PMID- 36281415
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221026
IS  - 2405-8440 (Print)
IS  - 2405-8440 (Electronic)
IS  - 2405-8440 (Linking)
VI  - 8
IP  - 10
DP  - 2022 Oct
TI  - Acute effects of low load resistance training with blood flow restriction on 
      serum growth hormone, insulin-like growth factor-1, and testosterone in patients 
      with mild to moderate unilateral knee osteoarthritis.
PG  - e11051
LID - 10.1016/j.heliyon.2022.e11051 [doi]
LID - e11051
AB  - OBJECTIVE: To investigate the acute effects of blood flow restriction (BFR) with 
      single-leg low load resistance exercise and high load resistance exercise on 
      serum insulin-like growth factor-1 (IGF-1), growth hormone (GH), and testosterone 
      in patients with unilateral knee osteoarthritis (OA). METHODS: This study 
      recruited 18 postmenopausal female patients with mild to moderate unilateral knee 
      OA, which was then followed by randomly conducting three resistance exercise 
      protocols by drawing lots: 1. A 30% 1-repetition maximum (1-RM) resistance 
      exercise with BFR of 70% arterial occlusive pressure (AOP) (BFR group); 2. A 70% 
      1-RM resistance exercise without BFR (RES group); 3. A 30% 1-RM resistance 
      exercise without BFR (CON group). Blood lactate (BLA) and muscle growth related 
      hormone levels were tested at 4-time points: before exercise, immediately after 
      exercise, 15 min after exercise, and 30 min after exercise. RESULTS: There was no 
      statistical difference between the indexes in each group before exercise, but the 
      different exercise had different effects on each index and also an interactive 
      effect (P < 0.05). The increase of rating of perceived exertion in the BFR and 
      RES groups, which were of similar magnitude, was greater compared to the levels 
      in the CON group (P < 0.05). Post-exercise BLA levels were lower in the CON group 
      in comparison to the BFR and RES groups (P < 0.05). Rather than the RES group, GH 
      levels of the BFR group were also significantly higher than the CON group (P < 
      0.05) at 15 min post-exercise. At post- and 15 min after exercise, the CON group 
      recorded significantly lower IGF-1 levels compared to the BFR and RES groups (P < 
      0.05). At post- and 15 min after exercise, the CON group (P < 0.05) reflected the 
      lowest testosterone levels, followed by the RES group (P < 0.05), and the highest 
      in the BFR group (P < 0.05). CONCLUSIONS: Myogenesis-related hormones in women 
      with unilateral knee OA could be increased by high load resistance exercise and 
      low load resistance exercise with BFR on unaffected limb.
CI  - (c) 2022 The Authors.
FAU - Chen, Yangguang
AU  - Chen Y
AD  - College of Physical Education, Zhengzhou Shengda University, Zhengzhou, Henan, 
      China.
FAU - Wang, Junguo
AU  - Wang J
AD  - Center for Osteoarticular and Trauma Surgery, Qingdao Hospital of Traditional 
      Chinese Medicine (Qingdao Hiser Hospital), Qingdao, Shandong, China.
FAU - Li, Shuoqi
AU  - Li S
AD  - College of Physical Education, Yangzhou University, Yangzhou, Zhejiang, China.
FAU - Li, Yinghao
AU  - Li Y
AD  - College of Physical Education, Zhengzhou Shengda University, Zhengzhou, Henan, 
      China.
LA  - eng
PT  - Journal Article
DEP - 20221014
PL  - England
TA  - Heliyon
JT  - Heliyon
JID - 101672560
PMC - PMC9586906
OTO - NOTNLM
OT  - Blood flow restriction exercise
OT  - Knee osteoarthritis
OT  - Myogenic hormones
COIS- The authors declare no conflict of interest.
EDAT- 2022/10/26 06:00
MHDA- 2022/10/26 06:01
PMCR- 2022/10/14
CRDT- 2022/10/25 01:48
PHST- 2022/05/13 00:00 [received]
PHST- 2022/09/05 00:00 [revised]
PHST- 2022/10/07 00:00 [accepted]
PHST- 2022/10/25 01:48 [entrez]
PHST- 2022/10/26 06:00 [pubmed]
PHST- 2022/10/26 06:01 [medline]
PHST- 2022/10/14 00:00 [pmc-release]
AID - S2405-8440(22)02339-8 [pii]
AID - e11051 [pii]
AID - 10.1016/j.heliyon.2022.e11051 [doi]
PST - epublish
SO  - Heliyon. 2022 Oct 14;8(10):e11051. doi: 10.1016/j.heliyon.2022.e11051. 
      eCollection 2022 Oct.