PMID- 36286759
OWN - NLM
STAT- MEDLINE
DCOM- 20221028
LR  - 20221028
IS  - 0040-3660 (Print)
IS  - 0040-3660 (Linking)
VI  - 94
IP  - 9
DP  - 2022 Oct 24
TI  - [The effectiveness of cardiac contractility modulation in patients with chronic 
      heart failure and atrial fibrillation: results of the 12-month follow-up].
PG  - 1078-1084
LID - 10.26442/00403660.2022.09.201840 [doi]
AB  - AIM: To evaluate the efficacy, safety and effect on the prognosis of cardiac 
      contractility modulation (CCM) in patients with chronic heart failure (CHF) with 
      reduced left ventricular ejection fraction and atrial fibrillation compared with 
      the group of only optimal drug therapy (ODT) of the 12-month follow-up. MATERIALS 
      AND METHODS: Patients (n=200) were sequentially included in two groups: group 1 
      patients with CHF who are on ODT in combination with implanted CCM devices 
      (n=100), group 2 comparison patients with CHF who receive only ODT (n=100). 
      Initially and after 12 months, 12-channel electrocardiography (ECG), 
      transthoracic echocardiography, daily ECG-monitoring, determination of the level 
      of NT-proBNP, a six-minute walk test and an assessment of the quality of life 
      according to the Minnesota Questionnaire were performed. RESULTS: In the CCM 
      therapy group, a significant clinical improvement was revealed, which was 
      expressed in the form of a decrease in functional class CHF by NYHA (New York 
      Heart Association), an increase in the distance of a six-minute walk test and an 
      improvement in the quality of life according to Minnesota Questionnaire, as well 
      as an improvement in left ventricle contractile function compared to the ODT 
      group. The absence of a proarrhythmogenic effect of the CCM was shown. There was 
      a significant decrease in the frequency of the readmission due to CHF and the 
      probability of achieving the combined endpoint in the CCM therapy group compared 
      with only ODT. CONCLUSION: The use of CCM in patients with CHF and atrial 
      fibrillation is an effective and safe method of therapy that leads to the 
      development of reverse remodeling of the myocardium, improves the clinical status 
      of patients and reduces the frequency of readmission due to decompensation of 
      CHF.
FAU - Safiullina, A A
AU  - Safiullina AA
AUID- ORCID: 0000-0003-3483-4698
AD  - Chazov National Medical Research Center of Cardiology.
FAU - Uskach, T M
AU  - Uskach TM
AUID- ORCID: 0000-0003-4318-0315
AD  - Chazov National Medical Research Center of Cardiology.
FAU - Sapelnikov, O V
AU  - Sapelnikov OV
AUID- ORCID: 0000-0002-5186-2474
AD  - Chazov National Medical Research Center of Cardiology.
FAU - Grishin, I R
AU  - Grishin IR
AUID- ORCID: 0000-0002-2689-2751
AD  - Chazov National Medical Research Center of Cardiology.
FAU - Cherkashin, D I
AU  - Cherkashin DI
AUID- ORCID: 0000-0003-1679-1719
AD  - Chazov National Medical Research Center of Cardiology.
FAU - Amanatova, V A
AU  - Amanatova VA
AUID- ORCID: 0000-0002-0678-9538
AD  - Chazov National Medical Research Center of Cardiology.
FAU - Akchurin, R S
AU  - Akchurin RS
AUID- ORCID: 0000-0002-6726-4612
AD  - Chazov National Medical Research Center of Cardiology.
FAU - Tereshchenko, S N
AU  - Tereshchenko SN
AUID- ORCID: 0000-0001-9234-6129
AD  - Chazov National Medical Research Center of Cardiology.
LA  - rus
PT  - English Abstract
PT  - Journal Article
DEP - 20221024
PL  - Russia (Federation)
TA  - Ter Arkh
JT  - Terapevticheskii arkhiv
JID - 2984818R
SB  - IM
MH  - Humans
MH  - Stroke Volume
MH  - *Atrial Fibrillation/diagnosis/therapy
MH  - Ventricular Function, Left
MH  - Quality of Life
MH  - Follow-Up Studies
MH  - *Heart Failure/diagnosis/therapy
MH  - Chronic Disease
MH  - Treatment Outcome
OTO - NOTNLM
OT  - atrial fibrillation
OT  - cardiac contractility modulation
OT  - chronic heart failure with reduced left ventricular ejection fraction
OT  - quality of life
OT  - remodeling of the myocardium
EDAT- 2022/10/27 06:00
MHDA- 2022/10/29 06:00
CRDT- 2022/10/26 09:54
PHST- 2022/10/22 00:00 [received]
PHST- 2022/10/22 00:00 [accepted]
PHST- 2022/10/26 09:54 [entrez]
PHST- 2022/10/27 06:00 [pubmed]
PHST- 2022/10/29 06:00 [medline]
AID - 10.26442/00403660.2022.09.201840 [doi]
PST - epublish
SO  - Ter Arkh. 2022 Oct 24;94(9):1078-1084. doi: 10.26442/00403660.2022.09.201840.