PMID- 36267318
OWN - NLM
STAT- MEDLINE
DCOM- 20221024
LR  - 20231211
IS  - 1748-6718 (Electronic)
IS  - 1748-670X (Print)
IS  - 1748-670X (Linking)
VI  - 2022
DP  - 2022
TI  - Influence of Narcotrend-Assisted Anesthesia In-Depth Monitor on Cognitive 
      Impairment of Elderly Patients under General Anesthesia.
PG  - 2866188
LID - 10.1155/2022/2866188 [doi]
LID - 2866188
AB  - OBJECTIVE: This research is designed to probe into the influence of Narcotrend- 
      (NT-) assisted anesthesia in-depth monitor on cognitive impairment of elderly 
      patients under general anesthesia (GA). METHODS: One hundred and forty-four 
      elderly patients with GA in our hospital from October 2020 to April 2021 were 
      randomized into two groups, namely, NT group (supervised anesthesia under NT 
      monitoring) and group C (anesthesia according to doctors' experience). The heart 
      rate (HR), mean arterial pressure (MAP), and central venous pressure (CVP) were 
      recorded before surgery (T0), at the beginning of surgery (T1), at the end of 
      surgery (T2), and 1 day after surgery (T3). Serum of patients was obtained at 
      these four time points for measurements of C-reactive protein (CRP), 
      interleukin-6 (IL-6), and cortisol (Cor) levels using the enzyme-linked 
      immunosorbent assay (ELISA). The alterations in cognitive function pre- and 
      post-anesthesia were assessed using the mini-mental state examination (MMSE), and 
      adverse events (AEs) during anesthesia recovery, postoperative recovery, and 
      dosage of anesthetics were recorded. RESULTS: At T1 and T2, MAP was higher and 
      CVP was lower in NT group, versus group C. NT group presented higher CRP, IL-6, 
      and Cor than group C at T1-T3. MMSE scores were higher in TN group than in group 
      C at 12, 24, and 48 h after surgery. The incidence rates of postoperative 
      cognitive dysfunction (POCD) and total AEs in group C were noticeably higher than 
      those in NT group. Compared with group C, the time of anesthesia recovery, 
      extubation, and postanesthesia care unit (PACU) residence in NT group reduced 
      remarkably. CONCLUSIONS: NT has little effect on the physical condition of 
      elderly patients under GA, and can reduce the dosage of narcotic drugs and 
      promote the recovery of patients from anesthesia, which has high clinical value.
CI  - Copyright (c) 2022 Maoyong Tu et al.
FAU - Tu, Maoyong
AU  - Tu M
AD  - Department of Anesthesia, The First Affiliated Hospital of Anhui Medical 
      University, Hefei, Anhui 230022, China.
AD  - Department of Anesthesia, The Second People's Hospital of Hefei, Hefei, Anhui 
      230011, China.
FAU - Zhang, Qing
AU  - Zhang Q
AD  - Department of Anesthesia, The Second People's Hospital of Hefei, Hefei, Anhui 
      230011, China.
FAU - Liu, Xuesheng
AU  - Liu X
AUID- ORCID: 0000-0002-4996-9889
AD  - Department of Anesthesia, The First Affiliated Hospital of Anhui Medical 
      University, Hefei, Anhui 230022, China.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Retracted Publication
DEP - 20221011
PL  - United States
TA  - Comput Math Methods Med
JT  - Computational and mathematical methods in medicine
JID - 101277751
RN  - 0 (Interleukin-6)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - WI4X0X7BPJ (Hydrocortisone)
RN  - 0 (Anesthetics)
RN  - 0 (Narcotics)
SB  - IM
RIN - Comput Math Methods Med. 2023 Nov 29;2023:9803619. PMID: 38077882
MH  - Humans
MH  - Aged
MH  - Interleukin-6
MH  - C-Reactive Protein
MH  - Hydrocortisone
MH  - Anesthesia, General/adverse effects
MH  - *Cognitive Dysfunction/epidemiology/etiology
MH  - *Anesthetics
MH  - Narcotics
PMC - PMC9578890
COIS- The authors have no conflicts of interest to declare.
EDAT- 2022/10/22 06:00
MHDA- 2022/10/25 06:00
PMCR- 2022/10/11
CRDT- 2022/10/21 02:50
PHST- 2022/08/23 00:00 [received]
PHST- 2022/09/29 00:00 [accepted]
PHST- 2022/10/21 02:50 [entrez]
PHST- 2022/10/22 06:00 [pubmed]
PHST- 2022/10/25 06:00 [medline]
PHST- 2022/10/11 00:00 [pmc-release]
AID - 10.1155/2022/2866188 [doi]
PST - epublish
SO  - Comput Math Methods Med. 2022 Oct 11;2022:2866188. doi: 10.1155/2022/2866188. 
      eCollection 2022.