PMID- 36265728 OWN - NLM STAT- MEDLINE DCOM- 20221207 LR - 20221207 IS - 1873-6424 (Electronic) IS - 0269-7491 (Linking) VI - 316 IP - Pt 1 DP - 2023 Jan 1 TI - Association between organophosphorus pesticide exposure and depression risk in adults: A cross-sectional study with NHANES data. PG - 120445 LID - S0269-7491(22)01659-1 [pii] LID - 10.1016/j.envpol.2022.120445 [doi] AB - Organophosphorus pesticides (OPPs) are widely used pesticides, and previous studies showed that OPPs can increase the risk of central nervous system disorders (e.g., Parkinson's and Alzheimer's disease). However, few studies have comprehensively explored their association with depression in general adults. We analyzed data from 5206 participants aged 20 years or more based on four National Health and Nutrition Examination Survey (NHANES) cycles. OPPs exposure was estimated using measures of urinary concentrations for six OPPs metabolites. Survey-weighted generalized linear regression model (SWGLM) was used to explore the association of OPPs metabolites with depression. Subgroup analyses were performed by age (<==60 years and >60 years) and gender. The weighted quantile sum (WQS) regression model was used to explore the overall association of six OPPs metabolites with depression. In addition, The Bayesian kernel machine regression (BKMR) model was applied to investigate the interaction and joint effects of multiple OPPs metabolites with depression. The SWGLM showed that dimethyl phosphate (DMP) and dimethyl thiophosphate (DMTP), whether taken as continuous or quartile variables, had a positive correlation with depression. Diethyl phosphate (DEP) and dimethyl dithiophosphate (DMDTP) in the highest quartile were positively associated with depression compared to the lowest quartile. In subgroup analysis, we found that the effects of the above chemicals on depression existed in the male and young middle-aged population, while DMP was present in the female. There was a significant combined overall effect of six OPPs metabolites with depression [OR = 1.232, 95%CI: (1.011, 1.504)] in WQS. Furthermore, the BKMR model also showed a positive trend in the overall effect of six OPPs metabolites with depression. In conclusion, our results suggest that exposure to OPPs may increase the risk of depression in US adults. Men and young and middle-aged populations are more vulnerable to OPPs and the mixture of OPPs metabolites may induce depression. CI - Copyright (c) 2022 Elsevier Ltd. All rights reserved. FAU - Wu, Yudong AU - Wu Y AD - Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, Anhui, 230032, China; Anhui Province Key Laboratory of Major Autoimmune Diseases, Hefei, Anhui, 230032, China. FAU - Song, Jian AU - Song J AD - Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, Anhui, 230032, China; Anhui Province Key Laboratory of Major Autoimmune Diseases, Hefei, Anhui, 230032, China. FAU - Zhang, Qin AU - Zhang Q AD - Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, Anhui, 230032, China; Anhui Province Key Laboratory of Major Autoimmune Diseases, Hefei, Anhui, 230032, China. FAU - Yan, Shuangshuang AU - Yan S AD - Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, Anhui, 230032, China; Anhui Province Key Laboratory of Major Autoimmune Diseases, Hefei, Anhui, 230032, China. FAU - Sun, Xiaoni AU - Sun X AD - Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, Anhui, 230032, China; Anhui Province Key Laboratory of Major Autoimmune Diseases, Hefei, Anhui, 230032, China. FAU - Yi, Weizhuo AU - Yi W AD - Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, Anhui, 230032, China; Anhui Province Key Laboratory of Major Autoimmune Diseases, Hefei, Anhui, 230032, China. FAU - Pan, Rubing AU - Pan R AD - Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, Anhui, 230032, China; Anhui Province Key Laboratory of Major Autoimmune Diseases, Hefei, Anhui, 230032, China. FAU - Cheng, Jian AU - Cheng J AD - Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, Anhui, 230032, China; Anhui Province Key Laboratory of Major Autoimmune Diseases, Hefei, Anhui, 230032, China. FAU - Xu, Zhiwei AU - Xu Z AD - School of Public Health, Faculty of Medicine, University of Queensland, 288 Herston Road, Herston, QLD, 4006, Australia. FAU - Su, Hong AU - Su H AD - Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, Anhui, 230032, China; Anhui Province Key Laboratory of Major Autoimmune Diseases, Hefei, Anhui, 230032, China. Electronic address: suhong5151@sina.com. LA - eng PT - Journal Article DEP - 20221018 PL - England TA - Environ Pollut JT - Environmental pollution (Barking, Essex : 1987) JID - 8804476 RN - 0 (Pesticides) RN - 0 (Organophosphorus Compounds) SB - IM MH - Adult MH - Middle Aged MH - Male MH - Humans MH - Female MH - *Pesticides/analysis MH - Organophosphorus Compounds/toxicity MH - Nutrition Surveys MH - Cross-Sectional Studies MH - Environmental Exposure MH - Bayes Theorem MH - Depression/chemically induced/epidemiology OTO - NOTNLM OT - Depression OT - Environmental exposure OT - General population OT - Joint effect OT - Organophosphorus pesticide COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2022/10/21 06:00 MHDA- 2023/02/25 06:00 CRDT- 2022/10/20 19:35 PHST- 2022/05/12 00:00 [received] PHST- 2022/10/12 00:00 [revised] PHST- 2022/10/13 00:00 [accepted] PHST- 2022/10/21 06:00 [pubmed] PHST- 2023/02/25 06:00 [medline] PHST- 2022/10/20 19:35 [entrez] AID - S0269-7491(22)01659-1 [pii] AID - 10.1016/j.envpol.2022.120445 [doi] PST - ppublish SO - Environ Pollut. 2023 Jan 1;316(Pt 1):120445. doi: 10.1016/j.envpol.2022.120445. Epub 2022 Oct 18.