PMID- 36267617 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20221022 IS - 2296-858X (Print) IS - 2296-858X (Electronic) IS - 2296-858X (Linking) VI - 9 DP - 2022 TI - Effectiveness of acupuncture combined with rehabilitation training vs. rehabilitation training alone for post-stroke shoulder pain: A systematic review and meta-analysis of randomized controlled trials. PG - 947285 LID - 10.3389/fmed.2022.947285 [doi] LID - 947285 AB - BACKGROUND: Post-stroke shoulder pain (PSSP) is characterized by shoulder pain on the hemiplegic side, which can limit physical activity in patients with stroke. Acupuncture combined with rehabilitation training (AR) has been widely used in PSSP, but the evidence of its effectiveness is still unclear. OBJECTIVE: The study aimed to evaluate the effect and safety of AR vs. rehabilitation training (RT) alone on PSSP. METHODS: We searched PubMed, the Cochrane Library, the Chinese Biological Medicine Database (CBM), the Chinese Scientific Journal Database (VIP), China National Knowledge Infrastructure (CNKI), and the WAN FANG database for relevant studies from their inception to February 2022. Only randomized controlled trials (RCTs) comparing the effect of AR with RT alone on PSSP were considered. The primary outcome was shoulder pain. Secondary outcomes included upper limb motor function, activities of daily living (ADL), shoulder range of motion (ROM), and adverse events (AEs). Subgroup analysis and sensitivity analysis were also conducted. Quality assessment was implemented based on Cochrane risk of bias (ROB) criteria, which consist of seven items. When more than four items in a study were judged as low ROB, the overall quality of this study was considered low risk. RESULTS: A total of 40 studies were included in the qualitative analysis, and 35 (87.5%) studies with 2,554 patients were included in the meta-analysis. Of the 40 studies, 14 (35.0%) were of moderate-to-high quality. The meta-analysis results showed that AR is better than RT alone in reducing shoulder pain (MD -1.32, 95% CI -1.58 to -1.07), improving upper limb motor function (MD 6.81, 95% CI 4.95-8.67), ADL (MD 11.17, 95% CI 9.44-12.91), and shoulder ROM (internal rotation: MD 10.48, 95% CI 8.14-12.83; backward extension: MD 7.82, 95% CI 6.00-9.64; anteflexion: MD 12.88, 95% CI 5.47-20.29; external rotation: MD 11.40, 95% CI 6.17-16.64; abduction: MD 16.96, 95% CI 8.61-25.31) without obvious AEs. CONCLUSION: AR may be better than RT alone for the improvement of shoulder pain, upper limb motor function, ADL, and shoulder ROM, without obvious AEs in patients with PSSP. However, considering the clinical and statistical heterogeneity, our findings need to be interpreted with caution. More rigorous RCTs in this area should be conducted in the future. SYSTEMATIC REVIEW REGISTRATION: [www.crd.york.ac.uk], identifier [CRD42022326763]. CI - Copyright (c) 2022 Zhan, Wei, Tao, Yan, Zhang, Chen, Dong, Chen, Liu and Lu. FAU - Zhan, Jie AU - Zhan J AD - Postdoctoral Research Station, Department of Rehabilitation, Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China. AD - Clinical Research and Data Center, South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, China. AD - Department of Rehabilitation, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China. FAU - Wei, Xiaojing AU - Wei X AD - Clinical Research and Data Center, South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, China. FAU - Tao, Chenyang AU - Tao C AD - Clinical Research and Data Center, South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, China. FAU - Yan, Xiaoting AU - Yan X AD - Clinical Research and Data Center, South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, China. FAU - Zhang, Peiming AU - Zhang P AD - Clinical Research and Data Center, South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, China. FAU - Chen, Rouhao AU - Chen R AD - Clinical Research and Data Center, South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, China. FAU - Dong, Yu AU - Dong Y AD - Clinical Research and Data Center, South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, China. FAU - Chen, Hongxia AU - Chen H AD - Department of Rehabilitation, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China. FAU - Liu, Jianhua AU - Liu J AD - Research Team for Acupuncture Effect and Mechanism, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China. FAU - Lu, Liming AU - Lu L AD - Clinical Research and Data Center, South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, China. LA - eng PT - Systematic Review DEP - 20221004 PL - Switzerland TA - Front Med (Lausanne) JT - Frontiers in medicine JID - 101648047 PMC - PMC9578557 OTO - NOTNLM OT - acupuncture OT - alternative and complementary medicine OT - meta-analysis OT - post-stroke shoulder pain OT - rehabilitation training COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2022/10/22 06:00 MHDA- 2022/10/22 06:01 PMCR- 2022/10/04 CRDT- 2022/10/21 02:57 PHST- 2022/05/18 00:00 [received] PHST- 2022/08/31 00:00 [accepted] PHST- 2022/10/21 02:57 [entrez] PHST- 2022/10/22 06:00 [pubmed] PHST- 2022/10/22 06:01 [medline] PHST- 2022/10/04 00:00 [pmc-release] AID - 10.3389/fmed.2022.947285 [doi] PST - epublish SO - Front Med (Lausanne). 2022 Oct 4;9:947285. doi: 10.3389/fmed.2022.947285. eCollection 2022.