PMID- 36260563
OWN - NLM
STAT- MEDLINE
DCOM- 20221129
LR  - 20230125
IS  - 1936-086X (Electronic)
IS  - 1936-0851 (Linking)
VI  - 16
IP  - 11
DP  - 2022 Nov 22
TI  - Metal-Organic Framework-Derived Carbon as a Photoacoustic Modulator of 
      Alzheimer's beta-Amyloid Aggregate Structure.
PG  - 18515-18525
LID - 10.1021/acsnano.2c06759 [doi]
AB  - Photoacoustic materials emit acoustic waves into the surrounding by absorbing 
      photon energy. In an aqueous environment, light-induced acoustic waves form 
      cavitation bubbles by altering the localized pressure to trigger the phase 
      transition of liquid water into vapor. In this study, we report photoacoustic 
      dissociation of beta-amyloid (Abeta) aggregates, a hallmark of Alzheimer's disease, 
      by metal-organic framework-derived carbon (MOFC). MOFC exhibits a near-infrared 
      (NIR) light-responsive photoacoustic characteristic that possesses defect-rich 
      and entangled graphitic layers that generate intense cavitation bubbles by 
      absorbing tissue-penetrable NIR light. According to our video analysis, the 
      photoacoustic cavitation by MOFC occurs within milliseconds in the water, which 
      was controllable by NIR light dose. The photoacoustic cavitation successfully 
      transforms robust, beta-sheet-dominant neurotoxic Abeta aggregates into nontoxic debris 
      by changing the asymmetric distribution of water molecules around the Abeta's amino 
      acid residues. This work unveils the therapeutic potential of NIR-triggered 
      photoacoustic cavitation as a modulator of the Abeta aggregate structure.
FAU - Jang, Jinhyeong
AU  - Jang J
AD  - Department of Materials Science and Engineering, Korea Advanced Institute of 
      Science and Technology (KAIST), 335 Science Road, Daejeon 34141, Republic of 
      Korea.
FAU - Jo, Yonghan
AU  - Jo Y
AD  - Department of Materials Science and Engineering, Korea Advanced Institute of 
      Science and Technology (KAIST), 335 Science Road, Daejeon 34141, Republic of 
      Korea.
FAU - Park, Chan Beum
AU  - Park CB
AUID- ORCID: 0000-0002-0767-8629
AD  - Department of Materials Science and Engineering, Korea Advanced Institute of 
      Science and Technology (KAIST), 335 Science Road, Daejeon 34141, Republic of 
      Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20221019
PL  - United States
TA  - ACS Nano
JT  - ACS nano
JID - 101313589
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Metal-Organic Frameworks)
RN  - 7440-44-0 (Carbon)
RN  - 059QF0KO0R (Water)
SB  - IM
MH  - Humans
MH  - Amyloid beta-Peptides/chemistry
MH  - *Metal-Organic Frameworks/pharmacology
MH  - *Alzheimer Disease/diagnostic imaging
MH  - Carbon
MH  - Water
MH  - *Photoacoustic Techniques
OTO - NOTNLM
OT  - amyloid
OT  - carbon nanoparticles
OT  - metal-organic framework
OT  - near-infrared light
OT  - photoacoustic
EDAT- 2022/10/20 06:00
MHDA- 2022/11/30 06:00
CRDT- 2022/10/19 13:33
PHST- 2022/10/20 06:00 [pubmed]
PHST- 2022/11/30 06:00 [medline]
PHST- 2022/10/19 13:33 [entrez]
AID - 10.1021/acsnano.2c06759 [doi]
PST - ppublish
SO  - ACS Nano. 2022 Nov 22;16(11):18515-18525. doi: 10.1021/acsnano.2c06759. Epub 2022 
      Oct 19.