PMID- 36266935
OWN - NLM
STAT- MEDLINE
DCOM- 20221024
LR  - 20221104
IS  - 1643-3750 (Electronic)
IS  - 1234-1010 (Print)
IS  - 1234-1010 (Linking)
VI  - 28
DP  - 2022 Oct 21
TI  - Distribution and Determinants of Plasma Homocysteine Levels in a Preconception 
      Population: A Retrospective Single-Center Study.
PG  - e937987
LID - 10.12659/MSM.937987 [doi]
AB  - BACKGROUND Raised plasma homocysteine (Hcy) levels have been associated with 
      various diseases and pregnancy complications. Preconception is the primary 
      prevention period to prevent birth defects. This retrospective study aimed to 
      investigate the distribution of plasma Hcy levels among men and women at 
      preconception and further evaluate the factors influencing plasma Hcy levels in a 
      Southern China population. MATERIAL AND METHODS Sex, age, serum folate levels, 
      plasma Hcy levels, and the time of Hcy and folate detection were obtained by 
      medical records. Univariate analysis and multi-factor mixed virtual linear 
      regression were used to explore the distribution and determinants of plasma Hcy 
      levels. RESULTS A total of 3031 participants (1091 men [35.99%] and 1940 women 
      [64.01%]) were included. The average levels of Hcy and the rates of 
      hyperhomocysteinemia (HHcy) in men were higher than those in women (P<0.05). Hcy 
      levels were observed to be lowest during autumn and highest during winter 
      (P<0.05). In the normal Hcy (NHcy) group, serum folate levels were higher than in 
      the HHcy group (P<0.05). Regression analysis suggested that sex, season, and 
      serum folate levels had an effect on Hcy levels, but age was not an influencing 
      factor of Hcy level in the preconception population. CONCLUSIONS This 
      retrospective study showed that Hcy levels are higher in men and in the winter 
      season. Sex, season, and serum folate levels were the influencing factors of Hcy 
      in the preconception population.
FAU - Wu, Manyu
AU  - Wu M
AD  - Department of Women's HealthCare, Affiliated Foshan Women and Children Hospital, 
      Southern Medical University, Foshan, Guangdong, China (mainland).
FAU - Huang, Xinyan
AU  - Huang X
AD  - Department of Women's HealthCare, Affiliated Foshan Women and Children Hospital, 
      Southern Medical University, Foshan, Guangdong, China (mainland).
FAU - Liu, Dan
AU  - Liu D
AD  - Department of Women's HealthCare, Affiliated Foshan Women and Children Hospital, 
      Southern Medical University, Foshan, Guangdong, China (mainland).
LA  - eng
PT  - Journal Article
DEP - 20221021
PL  - United States
TA  - Med Sci Monit
JT  - Medical science monitor : international medical journal of experimental and 
      clinical research
JID - 9609063
RN  - 935E97BOY8 (Folic Acid)
RN  - 0LVT1QZ0BA (Homocysteine)
SB  - IM
MH  - Humans
MH  - Male
MH  - Female
MH  - Retrospective Studies
MH  - *Folic Acid
MH  - *Hyperhomocysteinemia/complications
MH  - Homocysteine
MH  - China
PMC - PMC9595030
COIS- Conflict of interest: None declared
EDAT- 2022/10/22 06:00
MHDA- 2022/10/25 06:00
PMCR- 2022/10/21
CRDT- 2022/10/21 01:23
PHST- 2022/10/21 01:23 [entrez]
PHST- 2022/10/22 06:00 [pubmed]
PHST- 2022/10/25 06:00 [medline]
PHST- 2022/10/21 00:00 [pmc-release]
AID - 937987 [pii]
AID - 10.12659/MSM.937987 [doi]
PST - epublish
SO  - Med Sci Monit. 2022 Oct 21;28:e937987. doi: 10.12659/MSM.937987.