PMID- 36289536
OWN - NLM
STAT- MEDLINE
DCOM- 20221028
LR  - 20221030
IS  - 1472-6823 (Electronic)
IS  - 1472-6823 (Linking)
VI  - 22
IP  - 1
DP  - 2022 Oct 26
TI  - Association between triglyceride-glucose index and nonalcoholic fatty liver 
      disease in type 2 diabetes mellitus.
PG  - 261
LID - 10.1186/s12902-022-01172-7 [doi]
LID - 261
AB  - BACKGROUND: Lipid and glucose metabolism abnormalities are associated with 
      nonalcoholic fatty liver disease (NAFLD). The triglyceride-glucose (TyG) index is 
      a recently developed indicator that can identify individuals at risk for NAFLD. 
      However, the applicability of the TyG index for identifying NAFLD in patients 
      with type 2 diabetes mellitus (T2DM) is unclear. The aim of this study was to 
      investigate the ability of the TyG index to identify individuals at risk for 
      NAFLD in the T2DM population. METHODS: A total of 2280 participants with T2DM 
      were recruited in this cross-sectional study. The TyG index was calculated, and 
      NAFLD was diagnosed by ultrasonography. Binary logistic regression models were 
      used to evaluate the association of the TyG index, glycemic parameters and lipid 
      parameters with NAFLD. RESULTS: Logistic regression analysis showed that the TyG 
      index was significantly associated with NAFLD in subjects with T2DM, the odds 
      ratio (OR) were 3.27 (95% confidence interval [CI], 2.03-5.27; P < 0.001) for 
      NAFLD in the highest TyG quartile after adjustment for known confounders. In 
      stratified analysis, an elevated TyG index were more remarkably associated with 
      NAFLD in younger patients (< 65 years; OR, 2.35; 95% CI, 1.83-3.02; P < 0.001), 
      females (OR, 2.69; 95% CI, 1.67-4.32; P < 0.001), patients with BMI < 25 kg/m(2) 
      (OR, 2.80; 95% CI, 2.01-3.91; P < 0.0001), and with lower high-density 
      lipoprotein cholesterol (< 1 mmol/L; OR, 2.76; 95% CI, 1.98-3.83; P < 0.001). 
      CONCLUSION: The TyG index is significantly associated with NAFLD and shows 
      superior ability for identify NAFLD risk compared with other lipid and glycemic 
      parameters in T2DM.
CI  - (c) 2022. The Author(s).
FAU - Li, Wei
AU  - Li W
AD  - Department of Rheumatology, The First Affiliated Hospital of Zhengzhou 
      University, NO. 1, Jianshe East Road, 450052, Zhengzhou, Henan Province, China.
FAU - Wang, Yan
AU  - Wang Y
AD  - Department of Respiratory and Critical Care Medicine, The First Affiliated 
      Hospital of Zhengzhou University, NO. 1, Jianshe East Road, 450052, Zhengzhou, 
      Henan Province, China.
FAU - He, Feng
AU  - He F
AD  - Department of Biochemistry and Immunology, Capital Institute of Pediatrics, NO. 
      2, Yabao Road, Chaoyang District, 100020, Beijing, China.
FAU - Liu, Zhuo
AU  - Liu Z
AD  - Department of Biochemistry and Immunology, Capital Institute of Pediatrics, NO. 
      2, Yabao Road, Chaoyang District, 100020, Beijing, China.
FAU - Dong, Jie
AU  - Dong J
AD  - Pediatrics Research Institute of Hunan Province, Hunan Children's Hospital, 
      Changsha, China.
FAU - Zhang, Yuqi
AU  - Zhang Y
AD  - Department of Rheumatology, The First Affiliated Hospital of Zhengzhou 
      University, NO. 1, Jianshe East Road, 450052, Zhengzhou, Henan Province, China.
FAU - Li, Tianfang
AU  - Li T
AD  - Department of Rheumatology, The First Affiliated Hospital of Zhengzhou 
      University, NO. 1, Jianshe East Road, 450052, Zhengzhou, Henan Province, China.
FAU - Liu, Shengyun
AU  - Liu S
AD  - Department of Rheumatology, The First Affiliated Hospital of Zhengzhou 
      University, NO. 1, Jianshe East Road, 450052, Zhengzhou, Henan Province, China. 
      fccliusy2@zzu.edu.cn.
FAU - Chen, En
AU  - Chen E
AD  - Department of Laboratory Medicine, The First Affiliated Hospital, Hengyang 
      Medical School, University of South China, 421001, Hengyang, Hunan Province, 
      China. cheneng3821@sina.com.
LA  - eng
GR  - 82000831/National Natural Science Foundation of China/
PT  - Journal Article
DEP - 20221026
PL  - England
TA  - BMC Endocr Disord
JT  - BMC endocrine disorders
JID - 101088676
RN  - 0 (Triglycerides)
RN  - IY9XDZ35W2 (Glucose)
RN  - 0 (Blood Glucose)
RN  - 0 (Cholesterol, HDL)
SB  - IM
MH  - Female
MH  - Humans
MH  - Triglycerides
MH  - *Non-alcoholic Fatty Liver Disease/complications/epidemiology
MH  - *Diabetes Mellitus, Type 2/complications/diagnosis
MH  - Glucose
MH  - Cross-Sectional Studies
MH  - Blood Glucose/metabolism
MH  - Cholesterol, HDL
MH  - Risk Factors
PMC - PMC9597972
OTO - NOTNLM
OT  - BMI
OT  - Glycemic parameters
OT  - Lipid parameters
OT  - NAFLD
OT  - T2DM
OT  - TyG index
COIS- The authors declare that they have no competing interests.
EDAT- 2022/10/28 06:00
MHDA- 2022/10/29 06:00
PMCR- 2022/10/26
CRDT- 2022/10/27 00:20
PHST- 2022/05/10 00:00 [received]
PHST- 2022/10/04 00:00 [accepted]
PHST- 2022/09/24 00:00 [revised]
PHST- 2022/10/27 00:20 [entrez]
PHST- 2022/10/28 06:00 [pubmed]
PHST- 2022/10/29 06:00 [medline]
PHST- 2022/10/26 00:00 [pmc-release]
AID - 10.1186/s12902-022-01172-7 [pii]
AID - 1172 [pii]
AID - 10.1186/s12902-022-01172-7 [doi]
PST - epublish
SO  - BMC Endocr Disord. 2022 Oct 26;22(1):261. doi: 10.1186/s12902-022-01172-7.