PMID- 36286941
OWN - NLM
STAT- MEDLINE
DCOM- 20221028
LR  - 20221028
IS  - 0040-3660 (Print)
IS  - 0040-3660 (Linking)
VI  - 94
IP  - 7
DP  - 2022 Aug 12
TI  - [Prevalence and clinical associations of iron deficiency in patients with 
      decompensated heart failure, depending on the diagnostic criteria used for iron 
      deficiency].
PG  - 844-849
LID - 10.26442/00403660.2022.07.201716 [doi]
AB  - AIM: To compare the frequency of iron deficiency (ID) in patients with 
      decompensated heart failure (HF), defined by international guideline criterion 
      ferritin 100 ng/ml or ferritin from 100 to 299 ng/ml with TSAT20% (criterion A) 
      and by bone marrow biopsy criterion TSAT19.8% and serum iron 13 mol/l (criterion 
      B); to evaluate the effect of ID, diagnosed on the basis of different ID 
      criteria, on NT pro-BNP, sST2, CRP levels and New York Heart Association (NYHA) 
      functional classes (FC) distribution between groups with ID and without ID. 
      MATERIALS AND METHODS: The study included 223 patients (median age 73 [65; 82] 
      years, 58% males) who were hospitalized to V.V. Vinogradov Moscow City Clinical 
      Hospital No. 64 with decompensated HF. All patients underwent a standard 
      physiological examination, laboratory and instrumental studies, including 
      determination of NT-proBNP, sST2, CRP, and ferrokinetic parameters (serum iron, 
      transferrin, ferritin). TSAT was calculated as: serum iron / transferrin 3.98. 
      NYHA FC was determined according to Heart Failure Severity Rating Scale score. 
      All patients underwent echocardiography to assess the ejection fraction of the 
      left ventricle. RESULTS: According to criterion A ID was detected in 89% (n=199) 
      of patients. There were no significant differences between levels of CRP, 
      NT-proBNP and sST2. According to criterion B ID was detected in 70% (n=156) of 
      patients. In the ID group, higher levels of CRP (15.1 mg/l vs 6.2 mg/l, p0.001), 
      NT-proBNP (5422 pg/ml vs 2380 pg/ml, p0.001) and sST2 (59.6 ng/ml vs 42 ng/ml, 
      p=0.02) were detected. Intravenous FCM admission according to current 
      international guidelines (diagnosis of ID according to criterion A) is 
      recommended to 57% of patients included in this study. Both methods formed groups 
      with ID, in which patients had higher NYHA FC compared to groups without ID. 
      According to current clinical guidelines, iron deficiency should be assessed 
      according to method 1. More than half of patients (57, n=127) have indications 
      for intravenous FCM to reduce risk of HF hospitalizations. CONCLUSION: The 
      frequency of ID in patients with decompensated heart failure varies from 70 to 
      89% depending on the criterion used to diagnose ID, but in any case, remains 
      high. Intravenous FCM should be prescribed in 57% (n=127) of patients. Criterion 
      B, validated against the gold standard of diagnostics, unlike criterion A, makes 
      it possible to form groups of patients with ID and without ID, significantly 
      differing in CRP, NT-proBNP, and sST2 levels.
FAU - Kobalava, Z D
AU  - Kobalava ZD
AUID- ORCID: 0000-0002-5873-1768
AD  - People's Friendship University of Russia (RUDN University).
FAU - Lapshin, A A
AU  - Lapshin AA
AUID- ORCID: 0000-0002-4308-4764
AD  - People's Friendship University of Russia (RUDN University).
FAU - Tolkacheva, V V
AU  - Tolkacheva VV
AUID- ORCID: 0000-0001-6847-8797
AD  - People's Friendship University of Russia (RUDN University).
FAU - Galochkin, S A
AU  - Galochkin SA
AUID- ORCID: 0000-0001-7370-8606
AD  - People's Friendship University of Russia (RUDN University).
LA  - rus
PT  - English Abstract
PT  - Journal Article
DEP - 20220812
PL  - Russia (Federation)
TA  - Ter Arkh
JT  - Terapevticheskii arkhiv
JID - 2984818R
RN  - 0 (Biomarkers)
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
RN  - 0 (Peptide Fragments)
RN  - 9007-73-2 (Ferritins)
RN  - E1UOL152H7 (Iron)
RN  - 0 (Transferrins)
SB  - IM
MH  - Male
MH  - Humans
MH  - Aged
MH  - Female
MH  - *Iron Deficiencies
MH  - Prevalence
MH  - Prognosis
MH  - Biomarkers
MH  - Natriuretic Peptide, Brain
MH  - *Heart Failure/diagnosis/epidemiology/complications
MH  - Peptide Fragments
MH  - Ferritins
MH  - Iron
MH  - Transferrins
OTO - NOTNLM
OT  - CRP
OT  - NT-proBNP
OT  - acute decompensated heart failure
OT  - iron deficiency
OT  - sST2
EDAT- 2022/10/27 06:00
MHDA- 2022/10/29 06:00
CRDT- 2022/10/26 09:56
PHST- 2022/03/28 00:00 [received]
PHST- 2022/10/26 09:56 [entrez]
PHST- 2022/10/27 06:00 [pubmed]
PHST- 2022/10/29 06:00 [medline]
AID - 10.26442/00403660.2022.07.201716 [doi]
PST - epublish
SO  - Ter Arkh. 2022 Aug 12;94(7):844-849. doi: 10.26442/00403660.2022.07.201716.