PMID- 36261703
OWN - NLM
STAT- MEDLINE
DCOM- 20230629
LR  - 20230629
IS  - 1937-5395 (Electronic)
IS  - 1937-5387 (Linking)
VI  - 16
IP  - 3
DP  - 2023 Jun
TI  - Subclinical Leaflet Thrombosis in Supra-annular Transcatheter Aortic Valves: the 
      Role of Leaflet Design.
PG  - 674-681
LID - 10.1007/s12265-022-10333-x [doi]
AB  - Subclinical leaflet thrombosis has been increasingly observed in patients 
      undergoing transcatheter aortic valve replacement. Intra-annular transcatheter 
      aortic valves (TAVs) have a larger neo-sinus volume than supra-annular devices 
      and are potentially at a higher risk of hypoattenuated leaflet thickening (HALT). 
      However, clinical data from randomized clinical trials have shown that 
      approximately one-third of patients undergoing TAVR with intra- or supra-annular 
      devices develop HALT in 1 year. The findings point to the potential role of 
      leaflet design in developing HALT. The study aimed to systematically investigate 
      leaflet kinematics of a supra-annular TAV, Medtronic CoreValve, and determine 
      regions of blood stasis. Fluid-solid interaction simulations demonstrated the 
      limited movement of CoreValve leaflets in the lower belly region that created 
      regions of blood stasis on the surface of the leaflets. The findings provide 
      insights into potential improvements in leaflet design in the next generation of 
      TAVs to reduce the risk of HALT and leaflet immobility.
CI  - (c) 2022. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Qiu, Dong
AU  - Qiu D
AD  - Department of Mechanical and Materials Engineering, University of Denver, 2155 E. 
      Wesley Ave, Room 439, Denver, CO, 80208, USA.
FAU - Azadani, Ali N
AU  - Azadani AN
AD  - Department of Mechanical and Materials Engineering, University of Denver, 2155 E. 
      Wesley Ave, Room 439, Denver, CO, 80208, USA. ali.azadani@du.edu.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20221019
PL  - United States
TA  - J Cardiovasc Transl Res
JT  - Journal of cardiovascular translational research
JID - 101468585
SB  - IM
MH  - Humans
MH  - Aortic Valve/diagnostic imaging/surgery
MH  - *Heart Valve Prosthesis
MH  - *Transcatheter Aortic Valve Replacement/adverse effects
MH  - *Thrombosis/diagnostic imaging/etiology/surgery
MH  - *Aortic Valve Stenosis/surgery
MH  - Prosthesis Design
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Flow stasis
OT  - Hypoattenuated leaflet thickening
OT  - Leaflet design
OT  - Neo-sinus
OT  - Subclinical leaflet thrombosis
OT  - Transcatheter aortic valve replacement
EDAT- 2022/10/20 06:00
MHDA- 2023/06/29 06:43
CRDT- 2022/10/19 23:41
PHST- 2022/05/09 00:00 [received]
PHST- 2022/10/11 00:00 [accepted]
PHST- 2023/06/29 06:43 [medline]
PHST- 2022/10/20 06:00 [pubmed]
PHST- 2022/10/19 23:41 [entrez]
AID - 10.1007/s12265-022-10333-x [pii]
AID - 10.1007/s12265-022-10333-x [doi]
PST - ppublish
SO  - J Cardiovasc Transl Res. 2023 Jun;16(3):674-681. doi: 10.1007/s12265-022-10333-x. 
      Epub 2022 Oct 19.