PMID- 36276511
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221025
IS  - 2036-2579 (Electronic)
IS  - 1826-1868 (Print)
IS  - 1826-1868 (Linking)
VI  - 14
IP  - 2
DP  - 2020
TI  - Prolonged Extracorporeal Membrane Oxygenation Support In a Patient with Drug 
      Reaction with Eosinophilia and Systemic Symptoms Syndrome-associated Fulminant 
      Myocarditis - A Case Report and Literature Review.
PG  - 112-117
LID - 10.17925/HI.2020.14.2.112 [doi]
AB  - Introduction: Myocarditis is a rare presentation of drug reaction with 
      eosinophilia and systemic symptoms (DRESS) syndrome, traditionally associated 
      with poor clinical outcomes. Prompt recognition and treatment are crucial. Case 
      presentation: A 16-year-old patient presented with acute chest pain, hypotension, 
      and pulmonary oedema 2 months after being diagnosed with 
      trimethoprim/sulfamethoxazole-induced DRESS syndrome. Typical DRESS features were 
      absent at onset of these symptoms. Echocardiography demonstrated biventricular 
      systolic dysfunction, and electrocardiography (ECG) showed complete right bundle 
      branch block and diffuse ST-segment elevation. The patient was admitted for 
      high-dose inotropic support; however, his condition deteriorated. Veno-arterial 
      extracorporeal membrane oxygenation (VA-ECMO) and intra-aortic balloon pump were 
      initiated on the third day of admission. Endomyocardial biopsy suggested the 
      diagnosis of DRESS-associated myocarditis and a high-dose corticosteroid was 
      commenced. While he was ECMO-dependent, the patient suffered multiple episodes of 
      ventricular tachycardia on a background of cardioversion-resistant accelerated 
      idioventricular rhythm. After 24 days of ECMO support, the ventricular function 
      improved, and ECG reverted to sinus rhythm. His recovery allowed corticosteroid 
      discontinuation 15 months after hospital discharge. Conclusion: Typical DRESS 
      syndrome features may not accompany the onset of DRESS-associated myocarditis. 
      Mechanical circulatory support and adequate immunosuppression could save patients 
      with malignant arrhythmias and delayed myocardial recovery.
CI  - (c) Touch Medical Media 2020.
FAU - Seree-Aphinan, Chutima
AU  - Seree-Aphinan C
AD  - Department of Internal Medicine, Faculty of Medicine, Prince of Songkla 
      University, Songkhla, Thailand.
FAU - Assanangkornchai, Nawaporn
AU  - Assanangkornchai N
AD  - Department of Internal Medicine, Faculty of Medicine, Prince of Songkla 
      University, Songkhla, Thailand.
FAU - Nilmoje, Thanapon
AU  - Nilmoje T
AD  - Department of Internal Medicine, Faculty of Medicine, Prince of Songkla 
      University, Songkhla, Thailand.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20201211
PL  - England
TA  - Heart Int
JT  - Heart international
JID - 101541778
PMC - PMC9524603
OTO - NOTNLM
OT  - Drug reaction with eosinophilia and systemic symptoms (DRESS)
OT  - drug-induced hypersensitivity syndrome
OT  - extracorporeal membrane oxygenation (ECMO)
OT  - myocarditis
COIS- Disclosures: Chutima Seree-aphinan, Nawaporn Assanangkornchai and Thanapon 
      Nilmoje have no financial or non-financial relationships or activities to declare 
      in relation to this article.
EDAT- 2020/12/11 00:00
MHDA- 2020/12/11 00:01
PMCR- 2020/12/11
CRDT- 2022/10/24 04:17
PHST- 2020/08/11 00:00 [received]
PHST- 2020/11/09 00:00 [accepted]
PHST- 2022/10/24 04:17 [entrez]
PHST- 2020/12/11 00:00 [pubmed]
PHST- 2020/12/11 00:01 [medline]
PHST- 2020/12/11 00:00 [pmc-release]
AID - 10.17925/HI.2020.14.2.112 [doi]
PST - epublish
SO  - Heart Int. 2020 Dec 11;14(2):112-117. doi: 10.17925/HI.2020.14.2.112. eCollection 
      2020.