PMID- 36284455
OWN - NLM
STAT- MEDLINE
DCOM- 20230110
LR  - 20230209
IS  - 1096-9071 (Electronic)
IS  - 0146-6615 (Linking)
VI  - 95
IP  - 1
DP  - 2023 Jan
TI  - LANA regulates miR-155/GATA3 signaling axis by enhancing c-Jun/c-Fos interaction 
      to promote the proliferation and migration of KSHV-infected cells.
PG  - e28255
LID - 10.1002/jmv.28255 [doi]
AB  - Kaposi's sarcoma (KS) is the second most common tumor in people infected with 
      human immunodeficiency virus worldwide, but its pathogenesis is still unclear. In 
      this study, we discovered that the expression of GATA-binding protein 3 (GATA3) 
      was lowly expressed in KS tissues and KSHV-infected cells, while microRNA-155 
      (miR-155) was highly expressed in KS serum and KSHV-infected cells. miR-155 
      promoted the proliferation, migration and invasion of KSHV infection by targeting 
      GATA3. Further, The KSHV-encoded protein, the Latency associated nuclear antigen 
      (LANA), promotes the proliferation, migration and invasion of KSHV-infected cells 
      by regulating the miR-155/GATA3 axis. Regarding the molecular mechanism, c-Jun 
      and c-Fos interact to form a complex. LANA upregulates the expression of c-Jun 
      and c-Fos and enhances the formation of c-Jun/c-Fos complex. The complex binds to 
      the -95 approximately -100 bp site of miR-155 promoter and transcriptionally activates miR-155. 
      All in all, LANA enhances the c-Jun/c-Fos interaction, resulting in enhanced 
      transcriptional regulation of miR-155 by the c-Jun/c-Fos complex, thereby 
      downregulating GATA3 and promoting the proliferation, migration and invasion of 
      KSHV-infected cells. The discovery of LANA/c-Jun/c-Fos/miR-155/GATA3 further 
      refines the pathogenesis of KS, potentially opening a new avenue for developing 
      effective drugs against KS.
CI  - (c) 2022 Wiley Periodicals LLC.
FAU - Luo, Ting
AU  - Luo T
AD  - Precision Clinical Laboratory, Central People's Hospital of Zhanjiang, Zhanjiang, 
      Guangdong, China.
AD  - Key Laboratory of Xinjiang Endemic and Ethnic Disease, School of Medicine, 
      Shihezi University, Shihezi, Xinjiang, China.
FAU - Pan, Yangyang
AU  - Pan Y
AD  - Precision Clinical Laboratory, Central People's Hospital of Zhanjiang, Zhanjiang, 
      Guangdong, China.
AD  - Key Laboratory of Xinjiang Endemic and Ethnic Disease, School of Medicine, 
      Shihezi University, Shihezi, Xinjiang, China.
FAU - Liu, Yuhao
AU  - Liu Y
AD  - Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, 
      Beijing, China.
FAU - Zheng, Jun
AU  - Zheng J
AD  - Key Laboratory of Xinjiang Endemic and Ethnic Disease, School of Medicine, 
      Shihezi University, Shihezi, Xinjiang, China.
FAU - Zhuang, Zhaowei
AU  - Zhuang Z
AD  - Key Laboratory of Xinjiang Endemic and Ethnic Disease, School of Medicine, 
      Shihezi University, Shihezi, Xinjiang, China.
FAU - Ren, Zuodong
AU  - Ren Z
AD  - Key Laboratory of Xinjiang Endemic and Ethnic Disease, School of Medicine, 
      Shihezi University, Shihezi, Xinjiang, China.
FAU - Zhu, Jiaojiao
AU  - Zhu J
AD  - Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, 
      Beijing, China.
FAU - Gu, Yongqing
AU  - Gu Y
AD  - Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, 
      Beijing, China.
FAU - Zeng, Yan
AU  - Zeng Y
AUID- ORCID: 0000-0002-9823-1266
AD  - Precision Clinical Laboratory, Central People's Hospital of Zhanjiang, Zhanjiang, 
      Guangdong, China.
AD  - Key Laboratory of Xinjiang Endemic and Ethnic Disease, School of Medicine, 
      Shihezi University, Shihezi, Xinjiang, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20221103
PL  - United States
TA  - J Med Virol
JT  - Journal of medical virology
JID - 7705876
RN  - 0 (Antigens, Viral)
RN  - 0 (Antigens, Nuclear)
RN  - 0 (MicroRNAs)
RN  - 0 (GATA3 protein, human)
RN  - 0 (GATA3 Transcription Factor)
RN  - 0 (MIRN155 microRNA, human)
SB  - IM
MH  - Humans
MH  - *Herpesvirus 8, Human/physiology
MH  - Cell Line
MH  - *Sarcoma, Kaposi
MH  - Antigens, Viral/metabolism
MH  - Antigens, Nuclear/metabolism
MH  - *MicroRNAs/genetics/metabolism
MH  - Cell Proliferation
MH  - GATA3 Transcription Factor/genetics/metabolism
OTO - NOTNLM
OT  - GATA3
OT  - Kaposi's sarcoma
OT  - LANA
OT  - miR-155
OT  - migration
OT  - proliferation
EDAT- 2022/10/27 06:00
MHDA- 2023/01/11 06:00
CRDT- 2022/10/26 01:12
PHST- 2022/10/08 00:00 [revised]
PHST- 2022/07/19 00:00 [received]
PHST- 2022/10/21 00:00 [accepted]
PHST- 2022/10/27 06:00 [pubmed]
PHST- 2023/01/11 06:00 [medline]
PHST- 2022/10/26 01:12 [entrez]
AID - 10.1002/jmv.28255 [doi]
PST - ppublish
SO  - J Med Virol. 2023 Jan;95(1):e28255. doi: 10.1002/jmv.28255. Epub 2022 Nov 3.