PMID- 36285916
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221029
IS  - 2076-328X (Print)
IS  - 2076-328X (Electronic)
IS  - 2076-328X (Linking)
VI  - 12
IP  - 10
DP  - 2022 Sep 20
TI  - Epigenetic Effects in HPA Axis Genes Associated with Cortical Thickness, ERP 
      Components and SUD Outcome.
LID - 10.3390/bs12100347 [doi]
LID - 347
AB  - Association between familial loading for alcohol use disorders (AUD) and 
      event-related potentials (ERPs) suggests a genetic basis for these oscillations 
      though much less is known about epigenetic pathways influenced by environmental 
      variation. Early life adversity (ELA) influences negative outcomes much later in 
      life. The stress-activated neuropeptide corticotropin-releasing hormone (CRH) 
      contributes to the deleterious effects of ELA on brain structure and function in 
      animals. Accordingly, we hypothesized that ELA would be related to cortical 
      thickness and electrophysiological characteristics through an epigenetic effect 
      on CRH receptor type-1 (CRHR1) methylation. A total of 217 adolescent and young 
      adult participants from either multiplex alcohol dependence or control families 
      were scanned using magnetic resonance imaging (MRI) at 3T and cortical thickness 
      was determined. Longitudinal follow-up across childhood, adolescence, and young 
      adulthood provided developmental ERP data and measures of adversity. Blood 
      samples for genetic and epigenetic analyses were obtained in childhood. Cortical 
      thickness and visual ERP components were analyzed for their association and 
      tested for familial risk group differences. Visual P300 amplitude at Pz and 
      cortical thickness of the left lateral orbitofrontal region (LOFC), were 
      significantly related to risk group status. LOFC cortical thickness showed a 
      negative correlation with CRHR1 methylation status and with childhood total 
      stress scores from the Life Stressors and Social Resources Inventory (LISRES). 
      Stress scores were also significantly related to P300 amplitude recorded in 
      childhood. The present results suggest that early life adversity reflected in 
      greater total LISRES stress scores in childhood can impact the methylation of the 
      CRHR1 gene with implications for brain development as seen in cortical thickness 
      and electrophysiological signals emanating from particular brain regions.
FAU - Hill, Shirley Y
AU  - Hill SY
AD  - Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 
      O'Hara St., Pittsburgh, PA 15213, USA.
FAU - Wellman, Jeannette L
AU  - Wellman JL
AD  - Department of Psychiatry and Magee Women's Hospital, University of Pittsburgh 
      Medical Center, Pittsburgh, PA 15213, USA.
FAU - Zezza, Nicholas
AU  - Zezza N
AD  - Department of Psychiatry and Shadyside Hospital, University of Pittsburgh Medical 
      Center, Pittsburgh, PA 15213, USA.
FAU - Steinhauer, Stuart R
AU  - Steinhauer SR
AD  - Pittsburgh VA Medical Center, University Drive C, Pittsburgh, PA 15240, USA.
FAU - Sharma, Vinod
AU  - Sharma V
AD  - Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 
      O'Hara St., Pittsburgh, PA 15213, USA.
FAU - Holmes, Brian
AU  - Holmes B
AD  - UPMC Children's Hospital of Pittsburgh, 4401 Penn Ave., Pittsburgh, PA 15224, 
      USA.
LA  - eng
GR  - AA018289, AA05909, AA08082, AA015168, QQ021746/NH/NIH HHS/United States
PT  - Journal Article
DEP - 20220920
PL  - Switzerland
TA  - Behav Sci (Basel)
JT  - Behavioral sciences (Basel, Switzerland)
JID - 101576826
PMC - PMC9598712
OTO - NOTNLM
OT  - CRHR1
OT  - alcohol use disorder (AUD)
OT  - cortical thickness
OT  - early life adversity (ELA)
OT  - epigenetic
OT  - event-related potential (ERP)
OT  - methylation
OT  - stress
COIS- The authors declare no conflict of interest.
EDAT- 2022/10/27 06:00
MHDA- 2022/10/27 06:01
PMCR- 2022/09/20
CRDT- 2022/10/26 07:12
PHST- 2022/08/02 00:00 [received]
PHST- 2022/08/29 00:00 [revised]
PHST- 2022/09/01 00:00 [accepted]
PHST- 2022/10/26 07:12 [entrez]
PHST- 2022/10/27 06:00 [pubmed]
PHST- 2022/10/27 06:01 [medline]
PHST- 2022/09/20 00:00 [pmc-release]
AID - bs12100347 [pii]
AID - behavsci-12-00347 [pii]
AID - 10.3390/bs12100347 [doi]
PST - epublish
SO  - Behav Sci (Basel). 2022 Sep 20;12(10):347. doi: 10.3390/bs12100347.