PMID- 36279789
OWN - NLM
STAT- MEDLINE
DCOM- 20221108
LR  - 20221108
IS  - 1618-131X (Electronic)
IS  - 1438-4639 (Linking)
VI  - 246
DP  - 2022 Sep
TI  - Exposure to multiple trace elements and thyroid cancer risk in Chinese adults: A 
      case-control study.
PG  - 114049
LID - S1438-4639(22)00132-8 [pii]
LID - 10.1016/j.ijheh.2022.114049 [doi]
AB  - The incidence of thyroid cancer (TC) has increased rapidly in last decades. 
      Multiple trace elements in the external environment have important effects with 
      thyroid function. However, the evidence for these on TC risk were rarely 
      reported. A total of 585 newly diagnosed TC patients and 585 healthy controls 
      were included in this study, and 14 urinary elements were measured to explain the 
      fixed-exposure effect on TC risk. Conditional logistic regressions were used to 
      reflect the multi-element associations, and Bayesian kernel machine regression 
      (BKMR) was applied to show the tendency of mixed effects. Furthermore, the 
      interaction effects were examined by Generalized linear model (GLM). The levels 
      of lithium (Li), cobalt (Co), strontium (Sr), zinc (Zn) and copper (Cu) had 
      negative effects with TC risk, nevertheless lead (Pb), arsenic (As) and chromide 
      (Cr) showed positive effects. The BKMR and GLM models reflected the effect 
      fluctuations of different elements, and there was a slight interaction effects 
      between Li and Cr, Co, Zn and Pb. Further study is required to confirm these 
      results in the future.
CI  - Copyright (c) 2022 Elsevier GmbH. All rights reserved.
FAU - He, Jia-Liu
AU  - He JL
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China; Department of 
      Epidemiology and Health Statistics, Southeast University, 87 Dingjiaqiao Road, 
      Nanjing, Jiangsu, 210009, China.
FAU - Wu, Hua-Bing
AU  - Wu HB
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China.
FAU - Hu, Wen-Lei
AU  - Hu WL
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China.
FAU - Liu, Jian-Jun
AU  - Liu JJ
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China.
FAU - Zhang, Qian
AU  - Zhang Q
AD  - Department of Epidemiology and Health Statistics, School of Public Health, Fujian 
      Medical University, Fuzhou, Fujian, 350122, China.
FAU - Xiao, Wei
AU  - Xiao W
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China.
FAU - Hu, Ming-Jun
AU  - Hu MJ
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China.
FAU - Wu, Ming
AU  - Wu M
AD  - Department of Epidemiology and Health Statistics, Southeast University, 87 
      Dingjiaqiao Road, Nanjing, Jiangsu, 210009, China; Department of Chronic Disease 
      Control, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, 
      China. Electronic address: jswuming@vip.sina.com.
FAU - Huang, Fen
AU  - Huang F
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China. Electronic 
      address: fenh@ahmu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20221021
PL  - Germany
TA  - Int J Hyg Environ Health
JT  - International journal of hygiene and environmental health
JID - 100898843
RN  - 0 (Trace Elements)
RN  - 2P299V784P (Lead)
SB  - IM
MH  - Adult
MH  - Humans
MH  - *Trace Elements
MH  - Case-Control Studies
MH  - Bayes Theorem
MH  - Lead
MH  - *Thyroid Neoplasms/epidemiology
MH  - China/epidemiology
OTO - NOTNLM
OT  - Case-control study
OT  - Environmental exposure
OT  - Thyroid cancer
OT  - Trace elements
COIS- Declaration of competing interest The authors declared that they have no conflict 
      of interest.
EDAT- 2022/10/25 06:00
MHDA- 2022/11/09 06:00
CRDT- 2022/10/24 18:29
PHST- 2022/07/08 00:00 [received]
PHST- 2022/09/08 00:00 [revised]
PHST- 2022/10/04 00:00 [accepted]
PHST- 2022/10/25 06:00 [pubmed]
PHST- 2022/11/09 06:00 [medline]
PHST- 2022/10/24 18:29 [entrez]
AID - S1438-4639(22)00132-8 [pii]
AID - 10.1016/j.ijheh.2022.114049 [doi]
PST - ppublish
SO  - Int J Hyg Environ Health. 2022 Sep;246:114049. doi: 10.1016/j.ijheh.2022.114049. 
      Epub 2022 Oct 21.