PMID- 36285160 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20230818 IS - 1741-427X (Print) IS - 1741-4288 (Electronic) IS - 1741-427X (Linking) VI - 2022 DP - 2022 TI - Noncoding RNAs and Virus and Treatment in Allergic Rhinitis. PG - 1979447 LID - 10.1155/2022/1979447 [doi] LID - 1979447 AB - Allergic rhinitis (AR) is a type I hypersensitivity reaction disease caused by inhaled allergens and immunoglobulin E (IgE)-mediated. Noncoding RNA (ncRNA) is an important regulator involved in gene expression and can be detected in the cytoplasm or extracellular fluid, which mainly includes microRNAs (miRNA, length 22-24 nucleotides), long noncoding RNAs (lncRNA, length >200 nucleotides), and circRNAs. LncRNA and miRNA both participate in the regulation of immune function. Some respiratory viral infections can aggravate allergic rhinitis, such as a respiratory syncytial virus (RSV) and human metapneumovirus (hMPV). However, the interaction between viral infection and allergy is complex and the mechanism is still unclear. In this review, we summarized the interactions of noncoding RNAs and viruses in the occurrence and development of AR, along with the treatments focusing on the noncoding RNAs in the past five years. CI - Copyright (c) 2022 Zhu Lei et al. FAU - Lei, Zhu AU - Lei Z AD - Otolaryngology Department, Xianning First People's Hospital, Xianning 437100, Hubei, China. FAU - Feng, Guangrui AU - Feng G AD - Cardiovascular Medicine Department, The First Affiliated Hospital of Hubei University of Science and Technology, Xianning 437100, Hubei, China. FAU - Wang, Zhiguo AU - Wang Z AD - Dermatology Department, The First Affiliated Hospital of Hubei University of Science and Technology, Xianning 437100, Hubei, China. FAU - Ning, Zhifeng AU - Ning Z AUID- ORCID: 0000-0001-9869-5928 AD - Human Anatomy Department, Basic Medicine College, Hubei University of Science and Technology, Xianning 437100, Hubei, China. LA - eng PT - Journal Article PT - Retracted Publication DEP - 20221015 PL - United States TA - Evid Based Complement Alternat Med JT - Evidence-based complementary and alternative medicine : eCAM JID - 101215021 RIN - Evid Based Complement Alternat Med. 2023 Aug 9;2023:9898150. PMID: 37593036 PMC - PMC9588333 COIS- The authors declare that they have no conflicts of interest. EDAT- 2022/10/27 06:00 MHDA- 2022/10/27 06:01 PMCR- 2022/10/15 CRDT- 2022/10/26 02:13 PHST- 2022/07/01 00:00 [received] PHST- 2022/07/31 00:00 [revised] PHST- 2022/08/17 00:00 [accepted] PHST- 2022/10/26 02:13 [entrez] PHST- 2022/10/27 06:00 [pubmed] PHST- 2022/10/27 06:01 [medline] PHST- 2022/10/15 00:00 [pmc-release] AID - 10.1155/2022/1979447 [doi] PST - epublish SO - Evid Based Complement Alternat Med. 2022 Oct 15;2022:1979447. doi: 10.1155/2022/1979447. eCollection 2022.