PMID- 36264685
OWN - NLM
STAT- MEDLINE
DCOM- 20230605
LR  - 20230824
IS  - 1536-3732 (Electronic)
IS  - 1049-2275 (Linking)
VI  - 34
IP  - 4
DP  - 2023 Jun 1
TI  - Genetic Polymorphisms of Estrogen Receptors alpha and beta are Associated with 
      Craniofacial Measurements in Patients With Dentofacial Deformity.
PG  - 1262-1266
LID - 10.1097/SCS.0000000000009064 [doi]
AB  - Dentofacial deformities are characterized by abnormalities in craniofacial 
      development that affects the individual's skeletal and occlusion, often causing 
      functional and esthetic problems. In literature, there is an involvement of 
      polymorphisms in estrogen receptor 1 (ESR1) and estrogen receptor 2 (ESR2) genes 
      in craniofacial measurements. The aim of this study was to evaluate a possible 
      association between polymorphisms in ESR1 (rs2234693 and rs9340799) and ESR2 
      (rs1256049 and rs4986938) genes with cephalometric measurements in individuals 
      with dentofacial deformities. This cross-sectional study was performed with 158 
      individuals in the preoperative period of orthognathic surgery. The cephalometric 
      measurements obtained through lateral cephalogram using Dolphin Imaging software. 
      For genetic analysis, the DNA extracted from epithelial cells of the oral mucosa 
      and were genotyped using the real-time polymerase chain reaction. The data found 
      submitted to statistical analysis, through the Kolmogorov-Smirnov, Mann-Whitney, 
      and Kruskal-Wallis tests, using the IBM SPSS software version 24.0. Considered a 
      significance level of 0.05. We found association between polymorphisms and 
      cephalometric measurements just in the female sex. The polymorphisms 
      ESR1/rs9340799 ( P= 0.003), ESR1/rs2234693 ( P= 0.026), and ESR2/rs1256049 ( P= 
      0.046) were associated with the upper gonial angle (Ar-Go-N). The polymorphism 
      ESR2/rs1256049 was also associated with the facial axis-rickets (NBa-PtGn) ( P= 
      0.004), anterior cranial base (SN) ( P= 0.036), and Y-axis (SGn-SN) ( P= 0.031).
CI  - Copyright (c) 2022 by Mutaz B. Habal, MD.
FAU - Lago, Camila
AU  - Lago C
AD  - School of Health Sciences, Positivo University, Campo Comprido.
FAU - Okida, Debora Kimie Padilha
AU  - Okida DKP
AD  - School of Health Sciences, Positivo University, Campo Comprido.
FAU - Cordeiro, Joao Francisco Barbosa
AU  - Cordeiro JFB
AD  - School of Life and Health Sciences, Department of Dentistry, West University of 
      Santa Catarina, Joacaba, SC, Brazil.
FAU - Gerber, Jennifer Tsi
AU  - Gerber JT
AD  - School of Health Sciences, Positivo University, Campo Comprido.
FAU - Kuchler, Erika Calvano
AU  - Kuchler EC
AD  - Department of Dentistry, Regensburg University, Ratisbona, Germany.
FAU - Rebellato, Nelson Luis Barbosa
AU  - Rebellato NLB
AD  - Department of Stomatology, School of Dentistry, Federal University of Parana, 
      Curitiba, PR.
FAU - Moro, Alexandre
AU  - Moro A
AD  - School of Health Sciences, Positivo University, Campo Comprido.
FAU - Scariot, Rafaela
AU  - Scariot R
AD  - Department of Stomatology, School of Dentistry, Federal University of Parana, 
      Curitiba, PR.
FAU - Sebastiani, Aline Monise
AU  - Sebastiani AM
AD  - Department of Stomatology, School of Dentistry, Federal University of Parana, 
      Curitiba, PR.
LA  - eng
PT  - Journal Article
DEP - 20221020
PL  - United States
TA  - J Craniofac Surg
JT  - The Journal of craniofacial surgery
JID - 9010410
RN  - 0 (Estrogen Receptor alpha)
RN  - 0 (Estrogen Receptor beta)
MH  - Female
MH  - Humans
MH  - *Estrogen Receptor alpha/genetics
MH  - *Dentofacial Deformities
MH  - Polymorphism, Single Nucleotide
MH  - Cross-Sectional Studies
MH  - Esthetics, Dental
MH  - Estrogen Receptor beta/genetics
MH  - Genetic Predisposition to Disease
COIS- The authors report no conflicts of interest.
EDAT- 2022/10/21 06:00
MHDA- 2023/06/05 06:42
CRDT- 2022/10/20 13:03
PHST- 2022/03/11 00:00 [received]
PHST- 2022/08/08 00:00 [accepted]
PHST- 2023/06/05 06:42 [medline]
PHST- 2022/10/21 06:00 [pubmed]
PHST- 2022/10/20 13:03 [entrez]
AID - 00001665-202306000-00026 [pii]
AID - 10.1097/SCS.0000000000009064 [doi]
PST - ppublish
SO  - J Craniofac Surg. 2023 Jun 1;34(4):1262-1266. doi: 10.1097/SCS.0000000000009064. 
      Epub 2022 Oct 20.