PMID- 36271282 OWN - NLM STAT- MEDLINE DCOM- 20221025 LR - 20230117 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 12 IP - 1 DP - 2022 Oct 21 TI - Serum kisspeptin and proopiomelanocortin in cystic fibrosis: a single study. PG - 17669 LID - 10.1038/s41598-022-21851-8 [doi] LID - 17669 AB - The determination of hormonal biomarkers is of increasing interest in many diseases, including cystic fibrosis (CF). Hormones that have not been estimated and described so far in CF include kisspeptin (KISS) and proopiomelanocortin (POMC), which are involved in the regulation of many processes, including appetite and fertility. Therefore, the aim of our study was to estimate the level of KISS and POMC in sera from CF patients and to determine the correlation between these hormones and clinical parameters. For this purpose, we estimated the levels of KISS and POMC in 38 CF patients and 16 healthy participants with enzyme-linked immunosorbent assay. We found significantly reduced levels of KISS and POMC in people with CF compared to healthy subjects (1.76 +/- 0.46 vs. 2.27 +/- 0.56 ng/mL, p < 0.05 and 6.25 +/- 4.36 vs. 14.74 +/- 6.24 ng/mL, p < 0.001, respectively). Furthermore, the level of both hormones was negatively correlated with age. The hormones studied did not correlate with the results of spirometry and each other. Thus, decreased KISS and POMC levels may be associated with lower body weight and delayed puberty in patients with CF. CI - (c) 2022. The Author(s). FAU - Galiniak, Sabina AU - Galiniak S AD - Institute of Medical Sciences, Medical College, Rzeszow University, Rzeszow, Poland. sgaliniak@ur.edu.pl. FAU - Podgorski, Rafal AU - Podgorski R AD - Institute of Medical Sciences, Medical College, Rzeszow University, Rzeszow, Poland. FAU - Rachel, Marta AU - Rachel M AD - Institute of Medical Sciences, Medical College, Rzeszow University, Rzeszow, Poland. FAU - Mazur, Artur AU - Mazur A AD - Institute of Medical Sciences, Medical College, Rzeszow University, Rzeszow, Poland. LA - eng PT - Journal Article DEP - 20221021 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 RN - 0 (Kisspeptins) RN - 66796-54-1 (Pro-Opiomelanocortin) RN - 0 (Biomarkers) SB - IM MH - Humans MH - *Kisspeptins MH - Pro-Opiomelanocortin MH - *Cystic Fibrosis MH - Thinness MH - Biomarkers PMC - PMC9586927 COIS- The authors declare no competing interests. EDAT- 2022/10/23 06:00 MHDA- 2022/10/26 06:00 PMCR- 2022/10/21 CRDT- 2022/10/22 00:11 PHST- 2022/06/29 00:00 [received] PHST- 2022/10/04 00:00 [accepted] PHST- 2022/10/23 06:00 [pubmed] PHST- 2022/10/26 06:00 [medline] PHST- 2022/10/22 00:11 [entrez] PHST- 2022/10/21 00:00 [pmc-release] AID - 10.1038/s41598-022-21851-8 [pii] AID - 21851 [pii] AID - 10.1038/s41598-022-21851-8 [doi] PST - epublish SO - Sci Rep. 2022 Oct 21;12(1):17669. doi: 10.1038/s41598-022-21851-8.