PMID- 36260278
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230404
IS  - 2193-8237 (Print)
IS  - 2193-651X (Electronic)
VI  - 12
IP  - 1
DP  - 2023 Feb
TI  - Efficacy and Safety of Methylprednisolone for Lung Surgery: a Systematic Review 
      and Meta-analysis of Randomized Controlled Trials.
PG  - 165-186
LID - 10.1007/s40122-022-00443-4 [doi]
AB  - INTRODUCTION: The administration of methylprednisolone (MP) is a component of 
      perioperative multimodal analgesia that mitigates the potentially deleterious 
      effects of postoperative pain and opioid consumption. However, a systematic 
      evaluation of the efficacy and safety of MP is lacking. The present systematic 
      review and meta-analysis was performed to quantify the potential clinical 
      benefits and risks of perioperative MP in lung surgery. METHODS: We searched 
      seven electronic databases for randomized controlled trials (RCTs) comparing MP 
      with placebo. Coprimary outcomes were rest pain scores, dynamic pain scores, and 
      cumulative morphine equivalent consumption within 24 h postoperatively. RESULTS: 
      A total of 11 trials including 643 participants were selected for our 
      meta-analysis. The results demonstrated that the MP group had a significant 
      difference in coprimary outcomes (rest pain scores, dynamic pain scores, and 
      cumulative morphine equivalent consumption) compared with the placebo group; 
      nevertheless, the improvement was not clinically meaningful based on minimum 
      clinically important differences (MCID). Notably, MP administration reduced serum 
      levels of interleukin (IL)-6 at 6 h (weighted mean difference -20.49 pg/mL; 95% 
      CI -29.94 to -11.04), and decreased the incidence rate of acute lung injury (rate 
      ratio 0.18; 95% CI 0.03-0.98) and cognitive dysfunction (rate ratio 0.43; 95% CI 
      0.21-0.88) compared with the placebo group. CONCLUSIONS: Our findings suggest 
      that the administration of MP contributed to an insignificant relief in acute 
      postoperative pain for lung surgery in a clinical setting. Future studies should 
      focus on exploring the role of MP in reducing pulmonary and surgical-related 
      complications after lung surgery. CLINICAL TRIAL NUMBER: PROSPERO registration 
      number CRD42022314224.
CI  - (c) 2022. The Author(s).
FAU - Fu, Xi
AU  - Fu X
AD  - Hospital of Chengdu University of Traditional Chinese Medicine, No. 39 
      Shi-er-qiao Road, Chengdu, 610072, Sichuan, China.
FAU - Ye, Xin
AU  - Ye X
AD  - Hospital of Chengdu University of Traditional Chinese Medicine, No. 39 
      Shi-er-qiao Road, Chengdu, 610072, Sichuan, China. klpkyx@sina.cn.
FAU - An, Li-Na
AU  - An LN
AD  - Outpatient Department of Western Theater, Command General Hospital, Chengdu, 
      Sichuan, China.
FAU - Jiang, Hua
AU  - Jiang H
AD  - Hospital of Chengdu University of Traditional Chinese Medicine, No. 39 
      Shi-er-qiao Road, Chengdu, 610072, Sichuan, China.
FAU - Huang, Wen-Bo
AU  - Huang WB
AD  - Hospital of Chengdu University of Traditional Chinese Medicine, No. 39 
      Shi-er-qiao Road, Chengdu, 610072, Sichuan, China.
FAU - Huang, Ya
AU  - Huang Y
AD  - Hospital of Chengdu University of Traditional Chinese Medicine, No. 39 
      Shi-er-qiao Road, Chengdu, 610072, Sichuan, China.
FAU - Dong, Jing
AU  - Dong J
AD  - Hospital of Chengdu University of Traditional Chinese Medicine, No. 39 
      Shi-er-qiao Road, Chengdu, 610072, Sichuan, China. jean7dj960@gmail.com.
FAU - Ren, Yi-Feng
AU  - Ren YF
AUID- ORCID: 0000-0003-2976-4250
AD  - Hospital of Chengdu University of Traditional Chinese Medicine, No. 39 
      Shi-er-qiao Road, Chengdu, 610072, Sichuan, China. ryftcm.dr@yahoo.com.
LA  - eng
PT  - Journal Article
DEP - 20221019
PL  - New Zealand
TA  - Pain Ther
JT  - Pain and therapy
JID - 101634491
PMC - PMC9845491
OTO - NOTNLM
OT  - Lung surgery
OT  - Meta-analysis
OT  - Methylprednisolone (MP)
OT  - Perioperative multimodal analgesia
OT  - Systematic review
EDAT- 2022/10/20 06:00
MHDA- 2022/10/20 06:01
PMCR- 2022/10/19
CRDT- 2022/10/19 11:20
PHST- 2022/07/29 00:00 [received]
PHST- 2022/09/22 00:00 [accepted]
PHST- 2022/10/20 06:00 [pubmed]
PHST- 2022/10/20 06:01 [medline]
PHST- 2022/10/19 11:20 [entrez]
PHST- 2022/10/19 00:00 [pmc-release]
AID - 10.1007/s40122-022-00443-4 [pii]
AID - 443 [pii]
AID - 10.1007/s40122-022-00443-4 [doi]
PST - ppublish
SO  - Pain Ther. 2023 Feb;12(1):165-186. doi: 10.1007/s40122-022-00443-4. Epub 2022 Oct 
      19.