PMID- 36269593
OWN - NLM
STAT- MEDLINE
DCOM- 20221111
LR  - 20221111
IS  - 1557-8674 (Electronic)
IS  - 1096-2964 (Linking)
VI  - 23
IP  - 9
DP  - 2022 Nov
TI  - Parvovirus B19-Associated Severe Anemia in Adult Liver Transplant Recipients: A 
      Case Series and Review of the Literature.
PG  - 848-856
LID - 10.1089/sur.2022.186 [doi]
AB  - Background: Parvovirus B19 (B19V) infection is a rare cause of severe anemia in 
      liver transplant recipients. However, few studies have systematically reviewed 
      reported cases and summarized experience in managing this disease. Objective: We 
      described a retrospective case series of eight adult liver transplant recipients 
      with B19V-associated severe anemia and performed a literature review of 
      epidemiology, etiology, clinical courses, diagnosis, treatment options available, 
      and outcomes of B19V-associated anemia in adult liver transplant recipients. 
      Patients and Methods: We systematically reviewed articles describing adult liver 
      transplant recipients with B19V-associated anemia from PubMed and ScienceDirect 
      databases from database inception to May 2022. Results: Eight articles containing 
      23 cases were identified in addition to eight cases from our center for a total 
      of 31 patients (mean age, 45.7 +/- 9.7 years; 74.2% male). Eighty-seven percent 
      developed transfusion-dependent anemia within two months after liver 
      transplantation (LT). Fever and progressive anemia are among the major 
      manifestations. Intravenous immunoglobulin (IVIG)-based therapy was given to all 
      patients and the treatment protocols varied among different centers. Except for 
      two cases who died of comorbidities, 17 patients obtained long-term recovery from 
      anemia after one course of treatment and six (19%) experienced relapses that were 
      reversed by repeated courses of IVIG therapy. Two recipients presented with 
      IVIG-associated side effects and two developed acute cellular rejection (ACR) 
      after reduction of immunosuppression. Conclusions: B19V infection should be 
      suspected early as a cause of severe anemia of unknown etiology in adult liver 
      transplant recipients. The clearance of B19V typically lags behind recovery of 
      anemia, and inadequate clearance of virus after cessation of IVIG appears to be a 
      potential risk of anemia recurrence. Moreover, more attention should be paid to 
      the side effects of high-dose IVIG infusion and ACR because of reduction of 
      immunosuppression.
FAU - Cheng, Pengrui
AU  - Cheng P
AD  - Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, 
      Guangzhou, China.
AD  - Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, 
      The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
AD  - Guangdong Provincial International Cooperation Base of Science and Technology 
      (Organ Transplantation), The First Affiliated Hospital, Sun Yat-sen University, 
      Guangzhou, China.
FAU - Jian, Qian
AU  - Jian Q
AD  - Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, 
      Guangzhou, China.
AD  - Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, 
      The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
AD  - Guangdong Provincial International Cooperation Base of Science and Technology 
      (Organ Transplantation), The First Affiliated Hospital, Sun Yat-sen University, 
      Guangzhou, China.
FAU - Fu, Zongli
AU  - Fu Z
AD  - Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, 
      Guangzhou, China.
AD  - Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, 
      The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
AD  - Guangdong Provincial International Cooperation Base of Science and Technology 
      (Organ Transplantation), The First Affiliated Hospital, Sun Yat-sen University, 
      Guangzhou, China.
FAU - Ma, Yi
AU  - Ma Y
AD  - Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, 
      Guangzhou, China.
AD  - Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, 
      The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
AD  - Guangdong Provincial International Cooperation Base of Science and Technology 
      (Organ Transplantation), The First Affiliated Hospital, Sun Yat-sen University, 
      Guangzhou, China.
LA  - eng
PT  - Journal Article
PT  - Systematic Review
DEP - 20221020
PL  - United States
TA  - Surg Infect (Larchmt)
JT  - Surgical infections
JID - 9815642
RN  - 0 (Immunoglobulins, Intravenous)
SB  - IM
MH  - Adult
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Female
MH  - *Parvovirus B19, Human
MH  - *Parvoviridae Infections/epidemiology/complications/therapy
MH  - Immunoglobulins, Intravenous/therapeutic use
MH  - *Liver Transplantation/adverse effects
MH  - Retrospective Studies
MH  - *Anemia/epidemiology/etiology
OTO - NOTNLM
OT  - anemia
OT  - intravenous immunoglobulin
OT  - liver transplantation
OT  - parvovirus B19
OT  - post-transplant infection
EDAT- 2022/10/22 06:00
MHDA- 2022/11/15 06:00
CRDT- 2022/10/21 12:02
PHST- 2022/10/22 06:00 [pubmed]
PHST- 2022/11/15 06:00 [medline]
PHST- 2022/10/21 12:02 [entrez]
AID - 10.1089/sur.2022.186 [doi]
PST - ppublish
SO  - Surg Infect (Larchmt). 2022 Nov;23(9):848-856. doi: 10.1089/sur.2022.186. Epub 
      2022 Oct 20.