PMID- 36283558
OWN - NLM
STAT- MEDLINE
DCOM- 20221221
LR  - 20221222
IS  - 1879-0003 (Electronic)
IS  - 0141-8130 (Linking)
VI  - 224
DP  - 2023 Jan 1
TI  - Impact of Lycium barbarum polysaccharide on the expression of glucagon-like 
      peptide 1 in vitro and in vivo.
PG  - 908-918
LID - S0141-8130(22)02418-7 [pii]
LID - 10.1016/j.ijbiomac.2022.10.176 [doi]
AB  - Several studies showed the efficacy of Lycium barbarum polysaccharide (LBP) in 
      diabetic animals and patients with type 2 diabetes mellitus (T2DM). However, the 
      mechanism of LBP in alleviating T2DM based on glucagon-like peptide 1 (GLP1) has 
      not been suitably elucidated. GLP1 is an important peptide that plays a role in 
      blood glucose homeostasis. Inhibition of sodium/glucose cotransporter 1 (SGLT1) 
      can result in a net increase in GLP1 release. We found that LBP could reduce 
      SGLT1 expression. Thus, the effects of LBP on the first- and second-phase 
      secretion of GLP1 were systematically assessed in vitro using STC1 cells and in 
      vivo using diabetic KK(Ay) mice. LBP could induce the first-phase secretion of 
      GLP1 by stimulating calcium ion influx in vitro and by inhibiting 
      alpha-glucosidase activity in vivo. Regulation of Gcg gene expression by 
      modulating the Wnt/beta-catenin and cAMP/Epac pathways, as well as inhibition of 
      alpha-glucosidase activity, was responsible for the second-phase secretion of 
      GLP1. LBP could stimulate GLP1 secretion; however, dipeptidyl peptidase 4 (DPP4) 
      activated by LBP might offset the second-phase secretion of GLP1. Thus, we 
      suggest considering the simultaneous use of LBP and a DPP4 inhibitor to stimulate 
      slow, continuous GLP1 secretion. Further studies are warranted for in-depth 
      mechanistic information.
CI  - Copyright (c) 2022. Published by Elsevier B.V.
FAU - Zhao, Cong
AU  - Zhao C
AD  - School of Public Health and Management, Ningxia Medical University, Yinchuan 
      750004, China.
FAU - Zhao, He
AU  - Zhao H
AD  - School of Public Health and Management, Ningxia Medical University, Yinchuan 
      750004, China.
FAU - Zhang, Chun-Cheng
AU  - Zhang CC
AD  - School of Public Health and Management, Ningxia Medical University, Yinchuan 
      750004, China.
FAU - Yang, Xiao-Hui
AU  - Yang XH
AD  - School of Public Health and Management, Ningxia Medical University, Yinchuan 
      750004, China.
FAU - Chen, Kang
AU  - Chen K
AD  - School of Public Health and Management, Ningxia Medical University, Yinchuan 
      750004, China.
FAU - Xue, Yang
AU  - Xue Y
AD  - School of Public Health and Management, Ningxia Medical University, Yinchuan 
      750004, China.
FAU - Li, Qian
AU  - Li Q
AD  - School of Public Health and Management, Ningxia Medical University, Yinchuan 
      750004, China.
FAU - Deng, Shu-Ying
AU  - Deng SY
AD  - Disease Prevention and Control Center in Xiang Yang, Hubei 441000, China. 
      Electronic address: dengshuying1995@126.com.
FAU - Cai, Hui-Zhen
AU  - Cai HZ
AD  - School of Public Health and Management, Ningxia Medical University, Yinchuan 
      750004, China; Ningxia Key Laboratory of Environmental Factors and Chronic 
      Disease Control, Yinchuan 750004, China. Electronic address: 18169010183@163.com.
LA  - eng
PT  - Journal Article
DEP - 20221022
PL  - Netherlands
TA  - Int J Biol Macromol
JT  - International journal of biological macromolecules
JID - 7909578
RN  - 89750-14-1 (Glucagon-Like Peptide 1)
RN  - 0 (lycium barbarum polysaccharide)
RN  - EC 3.2.1.20 (alpha-Glucosidases)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Drugs, Chinese Herbal)
SB  - IM
MH  - Mice
MH  - Animals
MH  - Glucagon-Like Peptide 1/metabolism
MH  - *Diabetes Mellitus, Type 2/metabolism
MH  - alpha-Glucosidases
MH  - Hypoglycemic Agents/pharmacology
MH  - *Drugs, Chinese Herbal
MH  - *Lycium/metabolism
OTO - NOTNLM
OT  - Glucagon-like peptide 1
OT  - Incretin effect
OT  - Lycium barbarum polysaccharide
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2022/10/26 06:00
MHDA- 2022/12/22 06:00
CRDT- 2022/10/25 19:25
PHST- 2022/06/21 00:00 [received]
PHST- 2022/10/12 00:00 [revised]
PHST- 2022/10/20 00:00 [accepted]
PHST- 2022/10/26 06:00 [pubmed]
PHST- 2022/12/22 06:00 [medline]
PHST- 2022/10/25 19:25 [entrez]
AID - S0141-8130(22)02418-7 [pii]
AID - 10.1016/j.ijbiomac.2022.10.176 [doi]
PST - ppublish
SO  - Int J Biol Macromol. 2023 Jan 1;224:908-918. doi: 10.1016/j.ijbiomac.2022.10.176. 
      Epub 2022 Oct 22.