PMID- 36262975 OWN - NLM STAT- MEDLINE DCOM- 20221021 LR - 20221021 IS - 2314-6141 (Electronic) IS - 2314-6133 (Print) VI - 2022 DP - 2022 TI - Emerging Role of Dendritic Cell Intervention in the Treatment of Inflammatory Bowel Disease. PG - 7025634 LID - 10.1155/2022/7025634 [doi] LID - 7025634 AB - Dendritic cells (DCs) are the most important antigen-presenting cells and are pivotal in initiating effective adaptive immune responses to induce immune tolerance and maintain immune homeostasis. Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is chronic, intestinal inflammatory and autoimmune disorder. DCs participate in IBD pathogenesis. This review is aimed at briefly discussing the role of DCs in IBD and the relationship between them and highlighting the prominent role of these cells in the treatment of these disorders. CI - Copyright (c) 2022 Donglei Sun et al. FAU - Sun, Donglei AU - Sun D AUID- ORCID: 0000-0002-7930-7544 AD - Department of Gastroenterology, The Second Hospital of Hebei Medical University, Hebei Key Laboratory of Gastroenterology, Hebei Institute of Gastroenterology, Shijiazhuang, China. FAU - Li, Chenyang AU - Li C AUID- ORCID: 0000-0002-7498-8408 AD - Department of Gastroenterology, The Second Hospital of Hebei Medical University, Hebei Key Laboratory of Gastroenterology, Hebei Institute of Gastroenterology, Shijiazhuang, China. FAU - Chen, Shuang AU - Chen S AD - Department of Pediatrics and Department of Biomedical Science, Cedars Sinai Medical Center, Los Angeles, USA. FAU - Zhang, Xiaolan AU - Zhang X AUID- ORCID: 0000-0002-7047-3634 AD - Department of Gastroenterology, The Second Hospital of Hebei Medical University, Hebei Key Laboratory of Gastroenterology, Hebei Institute of Gastroenterology, Shijiazhuang, China. LA - eng PT - Journal Article PT - Review DEP - 20221010 PL - United States TA - Biomed Res Int JT - BioMed research international JID - 101600173 SB - IM MH - Humans MH - *Inflammatory Bowel Diseases/pathology MH - *Crohn Disease/pathology MH - *Colitis, Ulcerative/pathology MH - Dendritic Cells PMC - PMC9576373 COIS- All authors declare no conflicts of interest in this paper. EDAT- 2022/10/21 06:00 MHDA- 2022/10/22 06:00 PMCR- 2022/10/10 CRDT- 2022/10/20 02:50 PHST- 2022/07/21 00:00 [received] PHST- 2022/09/27 00:00 [accepted] PHST- 2022/10/20 02:50 [entrez] PHST- 2022/10/21 06:00 [pubmed] PHST- 2022/10/22 06:00 [medline] PHST- 2022/10/10 00:00 [pmc-release] AID - 10.1155/2022/7025634 [doi] PST - epublish SO - Biomed Res Int. 2022 Oct 10;2022:7025634. doi: 10.1155/2022/7025634. eCollection 2022.