT  - Journal Article
DEP - 20221108
PL  - England
TA  - Eur J Clin Invest
JT  - European journal of clinical investigation
JID - 0245331
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/epidemiology/genetics/complications
MH  - *Depressive Disorder, Major/epidemiology/genetics/complications
MH  - Mendelian Randomization Analysis/methods
MH  - Risk Factors
MH  - *Attention Deficit Disorder with 
      Hyperactivity/epidemiology/genetics/complications
MH  - Polymorphism, Single Nucleotide
OTO - NOTNLM
OT  - attention-deficit hyperactivity disorder
OT  - diabetes
OT  - mendelian randomization
OT  - psychiatric disorders
EDAT- 2022/10/20 06:00
MHDA- 2023/02/15 06:00
CRDT- 2022/10/19 04:03
PHST- 2022/10/11 00:00 [revised]
PHST- 2022/09/10 00:00 [received]
PHST- 2022/10/17 00:00 [accepted]
PHST- 2022/10/20 06:00 [pubmed]
PHST- 2023/02/15 06:00 [medline]
PHST- 2022/10/19 04:03 [entrez]
AID - 10.1111/eci.13893 [doi]
PST - ppublish
SO  - Eur J Clin Invest. 2023 Mar;53(3):e13893. doi: 10.1111/eci.13893. Epub 2022 Nov 
      8.