PMID- 36286265
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221029
IS  - 2308-3425 (Electronic)
IS  - 2308-3425 (Linking)
VI  - 9
IP  - 10
DP  - 2022 Sep 20
TI  - Effect of C1q/TNF-Related Protein 9 on Coronary Artery Calcification: An 
      Observational Study.
LID - 10.3390/jcdd9100313 [doi]
LID - 313
AB  - Coronary artery calcification (CAC) increases the risk of acute coronary 
      syndrome. This study examined the correlation between C1q/TNF-related protein 9 
      (CTRP9) and CAC and explored CTRP9 as a biomarker for prognosis. We divided 275 
      patients with coronary heart disease into four groups. In order to balance the 
      baseline confounding factors, propensity score matching (PSM) was performed to 
      match CAC patients with non-CAC patients in a 1:1 ratio. Optical coherence 
      tomography (OCT) calcification scoring was performed in 126 patients with CAC. 
      Moreover, 140 patients who underwent OCT were followed-up for 9 months for 
      analysis of the correlation between CTRP9 levels and clinical prognosis. Based on 
      OCT calcification scores, 126 patients with CAC were divided into the 0-2 and 3-4 
      groups. Plasma CTRP9 levels were significantly lower in the type 2 diabetes 
      mellitus (T2DM), CAC and CAC with T2DM groups than in the control group. CTRP9 
      played roles as a protective factor and potential predictor in CAC severity. The 
      AUC of the OCT calcification score 3-4 group predicted by the plasma CTRP9 level 
      was 0.766. During the follow-up period, the cumulative event-free survival rate 
      was significantly lower in the low-level CTRP9 (L-CTRP9) group than in the 
      high-level (H-CTRP9) group, and the incidence of major endpoint events was 
      significantly higher in the L-CTRP9 group than in the H-CTRP9 group. CTRP9 can be 
      a valuable biomarker for CAC occurrence and severity and can predict patients' 
      clinical prognosis.
FAU - Liu, Demin
AU  - Liu D
AUID- ORCID: 0000-0002-8784-1026
AD  - Department of Cardiology, The Second Hospital of Hebei Medical University, Heping 
      West Road No. 215, Shijiazhuang 050000, China.
FAU - Ma, Yanan
AU  - Ma Y
AD  - Department of Cardiology, The Second Hospital of Hebei Medical University, Heping 
      West Road No. 215, Shijiazhuang 050000, China.
FAU - Jin, Xiaoxue
AU  - Jin X
AD  - Department of Cardiology, The Second Hospital of Hebei Medical University, Heping 
      West Road No. 215, Shijiazhuang 050000, China.
FAU - Lu, Rui
AU  - Lu R
AD  - Department of Cardiology, The Second Hospital of Hebei Medical University, Heping 
      West Road No. 215, Shijiazhuang 050000, China.
FAU - Hu, Haijuan
AU  - Hu H
AD  - Department of Cardiology, The Second Hospital of Hebei Medical University, Heping 
      West Road No. 215, Shijiazhuang 050000, China.
FAU - Gu, Guoqiang
AU  - Gu G
AD  - Department of Cardiology, The Second Hospital of Hebei Medical University, Heping 
      West Road No. 215, Shijiazhuang 050000, China.
LA  - eng
GR  - 82100301/National Natural Science Foundation of China/
GR  - H2021206220 and H2020206409/Natural Science Foundation of Hebei Province/
PT  - Journal Article
DEP - 20220920
PL  - Switzerland
TA  - J Cardiovasc Dev Dis
JT  - Journal of cardiovascular development and disease
JID - 101651414
PMC - PMC9604104
OTO - NOTNLM
OT  - CTRP9
OT  - coronary artery calcification
OT  - intravascular optical coherence
OT  - type 2 diabetes mellitus
COIS- The authors declare no conflict of interest.
EDAT- 2022/10/27 06:00
MHDA- 2022/10/27 06:01
PMCR- 2022/09/20
CRDT- 2022/10/26 08:23
PHST- 2022/08/09 00:00 [received]
PHST- 2022/09/13 00:00 [revised]
PHST- 2022/09/17 00:00 [accepted]
PHST- 2022/10/26 08:23 [entrez]
PHST- 2022/10/27 06:00 [pubmed]
PHST- 2022/10/27 06:01 [medline]
PHST- 2022/09/20 00:00 [pmc-release]
AID - jcdd9100313 [pii]
AID - jcdd-09-00313 [pii]
AID - 10.3390/jcdd9100313 [doi]
PST - epublish
SO  - J Cardiovasc Dev Dis. 2022 Sep 20;9(10):313. doi: 10.3390/jcdd9100313.