PMID- 36267222
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221022
IS  - 2035-8164 (Electronic)
IS  - 2035-8237 (Print)
IS  - 2035-8164 (Linking)
VI  - 14
IP  - 6
DP  - 2022
TI  - Osteosarcopenia and type 2 diabetes mellitus in post-menopausal women: a 
      case-control study.
PG  - 38570
LID - 10.52965/001c.38570 [doi]
LID - 38570
AB  - BACKGROUND: Osteosarcopenia has been defined as the concomitance of low bone 
      density (osteopenia/osteoporosis) and sarcopenia. Osteoporosis is characterized 
      by alterations in bone microarchitecture and decrease of bone mineral density 
      (BMD), whereas sarcopenia is the progressive decrease of both muscle mass and 
      function that increase the risk of falls. Type 2 diabetes mellitus (T2DM) is 
      associated with poor bone strength and muscle wasting. OBJECTIVE: The aim of this 
      study is to analyze the association between osteosarcopenia and T2DM in 
      post-menopausal women (PMW). METHODS: We performed an age matched case-control 
      study (1:2 ratio), considering as cases PMW affected by T2DM, and PMW without 
      T2DM as control group. For all patients a DXA evaluation to investigate bone 
      density and body composition measures were performed. Moreover, we carried out 
      muscle strength and performance assessments. Outcome measures were femoral neck 
      and lumbar spine BMD T-scores, appendicular lean mass (ALM), handgrip strength 
      and the Short Physical Performance Battery (SPPB). Data from both groups were 
      analyzed and compared. RESULTS: Thirty-six PMW (12 T2DM vs 24 non-T2DM) were 
      recruited. The frequency of osteosarcopenia was significantly higher in the T2DM 
      group compared to controls (50% vs 17%; OR 5.0, 95% CI 1.05 to 23.79, p = 0.043). 
      Handgrip strength was significantly lower in the T2DM group (10.09 +/- 4.02 kg vs 
      18.40 +/- 6.83 kg; p = 0.001). CONCLUSIONS: Post-menopausal women with T2DM have a 
      5 times higher risk to have osteosarcopenia compared to non-diabetic ones. 
      Further studies on larger cohorts are required to confirm these findings.
FAU - Moretti, Antimo
AU  - Moretti A
FAU - Palomba, Angela
AU  - Palomba A
FAU - Gimigliano, Francesca
AU  - Gimigliano F
FAU - Paoletta, Marco
AU  - Paoletta M
FAU - Liguori, Sara
AU  - Liguori S
FAU - Zanfardino, Francesco
AU  - Zanfardino F
FAU - Toro, Giuseppe
AU  - Toro G
FAU - Iolascon, Giovanni
AU  - Iolascon G
LA  - eng
PT  - Journal Article
DEP - 20221013
PL  - United States
TA  - Orthop Rev (Pavia)
JT  - Orthopedic reviews
JID - 101524779
PMC - PMC9568414
OTO - NOTNLM
OT  - diabetes mellitus
OT  - osteoporosis
OT  - osteosarcopenia
OT  - sarcopenia
COIS- The authors declare that they have no conflict of interest.
EDAT- 2022/10/22 06:00
MHDA- 2022/10/22 06:01
PMCR- 2022/10/13
CRDT- 2022/10/21 02:48
PHST- 2022/10/21 02:48 [entrez]
PHST- 2022/10/22 06:00 [pubmed]
PHST- 2022/10/22 06:01 [medline]
PHST- 2022/10/13 00:00 [pmc-release]
AID - 38570 [pii]
AID - 10.52965/001c.38570 [doi]
PST - epublish
SO  - Orthop Rev (Pavia). 2022 Oct 13;14(6):38570. doi: 10.52965/001c.38570. 
      eCollection 2022.