PMID- 36283602
OWN - NLM
STAT- MEDLINE
DCOM- 20221129
LR  - 20221129
IS  - 1879-0038 (Electronic)
IS  - 0378-1119 (Linking)
VI  - 851
DP  - 2023 Jan 30
TI  - Association of tag single nucleotide polymorphisms (SNPs) at lncRNA MALAT1 with 
      type 2 diabetes mellitus susceptibility in the Chinese Han population: A 
      case-control study.
PG  - 147008
LID - S0378-1119(22)00828-9 [pii]
LID - 10.1016/j.gene.2022.147008 [doi]
AB  - BACKGROUND: Type 2 diabetes mellitus (T2DM) is a chronic, lifelong disease. The 
      molecular mechanisms and pathophysiology of T2DM have not yet been fully 
      elucidated. Dysregulation of the long non-coding RNA metastasis associated lung 
      adenocarcinoma transcript 1 (lncRNA MALAT1) is considered one of the main 
      contributing factors of the dysfunction found in many diseases, including those 
      of the endocrine system. The aim of this study was to investigate the association 
      between lncRNA MALAT1 single nucleotide polymorphisms (SNPs) and T2DM in the 
      Chinese Han population. METHODS: We genotyped three SNPs (rs3200401 C > T, 
      rs619586 A > G, rs11227209 C > G) of the MALAT1 gene, including 571 T2DM patients 
      and 526 controls. The association between different genotypes and the risk of 
      T2DM was analyzed using logistic regression, and the results were expressed by 
      odds ratio (OR) and its 95% confidence interval (95%CI), and then stratified by 
      age, sex, and BMI. P < 0.05 on both sides was considered as statistically 
      significant. RESULTS: We found that the CT + TT genotypes of the rs3200401 
      polymorphism were significantly associated with an increased risk of T2DM in 
      Chinese Han population (OR = 1.77; 95% CI:1.35-2.33; P(adjusted) < 0.001), 
      whereas MALAT1 rs619586 AG + GG genotypes were associated with a reduced risk of 
      T2DM (OR = 0.67; 95% CI:0.48-0.94; P(adjusted) = 0.021). Subsequent stratified 
      analysis showed that compared with the rs3200401 CC genotype, CT + TT genotypes 
      were associated with an increased risk of T2DM in the male, female, 
      age >/= 65 years, and BMI >/= 24 subgroups (OR = 1.68, 95% CI:1.10-2.56, 
      P(adjusted) = 0.016; OR = 1.83, 95% CI:1.27-2.62, P(adjusted) = 0.001; OR = 1.86, 
      95% CI:1.38-2.52, P(adjusted) < 0.001; OR = 2.13, 95% CI:1.45-3.15, 
      P(adjusted) < 0.001; respectively). Haplotype analysis showed that T-A-C 
      haplotype had a 1.533-fold increased risk of T2DM (95% CI, 1.208-1.945, 
      P < 0.001) and C-G-G was associated with a decreased risk of T2DM. No significant 
      association was found between rs11227209 and T2DM risk (P > 0.05). CONCLUSION: 
      The results suggest that MALAT1 rs619586 and rs3200401 confer susceptibility for 
      T2DM in the Chinese Han population and provide new genetic targets for the 
      treatment of diabetes and its complications in the future.
CI  - Copyright (c) 2022 Elsevier B.V. All rights reserved.
FAU - Chang, Wei-Wei
AU  - Chang WW
AD  - Department of Epidemiology and Health Statistics, School of Public Health, Wannan 
      Medical College, Wuhu 241002, Anhui, China.
FAU - Zhang, Liu
AU  - Zhang L
AD  - Department of Hospital Infection Management Office, Wuhu Hospital of Traditional 
      Chinese Medicine, Wuhu 241000, Anhui, China.
FAU - Wen, Li-Ying
AU  - Wen LY
AD  - Department of Epidemiology and Health Statistics, School of Public Health, Wannan 
      Medical College, Wuhu 241002, Anhui, China.
FAU - Huang, Qian
AU  - Huang Q
AD  - School of Health Management, Anhui Medical University, Hefei 230032, Anhui, 
      China.
FAU - Tong, Xin
AU  - Tong X
AD  - Department of Epidemiology and Health Statistics, School of Public Health, Wannan 
      Medical College, Wuhu 241002, Anhui, China.
FAU - Tao, Yu-Jing
AU  - Tao YJ
AD  - Department of Epidemiology and Health Statistics, School of Public Health, Wannan 
      Medical College, Wuhu 241002, Anhui, China.
FAU - Chen, Gui-Mei
AU  - Chen GM
AD  - School of Health Management, Anhui Medical University, Hefei 230032, Anhui, 
      China. Electronic address: chengm@ahmu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20221023
PL  - Netherlands
TA  - Gene
JT  - Gene
JID - 7706761
RN  - 0 (RNA, Long Noncoding)
SB  - IM
MH  - Humans
MH  - Male
MH  - Female
MH  - Aged
MH  - Polymorphism, Single Nucleotide
MH  - *RNA, Long Noncoding/genetics
MH  - Case-Control Studies
MH  - Genetic Predisposition to Disease
MH  - *Diabetes Mellitus, Type 2/genetics
MH  - China
OTO - NOTNLM
OT  - Diabetes mellitus
OT  - MALAT1
OT  - Polymorphism
OT  - long non-coding RNA
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2022/10/26 06:00
MHDA- 2022/11/30 06:00
CRDT- 2022/10/25 19:26
PHST- 2022/07/28 00:00 [received]
PHST- 2022/10/10 00:00 [revised]
PHST- 2022/10/19 00:00 [accepted]
PHST- 2022/10/26 06:00 [pubmed]
PHST- 2022/11/30 06:00 [medline]
PHST- 2022/10/25 19:26 [entrez]
AID - S0378-1119(22)00828-9 [pii]
AID - 10.1016/j.gene.2022.147008 [doi]
PST - ppublish
SO  - Gene. 2023 Jan 30;851:147008. doi: 10.1016/j.gene.2022.147008. Epub 2022 Oct 23.