PMID- 36288883
OWN - NLM
STAT- MEDLINE
DCOM- 20221031
LR  - 20221031
IS  - 1791-7530 (Electronic)
IS  - 0250-7005 (Linking)
VI  - 42
IP  - 11
DP  - 2022 Nov
TI  - Interleukin-18 (IL-18) Cytokine Serum Concentrations Correlate With Pain Scores 
      and the Number of Analgesic Doses Following Surgery.
PG  - 5521-5526
LID - 10.21873/anticanres.16057 [doi]
AB  - BACKGROUND/AIM: Anti- and proinflammatory cytokines and plasma high-sensitivity 
      C-reactive protein (hs-CRP) are used to assess inflammatory stress response (ISR) 
      following surgery. However, the serum IL-18 (interleukin-18) cytokine values 
      versus numeric rating scale (NRS) pain score and number of analgesic doses (NAD) 
      postoperatively are unknown. PATIENTS AND METHODS: Blood levels of six 
      interleukins (IL-18, IL-1ra, IL-6, IL-10, IL-1beta, and IL-8) and hs-CRP were 
      measured at three time points; before operation (PRE), immediately after 
      operation (POP1), and six hours after operation (POP2) in 114 patients with 
      cholelithiasis. RESULTS: Following surgery, the blood levels of hs-CRP and 
      IL-1ra, IL-6, IL-10, and IL-1beta cytokines had a trend for increase (p<0.001 and 
      p=0.014, respectively). The serum IL-18 concentrations inversely correlated to 
      NRS and NAD during the first 24 h postoperatively. CONCLUSION: The correlation of 
      IL-18 levels to NRS and NAD values supports the hypothesis that ISR and pain are 
      related.
CI  - Copyright (c) 2022 International Institute of Anticancer Research (Dr. George J. 
      Delinasios), All rights reserved.
FAU - Eskelinen, Maaret
AU  - Eskelinen M
AD  - Department of Surgery, Kuopio University Hospital (KUH) and School of Medicine, 
      University of Eastern Finland (UEF), Kuopio, Finland.
FAU - Saimanen, Iina
AU  - Saimanen I
AD  - Department of Surgery, Kuopio University Hospital (KUH) and School of Medicine, 
      University of Eastern Finland (UEF), Kuopio, Finland.
FAU - Selander, Tuomas
AU  - Selander T
AD  - Department of Science Service Center, Kuopio University Hospital (KUH) and School 
      of Medicine, University of Eastern Finland (UEF), Kuopio, Finland.
FAU - Holopainen, Anu
AU  - Holopainen A
AD  - Department of Clinical Chemistry, UEF and Eastern Finland Laboratory Centre 
      (ISLAB), KUH, Kuopio, Finland.
FAU - Aspinen, Samuli
AU  - Aspinen S
AD  - Department of Surgery, Kuopio University Hospital (KUH) and School of Medicine, 
      University of Eastern Finland (UEF), Kuopio, Finland.
FAU - Hamalainen, Esa
AU  - Hamalainen E
AD  - Department of Clinical Chemistry, UEF and Eastern Finland Laboratory Centre 
      (ISLAB), KUH, Kuopio, Finland.
FAU - Eskelinen, Matti
AU  - Eskelinen M
AD  - Department of Surgery, Kuopio University Hospital (KUH) and School of Medicine, 
      University of Eastern Finland (UEF), Kuopio, Finland; matti.eskelinen@kuh.fi.
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
RN  - 0 (Analgesics)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - 0 (Cytokines)
RN  - 0 (Interleukin 1 Receptor Antagonist Protein)
RN  - 130068-27-8 (Interleukin-10)
RN  - 0 (Interleukin-18)
RN  - 0 (Interleukin-6)
RN  - 0 (Interleukin-8)
RN  - 0 (Interleukins)
RN  - 0U46U6E8UK (NAD)
SB  - IM
MH  - Humans
MH  - Analgesics/therapeutic use
MH  - C-Reactive Protein/analysis
MH  - *Cytokines
MH  - Interleukin 1 Receptor Antagonist Protein
MH  - Interleukin-10
MH  - *Interleukin-18
MH  - Interleukin-6
MH  - Interleukin-8
MH  - Interleukins
MH  - NAD
MH  - Pain
MH  - *Pain, Postoperative/diagnosis
OTO - NOTNLM
OT  - Cholelithiasis
OT  - IL-18
OT  - NRS pain score
OT  - analgesic doses
OT  - surgery
EDAT- 2022/10/27 06:00
MHDA- 2022/10/29 06:00
CRDT- 2022/10/26 20:53
PHST- 2022/08/12 00:00 [received]
PHST- 2022/08/30 00:00 [revised]
PHST- 2022/09/05 00:00 [accepted]
PHST- 2022/10/26 20:53 [entrez]
PHST- 2022/10/27 06:00 [pubmed]
PHST- 2022/10/29 06:00 [medline]
AID - 42/11/5521 [pii]
AID - 10.21873/anticanres.16057 [doi]
PST - ppublish
SO  - Anticancer Res. 2022 Nov;42(11):5521-5526. doi: 10.21873/anticanres.16057.