PMID- 36277883
OWN - NLM
STAT- MEDLINE
DCOM- 20221025
LR  - 20240117
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2022
DP  - 2022
TI  - The Association between the Risk of Esophageal Cancer and Type 2 Diabetes 
      Mellitus: An Updated Meta-Analysis.
PG  - 8129771
LID - 10.1155/2022/8129771 [doi]
LID - 8129771
AB  - BACKGROUND: A large amount of publications had reported the association between 
      incidence of esophageal cancer (EC) and type 2 diabetes mellitus (T2DM) in the 
      past decade. However, those papers' results are inconsistent on relationships 
      between T2DM the incidence of EC. Therefore, the objective of this meta-analysis 
      was to determine the relationship between T2DM and the risk of EC (including 2 
      histological types, esophageal adenocarcinoma [EADC] and esophageal squamous cell 
      carcinoma [ESCC]). METHOD: We finally extracted 19 articles though Pubmed, 
      Embased, and Cochrane library. Those identify extraction date including 14,312 
      cases and 24,959,067 control records and then mixed the relative risks (RRs) and 
      corresponding 95% confidence intervals (95%CIs) through STATA. RESULTS: We 
      observed that there are significantly positive correlation between T2DM and EC 
      risk (RR = 1.28, 95% CI: 1.05-1.57, P = 0.015).Also, our study showed positive 
      correlation between T2DM and EADC (esophageal adenocarcinoma) risk (RR = 1.28, 
      95% CI: 1.05-1.57, P < 0.001). What's more, subgroup analysis based on ethnicity 
      represented the Caucasian is more susceptible to EC (RR = 1.28 ,95% CI: 
      1.10-1.49, P = 0.001). CONCLUSION: Those results offer a recent epidemiological 
      and integrated evidence to ascertain the correlations between T2DM and incidence 
      of EC. Those results take public health implications on preventing T2DM and then 
      depress the occurrence of EC. Our study also provides referenced information for 
      the prevention. However, some data is still insufficient, and more research 
      should be carried out.
CI  - Copyright (c) 2022 Runquan Zhou et al.
FAU - Zhou, Runquan
AU  - Zhou R
AD  - Department Of Thoracic Surgery, The Third Affiliated Hospital of Chongqing 
      Medical University, Chongqing 401120, China.
FAU - Huang, Chenglu
AU  - Huang C
AD  - Department of Thoracic Surgery, Chongqing University Cancer Hospital, No. 181 
      Hanyu Road, Shapingba District, Chongqing 400030, China.
FAU - Luo, Zhilin
AU  - Luo Z
AUID- ORCID: 0000-0003-4352-1984
AD  - Department Of Thoracic Surgery, The Third Affiliated Hospital of Chongqing 
      Medical University, Chongqing 401120, China.
FAU - Wang, Tianhu
AU  - Wang T
AUID- ORCID: 0000-0002-6640-5823
AD  - Department Of Thoracic Surgery, The Third Affiliated Hospital of Chongqing 
      Medical University, Chongqing 401120, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Retracted Publication
DEP - 20221013
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - Adenocarcinoma Of Esophagus
SB  - IM
RIN - Biomed Res Int. 2024 Jan 9;2024:9785681. PMID: 38230191
MH  - Humans
MH  - *Esophageal Neoplasms/epidemiology
MH  - *Diabetes Mellitus, Type 2/complications/epidemiology/prevention & control
MH  - *Esophageal Squamous Cell Carcinoma
MH  - *Adenocarcinoma/epidemiology/complications
MH  - Risk Factors
PMC - PMC9584674
COIS- No conflicts of interest regarding this work.
EDAT- 2022/10/25 06:00
MHDA- 2022/10/26 06:00
PMCR- 2022/10/13
CRDT- 2022/10/24 04:41
PHST- 2022/07/18 00:00 [received]
PHST- 2022/08/15 00:00 [revised]
PHST- 2022/09/20 00:00 [accepted]
PHST- 2022/10/24 04:41 [entrez]
PHST- 2022/10/25 06:00 [pubmed]
PHST- 2022/10/26 06:00 [medline]
PHST- 2022/10/13 00:00 [pmc-release]
AID - 10.1155/2022/8129771 [doi]
PST - epublish
SO  - Biomed Res Int. 2022 Oct 13;2022:8129771. doi: 10.1155/2022/8129771. eCollection 
      2022.