PMID- 36272476
OWN - NLM
STAT- MEDLINE
DCOM- 20221124
LR  - 20221124
IS  - 1879-1026 (Electronic)
IS  - 0048-9697 (Linking)
VI  - 857
IP  - Pt 2
DP  - 2023 Jan 20
TI  - Neuro- and hepato-toxicity of polystyrene nanoplastics and polybrominated 
      diphenyl ethers on early life stages of zebrafish.
PG  - 159567
LID - S0048-9697(22)06666-9 [pii]
LID - 10.1016/j.scitotenv.2022.159567 [doi]
AB  - Nanoplastics (NPs) are good carriers of persistent organic pollutants (POPs) such 
      as polybrominated diphenyl ethers (PBDEs) and can modify their bioavailability 
      and toxicity to aquatic organisms. This study highlights the single and combined 
      toxic effects of polystyrene nanoplastics (PS-NPs) and 2,2 ',4,4 
      '-tetrabromodiphenyl ether (BDE-47, one of the major PBDE congeners) on zebrafish 
      embryos after an exposure of up to 120 hpf. Our results showed that PS-NPs and 
      BDE-47 formed larger particle aggregates during co-exposure, which attached to 
      the surface of the yolk membrane and even changed its structure, and these 
      particles also bioaccumulated in the intestine of zebrafish larvae, compared with 
      the PS-NPs single exposure. Further, the co-exposure significantly increased 
      mortality, accelerated voluntary movements, enhanced hatching rate, and decreased 
      heart rate. Hepatoxicity analyses revealed that the mixture exposure induced a 
      darker/browner liver colour, atrophied liver and greater hepatotoxicity in 
      zebrafish larvae. In addition to increased ROS accumulation, the reduced 
      expression of the antioxidant gpx1a gene and increased expression of cyp1a1 were 
      found after co-treatment. Moreover, ache and chrn7alpha genes associated with 
      neurocentral development, were significantly downregulated, mainly in the 
      co-exposure group. In conclusion, simultaneous exposure to PS-NPs and BDE-47 
      exacerbated oxidative stress, developmental impacts, hepatotoxicity, and 
      neurodevelopmental toxicity in zebrafish larvae. Therefore, neurotoxic effects of 
      complex chemical interactions between PS-NPs and persistent organic pollutants in 
      freshwater environments should be paid more attention.
CI  - Copyright (c) 2022 Elsevier B.V. All rights reserved.
FAU - Wang, Qiuping
AU  - Wang Q
AD  - College of Marine Sciences, South China Agricultural University, Guangzhou 
      510642, China.
FAU - Chen, Guanglong
AU  - Chen G
AD  - Institute of Eco-Environmental Research, Guangxi Academy of Sciences, Nanning 
      530007, China.
FAU - Tian, Liyan
AU  - Tian L
AD  - College of Marine Sciences, South China Agricultural University, Guangzhou 
      510642, China.
FAU - Kong, Chunmiao
AU  - Kong C
AD  - College of Marine Sciences, South China Agricultural University, Guangzhou 
      510642, China.
FAU - Gao, Dandan
AU  - Gao D
AD  - College of Marine Sciences, South China Agricultural University, Guangzhou 
      510642, China.
FAU - Chen, Yurou
AU  - Chen Y
AD  - College of Marine Sciences, South China Agricultural University, Guangzhou 
      510642, China.
FAU - Junaid, Muhammad
AU  - Junaid M
AD  - College of Marine Sciences, South China Agricultural University, Guangzhou 
      510642, China.
FAU - Wang, Jun
AU  - Wang J
AD  - College of Marine Sciences, South China Agricultural University, Guangzhou 
      510642, China; Institute of Eco-Environmental Research, Guangxi Academy of 
      Sciences, Nanning 530007, China.; Southern Marine Science and Engineering 
      Guangdong Laboratory (Zhuhai), Guangzhou 510006, China. Electronic address: 
      wangjun2016@scau.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20221020
PL  - Netherlands
TA  - Sci Total Environ
JT  - The Science of the total environment
JID - 0330500
RN  - 0N97R5X10X (2,2',4,4'-tetrabromodiphenyl ether)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (Polystyrenes)
RN  - 0 (Microplastics)
RN  - 0 (Persistent Organic Pollutants)
RN  - 0 (Water Pollutants, Chemical)
SB  - IM
MH  - Animals
MH  - Halogenated Diphenyl Ethers/toxicity/metabolism
MH  - Zebrafish/metabolism
MH  - Polystyrenes/toxicity/metabolism
MH  - Microplastics/toxicity
MH  - Persistent Organic Pollutants
MH  - *Water Pollutants, Chemical/metabolism
MH  - Larva
MH  - *Chemical and Drug Induced Liver Injury
OTO - NOTNLM
OT  - Developmental neurotoxicity
OT  - Nanoplastics
OT  - PBDE
OT  - ROS
OT  - Zebrafish
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2022/10/23 06:00
MHDA- 2022/11/25 06:00
CRDT- 2022/10/22 19:23
PHST- 2022/09/02 00:00 [received]
PHST- 2022/09/29 00:00 [revised]
PHST- 2022/10/15 00:00 [accepted]
PHST- 2022/10/23 06:00 [pubmed]
PHST- 2022/11/25 06:00 [medline]
PHST- 2022/10/22 19:23 [entrez]
AID - S0048-9697(22)06666-9 [pii]
AID - 10.1016/j.scitotenv.2022.159567 [doi]
PST - ppublish
SO  - Sci Total Environ. 2023 Jan 20;857(Pt 2):159567. doi: 
      10.1016/j.scitotenv.2022.159567. Epub 2022 Oct 20.