PMID- 36264034
OWN - NLM
STAT- MEDLINE
DCOM- 20230301
LR  - 20230303
IS  - 1308-5735 (Electronic)
IS  - 1308-5727 (Print)
VI  - 15
IP  - 1
DP  - 2023 Feb 27
TI  - Factors Associated with Low Bone Mineral Density at the Time of Diagnosis in 
      Children with Celiac Disease.
PG  - 62-68
LID - 10.4274/jcrpe.galenos.2022.2022-5-18 [doi]
AB  - OBJECTIVE: It has been reported that bone mineral density (BMD) is decreased in 
      children with Celiac disease (CD) compared to their healthy peers. The aim of 
      this study was to reveal possible risk factors for low BMD in Turkish children 
      newly diagnosed with CD. METHODS: Eighty-six patients (2-18 years old) with CD 
      were included in this retrospective study. The relationship between their lumbar 
      BMD z-scores calculated according to their chronological age (CA) and height age 
      (HA) and their clinical, laboratory [biochemical parameters, tissue 
      transglutaminase antibody-IgA (TTGA) levels, human leukocyte antigen (HLA) types] 
      and histopathological parameters were evaluated. RESULTS: The mean age of the 
      patients at diagnosis was 8.06+/-4.08 years. The BMD z-score CA was </=-2 standard 
      deviation (SD) in 26.7% of the patients. The BMD z-score HA was </=-2 SD in 12.8% 
      of the patients. The BMD z-score HA only correlated with their age at diagnosis 
      of CD (r(s) value 0.269). However, there was no statistically difference between 
      the BMD z-score HA >-2 SD and </=-2 SD subgroups regarding their clinical, 
      laboratory and histopathological parameters. CONCLUSION: Low BMD is common in 
      children with newly diagnosed CD. Age at diagnosis, gender, body size, Celiac 
      symptoms, biochemical parameters, TTGA level, HLA type, and histopathological 
      stage had no predictive values in terms of low BMD in this patient group.
CI  - (c)Copyright 2023 by Turkish Society for Pediatric Endocrinology and Diabetes | The 
      Journal of Clinical Research in Pediatric Endocrinology published by Galenos 
      Publishing House.
FAU - Camtosun, Emine
AU  - Camtosun E
AUID- ORCID: 0000-0002-8144-4409
AD  - Inonu University Faculty of Medicine, Department of Pediatric Endocrinology, 
      Malatya, Turkey
FAU - Varol, Fatma Ilknur
AU  - Varol FI
AUID- ORCID: 0000-0001-5212-218X
AD  - Inonu University Faculty of Medicine, Department of Pediatric Gastroenterology, 
      Hepatology and Nutrition, Malatya, Turkey
FAU - Gungor, Sukru
AU  - Gungor S
AUID- ORCID: 0000-0002-0433-5970
AD  - Inonu University Faculty of Medicine, Department of Pediatric Gastroenterology, 
      Hepatology and Nutrition, Malatya, Turkey
FAU - Selimoglu, Mukadder Ayse
AU  - Selimoglu MA
AUID- ORCID: 0000-0001-8533-8446
AD  - Inonu University Faculty of Medicine, Department of Pediatric Gastroenterology, 
      Hepatology and Nutrition, Malatya, Turkey
LA  - eng
PT  - Journal Article
DEP - 20221020
PL  - Turkey
TA  - J Clin Res Pediatr Endocrinol
JT  - Journal of clinical research in pediatric endocrinology
JID - 101519456
SB  - IM
MH  - Humans
MH  - Child
MH  - Child, Preschool
MH  - Adolescent
MH  - *Celiac Disease/diagnosis
MH  - Retrospective Studies
MH  - Absorptiometry, Photon/adverse effects
MH  - *Bone Diseases, Metabolic
MH  - Bone Density
PMC - PMC9976161
OTO - NOTNLM
OT  - Low bone mineral density
OT  - children
OT  - risk factors
OT  - Celiac disease
EDAT- 2022/10/21 06:00
MHDA- 2023/03/03 06:00
PMCR- 2023/03/01
CRDT- 2022/10/20 08:28
PHST- 2022/10/20 08:28 [entrez]
PHST- 2022/10/21 06:00 [pubmed]
PHST- 2023/03/03 06:00 [medline]
PHST- 2023/03/01 00:00 [pmc-release]
AID - 58726 [pii]
AID - 10.4274/jcrpe.galenos.2022.2022-5-18 [doi]
PST - ppublish
SO  - J Clin Res Pediatr Endocrinol. 2023 Feb 27;15(1):62-68. doi: 
      10.4274/jcrpe.galenos.2022.2022-5-18. Epub 2022 Oct 20.