PMID- 36287128
OWN - NLM
STAT- MEDLINE
DCOM- 20230202
LR  - 20230223
IS  - 1469-7793 (Electronic)
IS  - 0022-3751 (Linking)
VI  - 601
IP  - 3
DP  - 2023 Feb
TI  - Rat resistance to rheumatoid arthritis induction as a function of the early-phase 
      adrenal-pineal crosstalk.
PG  - 535-549
LID - 10.1113/JP283456 [doi]
AB  - Chronic inflammatory diseases are triggered by causal stimuli that might occur 
      long before the appearance of the symptoms. Increasing evidence suggests that 
      these stimuli are necessary but not always sufficient to induce the diseases. The 
      murine model of type II collagen emulsified in Freund's incomplete adjuvant 
      (collagen-induced arthritis) to induce rheumatoid arthritis (RA) follows this 
      pattern as some animals do not develop the chronically inflamed phenotype. 
      Considering that in the immune-pineal axis (IPA) theory adrenal-pineal cross-talk 
      adjusts early phases of inflammatory processes, we investigated whether 
      differences in IPA activation could explain why some animals are resistant (RES) 
      while others develop RA. We observed a similar increase in 6-sulfatoxymelatonin 
      (aMT6s) excretion from day 3 to 13 in both RES and RA animals, followed by a 
      significant decrease in RA animals. This pattern of aMT6s excretion positively 
      correlated with plasma corticosterone (CORT) in RES animals. Additionally, RA 
      animals presented a lower aMT6s/CORT ratio than saline-injected or RES animals. 
      Plasmatic levels of tumour necrosis factor were similar in both groups, but 
      interleukin (IL)-1beta and monocyte chemotactic protein 1 (MCP-1) levels were lower 
      in RES compared to RA animals. IL-2 and IL-4 were decreased in RES animals 
      compared to saline-injected animals. The aMT6s/CORT ratio inversely correlated 
      with the paw thickness and the inflammatory score (levels of IL-1beta, MCP-1, IL-2 
      and IL-4 combined). Thus, adrenocortical-pineal positive interaction is an early 
      defence mechanism for avoiding inflammatory chronification. KEY POINTS: 
      Immune-pineal axis imbalance is observed in early-phase rheumatoid arthritis 
      development. Only resistant animals present a positive association between 
      adrenal and pineal hormones. The 6-sulfatoxymelatonin/corticosterone ratio is 
      decreased in animals that develop rheumatoid arthritis. The inflammatory score 
      combining the levels of nocturnal interleukin (IL)-1beta, monocyte chemotactic 
      protein 1, IL-2 and IL-4 presents a very strong positive correlation with the 
      size of inflammatory lesion. The 6-sulfatoxymelatonin/corticosterone ratio 
      presents a strong negative correlation with the inflammatory score and paw oedema 
      size.
CI  - (c) 2022 The Authors. The Journal of Physiology (c) 2022 The Physiological Society.
FAU - Cordoba-Moreno, Marlina O
AU  - Cordoba-Moreno MO
AUID- ORCID: 0000-0001-8055-0085
AD  - Department of Physiology, University of Sao Paulo, Sao Paulo, Sao Paulo, Brazil.
FAU - Mendes, Mariana Trivilin
AU  - Mendes MT
AD  - Department of Physiology, University of Sao Paulo, Sao Paulo, Sao Paulo, Brazil.
FAU - Markus, Regina P
AU  - Markus RP
AUID- ORCID: 0000-0003-4606-6120
AD  - Department of Physiology, University of Sao Paulo, Sao Paulo, Sao Paulo, Brazil.
FAU - Fernandes, Pedro Augusto
AU  - Fernandes PA
AUID- ORCID: 0000-0002-4871-8201
AD  - Department of Physiology, University of Sao Paulo, Sao Paulo, Sao Paulo, Brazil.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20221208
PL  - England
TA  - J Physiol
JT  - The Journal of physiology
JID - 0266262
RN  - 0 (Chemokine CCL2)
RN  - W980KJ009P (Corticosterone)
RN  - 207137-56-2 (Interleukin-4)
RN  - 0 (Interleukin-2)
RN  - 0 (Cytokines)
SB  - IM
CIN - J Physiol. 2023 Feb;601(3):403-405. PMID: 36550630
MH  - Rats
MH  - Mice
MH  - Animals
MH  - Chemokine CCL2
MH  - Corticosterone
MH  - Interleukin-4/adverse effects
MH  - Interleukin-2
MH  - *Arthritis, Rheumatoid/metabolism/pathology
MH  - *Arthritis, Experimental/chemically induced/pathology
MH  - Cytokines/metabolism
OTO - NOTNLM
OT  - chronic inflammation
OT  - collagen-induced arthritis
OT  - cytokines
OT  - glucocorticoids
OT  - immune-pineal axis
OT  - melatonin
OT  - rheumatoid arthritis
EDAT- 2022/10/27 06:00
MHDA- 2023/02/03 06:00
CRDT- 2022/10/26 10:33
PHST- 2022/06/10 00:00 [received]
PHST- 2022/10/07 00:00 [accepted]
PHST- 2022/10/27 06:00 [pubmed]
PHST- 2023/02/03 06:00 [medline]
PHST- 2022/10/26 10:33 [entrez]
AID - 10.1113/JP283456 [doi]
PST - ppublish
SO  - J Physiol. 2023 Feb;601(3):535-549. doi: 10.1113/JP283456. Epub 2022 Dec 8.