PMID- 36262850
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221021
IS  - 2222-3959 (Print)
IS  - 2227-4898 (Electronic)
IS  - 2222-3959 (Linking)
VI  - 15
IP  - 10
DP  - 2022
TI  - Visual field defects and retinal nerve fiber layer damage in buried optic disc 
      drusen: a new insight.
PG  - 1641-1649
LID - 10.18240/ijo.2022.10.12 [doi]
AB  - AIM: To assess the association between buried optic disc drusen (BODD) location 
      using spectral-domain optical coherence tomography (SD-OCT) and the location of 
      associated visual field defects (VFD) using the Garway-Heath mapping. METHODS: 
      This monocentric retrospective cross-sectional study was led at the authors' 
      institution. Adult patients diagnosed with BODD who had complete records with a 
      reliable Humphrey((R)) 24-2 visual field, macular, and papillary OCT were enrolled. 
      Fisher's exact test was used to measure the association between BODD location and 
      VFD distribution according to Garway-Heath's mapping. RESULTS: Totally 20 eyes of 
      15 patients were included (60% females). The median age (interquartile range) was 
      63 (43)y and the median best corrected visual acuity (BCVA) was -0.08 (0.08) log 
      MAR. BODD were mostly located in zones A, E, and F. The minimal rim width (MRW) 
      was globally preserved. The retinal nerve fiber layer (RNFL) was predominantly 
      altered in zones D, E, and F. There was a significant correlation between BODD 
      location and that of RNFL alterations in zones D (P=0.03) and E (P=0.025); 
      Moreover, the presence of BODD in the E zone was significantly related to damaged 
      RNFL in the neighbouring sectors D and F (P=0.012; P=0.02 respectively). 
      Sixty-three percent (12/19) of visual fields were abnormal and there was a 
      significant match (Phi=0.7, P=0.009) between drusen location and VFD only in zone 
      D. CONCLUSION: BODD do not only affect young patients and can be more harmful 
      than usually expected, as we found VFD in 63% of cases. There is a correspondence 
      between BODD location, RNFL damage, and VFD distributions. The presence of BODD 
      induces the overestimation of MRW, thereby disrupting its sensitivity as an early 
      indicator of ganglion fibers damage.
CI  - International Journal of Ophthalmology Press.
FAU - Nana Wandji, Brenda
AU  - Nana Wandji B
AD  - Faculty of Medicine, Universite Libre de Bruxelles, Brussels 1070, Belgium.
FAU - Dugauquier, Artemise
AU  - Dugauquier A
AD  - Department of Ophthalmology, Erasme Hospital, Brussels 1070, Belgium.
FAU - Ehongo, Adele
AU  - Ehongo A
AD  - Department of Ophthalmology, Erasme Hospital, Brussels 1070, Belgium.
LA  - eng
PT  - Journal Article
DEP - 20221018
PL  - China
TA  - Int J Ophthalmol
JT  - International journal of ophthalmology
JID - 101553860
PMC - PMC9522567
OTO - NOTNLM
OT  - Garway-Heath mapping
OT  - buried optic disc drusen
OT  - retinal nerve fiber layer
OT  - spectral-domain optical coherence tomography
OT  - visual field
EDAT- 2022/10/21 06:00
MHDA- 2022/10/21 06:01
PMCR- 2022/10/18
CRDT- 2022/10/20 02:46
PHST- 2022/04/11 00:00 [received]
PHST- 2022/07/05 00:00 [accepted]
PHST- 2022/10/20 02:46 [entrez]
PHST- 2022/10/21 06:00 [pubmed]
PHST- 2022/10/21 06:01 [medline]
PHST- 2022/10/18 00:00 [pmc-release]
AID - ijo-15-10-1641 [pii]
AID - 10.18240/ijo.2022.10.12 [doi]
PST - epublish
SO  - Int J Ophthalmol. 2022 Oct 18;15(10):1641-1649. doi: 10.18240/ijo.2022.10.12. 
      eCollection 2022.