PMID- 36278002 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20221025 IS - 1662-4548 (Print) IS - 1662-453X (Electronic) IS - 1662-453X (Linking) VI - 16 DP - 2022 TI - Retinal nerve fiber layer in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. PG - 964715 LID - 10.3389/fnins.2022.964715 [doi] LID - 964715 AB - PURPOSE: Tauopathy and transactive response DNA binding protein 43 (TDP-43) proteinopathy are associated with neurodegenerative diseases. These proteinopathies are difficult to detect in vivo. This study examined if spectral-domain optical coherence tomography (SD-OCT) can differentiate in vivo the difference in peripapillary retinal nerve fibre layer (pRNFL) thickness and macular retinal thickness between participants with presumed tauopathy (progressive supranuclear palsy) and those with presumed TDP-43 proteinopathy (amyotrophic lateral sclerosis and semantic variant primary progressive aphasia). STUDY DESIGN: Prospective, multi-centre, observational study. MATERIALS AND METHODS: pRNFL and macular SD-OCT images were acquired in both eyes of each participant using Heidelberg Spectralis SD-OCT. Global and pRNFL thickness in 6 sectors were analyzed, as well as macular thickness in a central 1 mm diameter zone and 4 surrounding sectors. Linear mixed model methods adjusting for baseline differences between groups were used to compare the two groups with respect to pRNFL and macular thickness. RESULTS: A significant difference was found in mean pRNFL thickness between groups, with the TDP-43 group (n = 28 eyes) having a significantly thinner pRNFL in the temporal sector than the tauopathy group (n = 9 eyes; mean difference = 15.46 mum, SE = 6.98, p = 0.046), which was not significant after adjusting for multiple comparisons. No other significant differences were found between groups for pRNFL or macular thickness. CONCLUSION: The finding that the temporal pRNFL in the TDP-43 group was on average 15.46 mum thinner could potentially have clinical significance. Future work with larger sample sizes, longitudinal studies, and at the level of retinal sublayers will help to determine the utility of SD-OCT to differentiate between these two proteinopathies. CI - Copyright (c) 2022 Wong, Hudson, Snook, Tayyari, Jung, Binns, Samet, Cheng, Balian, Mandelcorn, Margolin, Finger, Black, Tang-Wai, Zinman, Tan, Lou, Masellis, Abrahao, Frank, Beaton, Sunderland, Arnott, ONDRI Investigators, Tartaglia and Hatch. FAU - Wong, Bryan M AU - Wong BM AD - Faculty of Medicine, University of Toronto, Toronto, ON, Canada. AD - Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, ON, Canada. FAU - Hudson, Christopher AU - Hudson C AD - Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, ON, Canada. AD - School of Optometry and Vision Science, University of Waterloo, Waterloo, ON, Canada. FAU - Snook, Emily AU - Snook E AD - Faculty of Medicine, University of Toronto, Toronto, ON, Canada. FAU - Tayyari, Faryan AU - Tayyari F AD - School of Optometry and Vision Science, University of Waterloo, Waterloo, ON, Canada. AD - Kensington Eye Institute, Toronto, ON, Canada. FAU - Jung, Hyejung AU - Jung H AD - Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada. FAU - Binns, Malcolm A AU - Binns MA AD - Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada. AD - Rotman Research Institute, Baycrest Health Sciences, Toronto, ON, Canada. FAU - Samet, Saba AU - Samet S AD - Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, ON, Canada. FAU - Cheng, Richard W AU - Cheng RW AD - Kensington Eye Institute, Toronto, ON, Canada. FAU - Balian, Carmen AU - Balian C AD - School of Optometry and Vision Science, University of Waterloo, Waterloo, ON, Canada. AD - Kensington Eye Institute, Toronto, ON, Canada. FAU - Mandelcorn, Efrem D AU - Mandelcorn ED AD - Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, ON, Canada. AD - Kensington Eye Institute, Toronto, ON, Canada. FAU - Margolin, Edward AU - Margolin E AD - Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, ON, Canada. AD - Kensington Eye Institute, Toronto, ON, Canada. FAU - Finger, Elizabeth AU - Finger E AD - Department of Clinical Neurological Sciences, Western University, London, ON, Canada. FAU - Black, Sandra E AU - Black SE AD - Department of Medicine (Neurology), Sunnybrook Health Sciences Centre, Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, University of Toronto, Toronto, ON, Canada. AD - Department of Medicine, Division of Neurology, University of Toronto, Toronto, ON, Canada. FAU - Tang-Wai, David F AU - Tang-Wai DF AD - Department of Medicine, Division of Neurology, University of Toronto, Toronto, ON, Canada. AD - Krembil Brain Institute, University Health Network Memory Clinic, Toronto, ON, Canada. FAU - Zinman, Lorne AU - Zinman L AD - Department of Medicine (Neurology), Sunnybrook Health Sciences Centre, Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, University of Toronto, Toronto, ON, Canada. AD - Department of Medicine, Division of Neurology, University of Toronto, Toronto, ON, Canada. FAU - Tan, Brian AU - Tan B AD - Rotman Research Institute, Baycrest Health Sciences, Toronto, ON, Canada. FAU - Lou, Wendy AU - Lou W AD - Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada. FAU - Masellis, Mario AU - Masellis M AD - Department of Medicine (Neurology), Sunnybrook Health Sciences Centre, Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, University of Toronto, Toronto, ON, Canada. AD - Department of Medicine, Division of Neurology, University of Toronto, Toronto, ON, Canada. FAU - Abrahao, Agessandro AU - Abrahao A AD - Department of Medicine (Neurology), Sunnybrook Health Sciences Centre, Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, University of Toronto, Toronto, ON, Canada. AD - Department of Medicine, Division of Neurology, University of Toronto, Toronto, ON, Canada. FAU - Frank, Andrew AU - Frank A AD - Bruyere Research Institute, University of Ottawa, Ottawa, ON, Canada. FAU - Beaton, Derek AU - Beaton D AD - Rotman Research Institute, Baycrest Health Sciences, Toronto, ON, Canada. FAU - Sunderland, Kelly M AU - Sunderland KM AD - Rotman Research Institute, Baycrest Health Sciences, Toronto, ON, Canada. FAU - Arnott, Stephen R AU - Arnott SR AD - Rotman Research Institute, Baycrest Health Sciences, Toronto, ON, Canada. CN - ONDRI Investigators FAU - Tartaglia, Maria Carmela AU - Tartaglia MC AD - Department of Medicine, Division of Neurology, University of Toronto, Toronto, ON, Canada. AD - Krembil Brain Institute, University Health Network Memory Clinic, Toronto, ON, Canada. FAU - Hatch, Wendy V AU - Hatch WV AD - Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, ON, Canada. AD - Kensington Eye Institute, Toronto, ON, Canada. LA - eng PT - Journal Article DEP - 20221006 PL - Switzerland TA - Front Neurosci JT - Frontiers in neuroscience JID - 101478481 PMC - PMC9583385 OTO - NOTNLM OT - TDP-43 proteinopathy OT - amyotrophic lateral sclerosis OT - frontotemporal lobar degeneration OT - optical coherence tomography OT - retinal nerve fibre layer OT - tauopathy COIS- EM received honoraria for speaking engagements from Bayer and Novartis, none of which are relevant to this study. SB was a consultant for Roche and Pfizer. SB obtained funding and has funding pending (through institutions) from GE Healthcare, Eli Lilly, Biogen Idec, Genentech, Optina, Roche, and Novartis. SA was a consultant for Indoc Research Canada (not relevant to this study). The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. FIR - Adamo, Sabrina IR - Adamo S FIR - Arnott, Stephen IR - Arnott S FIR - Bartha, Rob IR - Bartha R FIR - Beaton, Derek IR - Beaton D FIR - Berezuk, Courtney IR - Berezuk C FIR - Black, Alanna IR - Black A FIR - Bonnick, Alisia IR - Bonnick A FIR - Breen, David IR - Breen D FIR - Brien, Don IR - Brien D FIR - Bronskill, Susan IR - Bronskill S FIR - Bulman, Dennis IR - Bulman D FIR - Casaubon, Leanne IR - Casaubon L FIR - Chen, Ying IR - Chen Y FIR - Chum, Marvin IR - Chum M FIR - Coe, Brian IR - Coe B FIR - Cornish, Ben IR - Cornish B FIR - Dewar, Jane Lawrence IR - Dewar JL FIR - Dixon, Roger A IR - Dixon RA FIR - El-Defrawy, Sherif IR - El-Defrawy S FIR - Farhan, Sali Mk IR - Farhan SM FIR - Faria, Frederico IR - Faria F FIR - Fraser, Julia IR - Fraser J FIR - Ghani, Mahdi IR - Ghani M FIR - Greenberg, Barry IR - Greenberg B FIR - Haddad, Hassan IR - Haddad H FIR - Hatch, Wendy IR - Hatch W FIR - Holmes, Melissa IR - Holmes M FIR - Hudson, Chris IR - Hudson C FIR - Kleinstiver, Peter IR - Kleinstiver P FIR - Kwan, Donna IR - Kwan D FIR - Leontieva, Elena IR - Leontieva E FIR - Levine, Brian IR - Levine B FIR - Lou, Wendy IR - Lou W FIR - Mandelcorn, Efrem D IR - Mandelcorn ED FIR - Margolin, Ed IR - Margolin E FIR - Marras, Connie IR - Marras C FIR - McIlroy, Bill IR - McIlroy B FIR - McLaughlin, Paula IR - McLaughlin P FIR - Odasso, Manuel Montero IR - Odasso MM FIR - Munoz, Doug IR - Munoz D FIR - Munoz, David IR - Munoz D FIR - Nanayakkara, Nuwan IR - Nanayakkara N FIR - Orange, J B IR - Orange JB FIR - Ozzoude, Miracle IR - Ozzoude M FIR - Peltsch, Alicia IR - Peltsch A FIR - Raamana, Pradeep IR - Raamana P FIR - Ramirez, Joel IR - Ramirez J FIR - Rashkovan, Natalie IR - Rashkovan N FIR - Roberts, Angela IR - Roberts A FIR - Adamson, Yanina Sarquis IR - Adamson YS FIR - Scott, Christopher IR - Scott C FIR - Strong, Michael IR - Strong M FIR - Strothers, Stephen IR - Strothers S FIR - Sujanthan, Sujeevini IR - Sujanthan S FIR - Sunderland, Kelly M IR - Sunderland KM FIR - Symons, Sean IR - Symons S FIR - Tayyari, Faryan IR - Tayyari F FIR - Theyers, Athena IR - Theyers A FIR - Troyer, Angela IR - Troyer A FIR - Uthirakumaran, Abiramy IR - Uthirakumaran A FIR - Ooteghem, Karen Van IR - Ooteghem KV FIR - Woulfe, John IR - Woulfe J FIR - Zamyadi, Mojdeh IR - Zamyadi M FIR - Zou, Guangyong Gy IR - Zou GG EDAT- 2022/10/25 06:00 MHDA- 2022/10/25 06:01 PMCR- 2022/01/01 CRDT- 2022/10/24 04:43 PHST- 2022/06/08 00:00 [received] PHST- 2022/08/31 00:00 [accepted] PHST- 2022/10/24 04:43 [entrez] PHST- 2022/10/25 06:00 [pubmed] PHST- 2022/10/25 06:01 [medline] PHST- 2022/01/01 00:00 [pmc-release] AID - 10.3389/fnins.2022.964715 [doi] PST - epublish SO - Front Neurosci. 2022 Oct 6;16:964715. doi: 10.3389/fnins.2022.964715. eCollection 2022.