PMID- 36272753
OWN - NLM
STAT- MEDLINE
DCOM- 20221025
LR  - 20221213
IS  - 1523-1755 (Electronic)
IS  - 0085-2538 (Linking)
VI  - 102
IP  - 5
DP  - 2022 Nov
TI  - Endothelium and endothelin: regulators of arterial stiffness and fibrinolysis in 
      ANCA-associated vasculitis.
PG  - 963-966
LID - S0085-2538(22)00726-8 [pii]
LID - 10.1016/j.kint.2022.08.029 [doi]
AB  - In this issue, Farrah et al. report clinical investigations in patients with 
      antineutrophil cytoplasmic antibody-associated vasculitis (AAV). They demonstrate 
      that endothelium-dependent vasodilatation, fibrinolytic capacity, and 
      monocyte-dependent endothelin-1 clearance are reduced in patients with AAV, 
      whereas circulating levels of endothelin-1 and vascular stiffness are increased. 
      Acute infusion of an endothelin ET(A) receptor antagonist reduced 
      vasoconstriction and arterial stiffness. This Commentary discusses biological 
      insights and clinical implications of this study.
CI  - Copyright (c) 2022 International Society of Nephrology. Published by Elsevier Inc. 
      All rights reserved.
FAU - Barton, Matthias
AU  - Barton M
AD  - Molecular Medicine, University of Zurich, Zurich, Switzerland; Andreas Gruntzig 
      Foundation, Zurich, Switzerland. Electronic address: barton@access.uzh.ch.
LA  - eng
PT  - Comment
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Kidney Int
JT  - Kidney international
JID - 0323470
RN  - 0 (Antibodies, Antineutrophil Cytoplasmic)
RN  - 0 (Endothelin-1)
RN  - 0 (Endothelins)
SB  - IM
CON - Kidney Int. 2022 Nov;102(5):1115-1126. PMID: 35998848
MH  - Humans
MH  - *Vascular Stiffness
MH  - Antibodies, Antineutrophil Cytoplasmic
MH  - Endothelin-1
MH  - Fibrinolysis
MH  - *Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/drug therapy
MH  - Endothelins
MH  - Endothelium
EDAT- 2022/10/23 06:00
MHDA- 2022/10/26 06:00
CRDT- 2022/10/22 21:03
PHST- 2022/08/04 00:00 [received]
PHST- 2022/08/13 00:00 [revised]
PHST- 2022/08/15 00:00 [accepted]
PHST- 2022/10/22 21:03 [entrez]
PHST- 2022/10/23 06:00 [pubmed]
PHST- 2022/10/26 06:00 [medline]
AID - S0085-2538(22)00726-8 [pii]
AID - 10.1016/j.kint.2022.08.029 [doi]
PST - ppublish
SO  - Kidney Int. 2022 Nov;102(5):963-966. doi: 10.1016/j.kint.2022.08.029.