PMID- 36272701
OWN - NLM
STAT- MEDLINE
DCOM- 20221125
LR  - 20221226
IS  - 1521-7035 (Electronic)
IS  - 1521-6616 (Linking)
VI  - 245
DP  - 2022 Dec
TI  - Long non-coding RNA: Multiple effects on the differentiation, maturity and cell 
      function of dendritic cells.
PG  - 109167
LID - S1521-6616(22)00248-0 [pii]
LID - 10.1016/j.clim.2022.109167 [doi]
AB  - Long non-coding RNAs (LncRNAs), lacking protein-coding function, modulate immune 
      function by regulating the expression of genes or the function of protein 
      molecules. They participate in epigenetic regulation, interfere with downstream 
      gene transcription acting as a molecular sponge to affect miRNA function, and can 
      combine with proteins to form nucleic acid protein complexes that affect protein 
      function or cell location to regulate genes and regulate immune function. LncRNAs 
      are differentially expressed in immune cells. They affect the maturity, 
      differentiation and activation of immune cells and regulate cytokine release and 
      immune phenotype. They are closely related to immune tolerance and cell 
      migration. Dendritic cells (DCs) are important immune cells with the most robust 
      antigen-presenting function, and have irreplaceable roles in human innate 
      immunity and adaptive immunity. Emerging evidence over the past few years has 
      suggested that LncRNAs influence the differentiation and maturation of DCs and 
      serve as a critical role in the cell phenotype and immune function of DCs. To 
      further understand the role of LncRNAs in the occurrence and development of 
      DC-related diseases, we elaborated the role of LncRNAs in DC immune function, 
      including antigen presentation, T cell activation and proliferation, DC 
      migration. Furthermore, we summarized the impact of pathological factors (tumors, 
      inflammation, autoimmune disease, viral infection) and physiological factors 
      (e.g., age) on the LncRNAs in DCs, and how the changed LncRNAs altered the 
      function and behavior of DCs resulting from the intervention. We hope this review 
      give us have a better understanding of multiple effects of LncRNA on cell 
      function in DCs.
CI  - Copyright (c) 2022 Elsevier Inc. All rights reserved.
FAU - Liu, Xinyu
AU  - Liu X
AD  - Department of Pathogen Biology and Immunology, Medical College of Nanchang 
      University, Nanchang 330006, China; Center for Reproductive Medicine, Cheeloo 
      College of Medicine, Shandong University, Jinan 250012, China; Second Clinical 
      Medical College of Nanchang University, Nanchang 330006, China.
FAU - Li, Yuanheng
AU  - Li Y
AD  - Queen Mary School of Nanchang University, Nanchang 330031, China.
FAU - Jiang, Xiaoying
AU  - Jiang X
AD  - Department of Pathogen Biology and Immunology, Medical College of Nanchang 
      University, Nanchang 330006, China.
FAU - Deng, Yu'en
AU  - Deng Y
AD  - Huankui Academy of Nanchang University, Nanchang 330031, China.
FAU - Ma, Chuanwei
AU  - Ma C
AD  - Department of Pathogen Biology and Immunology, Medical College of Nanchang 
      University, Nanchang 330006, China.
FAU - Yu, Qiongfang
AU  - Yu Q
AD  - Department of Gastroenterology and Hepatology, Second Affiliated Hospital of 
      Nanchang University, Nanchang, Jiangxi 330006, China.
FAU - Gao, Dian
AU  - Gao D
AD  - Department of Pathogen Biology and Immunology, Medical College of Nanchang 
      University, Nanchang 330006, China. Electronic address: gaodian@ncu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20221019
PL  - United States
TA  - Clin Immunol
JT  - Clinical immunology (Orlando, Fla.)
JID - 100883537
RN  - 0 (RNA, Long Noncoding)
RN  - 0 (MicroRNAs)
SB  - IM
MH  - Humans
MH  - *RNA, Long Noncoding/genetics/metabolism
MH  - Dendritic Cells
MH  - Epigenesis, Genetic
MH  - Cell Differentiation
MH  - *MicroRNAs/metabolism
OTO - NOTNLM
OT  - Dendritic cells
OT  - Differentiation
OT  - Immune function
OT  - LncRNAs
OT  - Regulatory function
COIS- Declaration of Competing Interest None.
EDAT- 2022/10/23 06:00
MHDA- 2022/11/26 06:00
CRDT- 2022/10/22 19:35
PHST- 2022/03/16 00:00 [received]
PHST- 2022/07/29 00:00 [revised]
PHST- 2022/10/15 00:00 [accepted]
PHST- 2022/10/23 06:00 [pubmed]
PHST- 2022/11/26 06:00 [medline]
PHST- 2022/10/22 19:35 [entrez]
AID - S1521-6616(22)00248-0 [pii]
AID - 10.1016/j.clim.2022.109167 [doi]
PST - ppublish
SO  - Clin Immunol. 2022 Dec;245:109167. doi: 10.1016/j.clim.2022.109167. Epub 2022 Oct 
      19.