PMID- 36286579
OWN - NLM
STAT- MEDLINE
DCOM- 20221028
LR  - 20231002
IS  - 1557-7449 (Electronic)
IS  - 1087-2914 (Print)
IS  - 1087-2914 (Linking)
VI  - 36
IP  - 10
DP  - 2022 Oct
TI  - Acceptability of Implants for HIV Treatment in Young Children: Perspectives of 
      Health Care Providers in Johannesburg, South Africa.
PG  - 389-395
LID - 10.1089/apc.2022.0087 [doi]
AB  - In South Africa, less than half of children receiving antiretroviral therapy are 
      virally suppressed. Adherence challenges include poor palatability of drugs and 
      high pill burden. Subcutaneous implants offer a long-acting alternative to daily 
      oral dosing regimens, which may improve outcomes in children living with HIV 
      (CLWH). Qualitative in-depth interviews were conducted with 24 health care 
      providers (HCPs) in Johannesburg, South Africa. Interviews were audio-recorded 
      and transcribed. Data were coded and analyzed using NVivo 12 software and a 
      Grounded Theory approach. Most HCPs welcomed an implant option for CLWH. 
      Perceived benefits included fewer clinic visits, improved adherence, and 
      "normalization" of the lives of CLWH. Concerns included painful insertion and 
      removal, the potential for stigmatization, and caregivers' likely rejection of 
      biodegradable implants. A single, small, non-transparent rod with some 
      flexibility was preferred by most participants. HCP training and early outreach 
      to mitigate potential misinformation about implants and caregivers' fears about 
      biodegradable implants were emphasized. Further engagement with caregivers of 
      CLWH is required and ongoing.
FAU - Scorgie, Fiona
AU  - Scorgie F
AUID- ORCID: 0000-0003-2560-8234
AD  - Wits RHI, Faculty of Health Sciences, University of the Witwatersrand, 
      Johannesburg, South Africa.
FAU - Hawley, Imogen
AU  - Hawley I
AD  - Women's Global Health Imperative, RTI International, Berkeley, California, USA.
FAU - Fairlie, Lee
AU  - Fairlie L
AD  - Wits RHI, Faculty of Health Sciences, University of the Witwatersrand, 
      Johannesburg, South Africa.
FAU - Pahad, Shenaaz
AU  - Pahad S
AD  - Wits RHI, Faculty of Health Sciences, University of the Witwatersrand, 
      Johannesburg, South Africa.
FAU - Mathebula, Florence
AU  - Mathebula F
AD  - Wits RHI, Faculty of Health Sciences, University of the Witwatersrand, 
      Johannesburg, South Africa.
FAU - Mohuba, Rebone
AU  - Mohuba R
AD  - Wits RHI, Faculty of Health Sciences, University of the Witwatersrand, 
      Johannesburg, South Africa.
FAU - London, Sarah-Jane
AU  - London SJ
AD  - Wits RHI, Faculty of Health Sciences, University of the Witwatersrand, 
      Johannesburg, South Africa.
FAU - Cottrell, Mackenzie L
AU  - Cottrell ML
AD  - UNC Eshelman School of Pharmacy, Chapel Hill, North Carolina, USA.
FAU - Johnson, Leah M
AU  - Johnson LM
AD  - RTI International, Research Triangle Park, North Carolina, USA.
FAU - Montgomery, Elizabeth T
AU  - Montgomery ET
AD  - Women's Global Health Imperative, RTI International, Berkeley, California, USA.
LA  - eng
GR  - R33 AI149499/AI/NIAID NIH HHS/United States
GR  - R61 AI149499/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - AIDS Patient Care STDS
JT  - AIDS patient care and STDs
JID - 9607225
SB  - IM
MH  - Child
MH  - Humans
MH  - Child, Preschool
MH  - *HIV Infections/drug therapy
MH  - South Africa
MH  - Health Personnel
MH  - Caregivers
MH  - Attitude of Health Personnel
MH  - Qualitative Research
PMC - PMC9595609
OTO - NOTNLM
OT  - HIV treatment
OT  - health care providers
OT  - implants
OT  - pediatric populations
OT  - qualitative end-user research
COIS- No competing financial interests exist.
EDAT- 2022/10/27 06:00
MHDA- 2022/10/29 06:00
PMCR- 2023/10/01
CRDT- 2022/10/26 09:22
PHST- 2022/10/26 09:22 [entrez]
PHST- 2022/10/27 06:00 [pubmed]
PHST- 2022/10/29 06:00 [medline]
PHST- 2023/10/01 00:00 [pmc-release]
AID - 10.1089/apc.2022.0087 [pii]
AID - 10.1089/apc.2022.0087 [doi]
PST - ppublish
SO  - AIDS Patient Care STDS. 2022 Oct;36(10):389-395. doi: 10.1089/apc.2022.0087.