PMID- 36278642
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221028
IS  - 2079-4983 (Print)
IS  - 2079-4983 (Electronic)
IS  - 2079-4983 (Linking)
VI  - 13
IP  - 4
DP  - 2022 Oct 1
TI  - Smart Bacteria-Responsive Drug Delivery Systems in Medical Implants.
LID - 10.3390/jfb13040173 [doi]
LID - 173
AB  - With the rapid development of implantable biomaterials, the rising risk of 
      bacterial infections has drawn widespread concern. Due to the high recurrence 
      rate of bacterial infections and the issue of antibiotic resistance, the common 
      treatments of peri-implant infections cannot meet the demand. In this context, 
      stimuli-responsive biomaterials have attracted attention because of their great 
      potential to spontaneously modulate the drug releasing rate. Numerous smart 
      bacteria-responsive drug delivery systems (DDSs) have, therefore, been designed 
      to temporally and spatially release antibacterial agents from the implants in an 
      autonomous manner at the infected sites. In this review, we summarized recent 
      advances in bacteria-responsive DDSs used for combating bacterial infections, 
      mainly according to the different trigger modes, including physical 
      stimuli-responsive, virulence-factor-responsive, host-immune-response responsive 
      and their combinations. It is believed that the smart bacteria-responsive DDSs 
      will become the next generation of mainstream antibacterial therapies.
FAU - Yang, Yijie
AU  - Yang Y
AUID- ORCID: 0000-0003-0245-2433
AD  - Shanghai Key Laboratory of Stomatology, Department of Oral and Maxillo-Facial 
      Implantology, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiao 
      Tong University, Shanghai 200011, China.
FAU - Jiang, Xue
AU  - Jiang X
AD  - Shanghai Key Laboratory of Stomatology, Department of Oral and Maxillo-Facial 
      Implantology, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiao 
      Tong University, Shanghai 200011, China.
FAU - Lai, Hongchang
AU  - Lai H
AD  - Shanghai Key Laboratory of Stomatology, Department of Oral and Maxillo-Facial 
      Implantology, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiao 
      Tong University, Shanghai 200011, China.
FAU - Zhang, Xiaomeng
AU  - Zhang X
AD  - Shanghai Key Laboratory of Stomatology, Department of Oral and Maxillo-Facial 
      Implantology, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiao 
      Tong University, Shanghai 200011, China.
LA  - eng
GR  - JYJC202205/Cross-disciplinary Research Fund of Shanghai Ninth People's Hospital, 
      Shanghai JiaoTong university School of Medicine/
GR  - 82001098/National Natural Science Foundation of China/
PT  - Journal Article
PT  - Review
DEP - 20221001
PL  - Switzerland
TA  - J Funct Biomater
JT  - Journal of functional biomaterials
JID - 101570734
PMC - PMC9589986
OTO - NOTNLM
OT  - anti-bacterial
OT  - drug release
OT  - implants
OT  - stimuli-responsive
COIS- The authors declare no conflict of interest.
EDAT- 2022/10/25 06:00
MHDA- 2022/10/25 06:01
PMCR- 2022/10/01
CRDT- 2022/10/24 06:34
PHST- 2022/09/05 00:00 [received]
PHST- 2022/09/27 00:00 [revised]
PHST- 2022/09/29 00:00 [accepted]
PHST- 2022/10/24 06:34 [entrez]
PHST- 2022/10/25 06:00 [pubmed]
PHST- 2022/10/25 06:01 [medline]
PHST- 2022/10/01 00:00 [pmc-release]
AID - jfb13040173 [pii]
AID - jfb-13-00173 [pii]
AID - 10.3390/jfb13040173 [doi]
PST - epublish
SO  - J Funct Biomater. 2022 Oct 1;13(4):173. doi: 10.3390/jfb13040173.