PMID- 36276084 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20221025 IS - 2234-943X (Print) IS - 2234-943X (Electronic) IS - 2234-943X (Linking) VI - 12 DP - 2022 TI - Outcomes with mismatched unrelated donor allogeneic hematopoietic stem cell transplantation in adults: A systematic review and meta-analysis. PG - 1005042 LID - 10.3389/fonc.2022.1005042 [doi] LID - 1005042 AB - BACKGROUND: Allogeneic hematopoietic stem cell transplantation (HSCT) is a potentially curative therapy for various hematologic disorders. Alternative donor strategies such as mismatched unrelated donors (MMUD) offer the option of HSCT to patients lacking a human leukocyte antigen (HLA)-matched donor. We conducted a systematic review and meta-analysis to evaluate outcomes after MMUD-HSCT. METHODS: A literature search was performed on PubMed, Cochrane Library, and ClinicalTrials.gov from the inception date through April 6, 2022. After screening 2477 manuscripts, 19 studies were included. Data was extracted following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Pooled analysis was done using the meta-package by Schwarzer et al. Proportions with 95% confidence intervals (CI) were computed. RESULTS: A total of 3336 patients from 19 studies were included. The median age was 52.1 years, and 53% of recipients were males. The graft source was bone marrow in 19% and peripheral blood stem cells in 81% of recipients. The median time to transplant from hematologic diagnosis was 10 (1-247) months. Hematologic diagnoses included myeloid (82.9%), lymphoid (41.1%), and other disorders (3%). The reduced intensity and myeloablative conditioning were used in 65.6% and 32% of recipients, respectively. In-vivo T-cell depletion was performed in 56.7% of the patients. Most patients had one (87.9%) or two (11.4%) antigen HLA-mismatch. The pooled 1-year overall survival (OS) was 63.9% (95% CI 0.57-0.71, n=1426/2706), and the pooled 3-year OS was 42.1% (95% CI 0.34.2-0.50, n=907/2355). The pooled progression-free survival was 46.6% (95% CI 0.39-0.55, n=1295/3253) after a median follow-up of 1.8 (range 1-6) years. The pooled relapse rate was 26.8% (95% CI 0.22-0.32, n=972/3253) after a median follow-up of 2.25 (1-3) years. The pooled incidence of acute (grade II-IV) graft-versus-host disease (GVHD) and chronic GVHD was 36.4% (95% CI 0.31-0.42, n=1131/3030) and 41.2% (95% CI 0.35-0.48, n=1337/3228), respectively. The pooled non-relapse mortality was 22.6% (95% CI 0.17-0.29, n=888/3196) after a median follow-up of 2.6 (1-5) years. CONCLUSION: MMUD-HSCT has demonstrated favorable outcomes with an acceptable toxicity profile. It represents a promising option in patients lacking an HLA-matched or haploidentical donor and may expand HSCT access to underrepresented racial and ethnic populations. CI - Copyright (c) 2022 Mushtaq, Shahzad, Tariq, Iqbal, Chaudhary, Zafar, Anwar, Ahmed, Bansal, Singh, Abhyankar, Callander, Hematti and McGuirk. FAU - Mushtaq, Muhammad Umair AU - Mushtaq MU AD - Division of Hematologic Malignancies and Cellular Therapeutics, University of Kansas Medical Center, Kansas City, KS, United States. FAU - Shahzad, Moazzam AU - Shahzad M AD - Division of Hematologic Malignancies and Cellular Therapeutics, University of Kansas Medical Center, Kansas City, KS, United States. AD - Moffitt Cancer Center, University of South Florida, Tampa, FL, United States. FAU - Tariq, Ezza AU - Tariq E AD - Division of Hematologic Malignancies and Cellular Therapeutics, University of Kansas Medical Center, Kansas City, KS, United States. AD - Department of Medicine, University of Toledo Medical Center, Toledo, OH, United States. FAU - Iqbal, Qamar AU - Iqbal Q AD - Division of Hematologic Malignancies and Cellular Therapeutics, University of Kansas Medical Center, Kansas City, KS, United States. FAU - Chaudhary, Sibgha Gull AU - Chaudhary SG AD - Division of Hematologic Malignancies and Cellular Therapeutics, University of Kansas Medical Center, Kansas City, KS, United States. FAU - Zafar, Muhammad U AU - Zafar MU AD - Division of Hematologic Malignancies and Cellular Therapeutics, University of Kansas Medical Center, Kansas City, KS, United States. FAU - Anwar, Iqra AU - Anwar I AD - Division of Hematologic Malignancies and Cellular Therapeutics, University of Kansas Medical Center, Kansas City, KS, United States. FAU - Ahmed, Nausheen AU - Ahmed N AD - Division of Hematologic Malignancies and Cellular Therapeutics, University of Kansas Medical Center, Kansas City, KS, United States. FAU - Bansal, Rajat AU - Bansal R AD - Division of Hematologic Malignancies and Cellular Therapeutics, University of Kansas Medical Center, Kansas City, KS, United States. FAU - Singh, Anurag K AU - Singh AK AD - Division of Hematologic Malignancies and Cellular Therapeutics, University of Kansas Medical Center, Kansas City, KS, United States. FAU - Abhyankar, Sunil H AU - Abhyankar SH AD - Division of Hematologic Malignancies and Cellular Therapeutics, University of Kansas Medical Center, Kansas City, KS, United States. FAU - Callander, Natalie S AU - Callander NS AD - School of Medicine and Public Health, University of Wisconsin, Madison, WI, United States. FAU - Hematti, Peiman AU - Hematti P AD - School of Medicine and Public Health, University of Wisconsin, Madison, WI, United States. FAU - McGuirk, Joseph P AU - McGuirk JP AD - Division of Hematologic Malignancies and Cellular Therapeutics, University of Kansas Medical Center, Kansas City, KS, United States. LA - eng PT - Systematic Review DEP - 20221006 PL - Switzerland TA - Front Oncol JT - Frontiers in oncology JID - 101568867 PMC - PMC9583270 OTO - NOTNLM OT - HLA matching in bone marrow transplantation OT - allogeneic hematopoietic stem cell transplantation OT - donor selection OT - hematologic malignancies OT - mismatched unrelated donor OT - outcomes COIS- SA has speaking, consulting and advisory role, and research funding from Incyte and Therakos. JM has speaking, consulting and advisory role in Kite, Juno Therapeutics, Allovir, Magenta Therapeutics, EcoR1 Capital, and has research funding from Novartis, Fresenius Biotech, Astellas Pharma, Bellicum Pharmaceuticals, Gamida Cell, Pluristem Therapeutics, Kite and AlloVir. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2022/10/25 06:00 MHDA- 2022/10/25 06:01 PMCR- 2022/01/01 CRDT- 2022/10/24 04:11 PHST- 2022/07/27 00:00 [received] PHST- 2022/09/15 00:00 [accepted] PHST- 2022/10/24 04:11 [entrez] PHST- 2022/10/25 06:00 [pubmed] PHST- 2022/10/25 06:01 [medline] PHST- 2022/01/01 00:00 [pmc-release] AID - 10.3389/fonc.2022.1005042 [doi] PST - epublish SO - Front Oncol. 2022 Oct 6;12:1005042. doi: 10.3389/fonc.2022.1005042. eCollection 2022.