PMID- 36289669
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230308
IS  - 2227-9059 (Print)
IS  - 2227-9059 (Electronic)
IS  - 2227-9059 (Linking)
VI  - 10
IP  - 10
DP  - 2022 Sep 26
TI  - Noninvasive Hemodynamic Monitoring in Advanced Heart Failure Patients: New 
      Approach for Target Treatments.
LID - 10.3390/biomedicines10102407 [doi]
LID - 2407
AB  - Using bio-impedance to deduce some hemodynamic parameters combined with some 
      short-term ECG temporal dispersion intervals, and measuring myocardial 
      depolarization, intraventricular conduction, and repolarization. A total of 65 
      in-hospital patients (M/F:35/30) were enrolled, 39 with HFrEF and 26 HFpEF, in 
      New York Heart Association (NYHA) class IV. Stroke volume (SVI), cardiac indexes 
      (CI), left ventricular ejection fraction (LVEFBIO), end diastolic volume 
      (LV-EDV), and other systolic and diastolic parameters were noninvasively obtained 
      at enrollment and at hospital discharge. At the same time, QR, QRS, QT, ST, 
      Tpeak-Tend (Te) interval mean, and standard deviation (SD) from 5 min ECG 
      recordings were obtained. At baseline, HFrEF patients reported significantly 
      lower SVI (p < 0.05), CI (p < 0.05), and LVEF (p < 0.001) than HFpEF patients; 
      moreover, HFrEF patients also showed increased LV-EDV (p < 0.05), QR, QRS, QT, 
      ST, and Te means (p < 0.05) and standard deviations (p < 0.05) in comparison to 
      HFpEF subjects. Multivariable logistic regression analysis reported a significant 
      correlation between hospital mortality and Te mean (odds ratio: 1.03, 95% 
      confidence limit: 1.01-1.06, p: 0.01). Fifty-seven percent of patients were 
      considered responders to optimal medical therapy and, at discharge, they had 
      significantly reduced NT-proBNP, (p < 0.001), heart rate (p < 0.05), and TeSD (p 
      < 0.001). LVEF, obtained by transthoracic echocardiography, and LVEFBIO were 
      significantly related (r: 0.781, p < 0.001), but these two parameters showed a 
      low agreement limit. Noninvasive hemodynamic and ECG-derived parameters were 
      useful to highlight the difference between HFrEF and HFpEF and between responders 
      and nonresponders to the optimal medical therapy. Short-period bioimpedance and 
      electrocardiographic data should be deeply evaluated to determine possible 
      advantages in the therapeutic and prognostic approach in severe CHF.
FAU - Piccirillo, Gianfranco
AU  - Piccirillo G
AD  - Department of Internal and Clinical Medicine, Anesthesiology and Cardiovascular 
      Sciences, Policlinico Umberto I, "Sapienza" University of Rome, Viale del 
      Policlinico n. 155, 00186 Rome, Italy.
FAU - Moscucci, Federica
AU  - Moscucci F
AUID- ORCID: 0000-0002-9385-9097
AD  - Department of Internal and Clinical Medicine, Anesthesiology and Cardiovascular 
      Sciences, Policlinico Umberto I, "Sapienza" University of Rome, Viale del 
      Policlinico n. 155, 00186 Rome, Italy.
FAU - Corrao, Andrea
AU  - Corrao A
AD  - Department of Internal and Clinical Medicine, Anesthesiology and Cardiovascular 
      Sciences, Policlinico Umberto I, "Sapienza" University of Rome, Viale del 
      Policlinico n. 155, 00186 Rome, Italy.
FAU - Carnovale, Myriam
AU  - Carnovale M
AD  - Department of Internal and Clinical Medicine, Anesthesiology and Cardiovascular 
      Sciences, Policlinico Umberto I, "Sapienza" University of Rome, Viale del 
      Policlinico n. 155, 00186 Rome, Italy.
FAU - Di Diego, Ilaria
AU  - Di Diego I
AD  - Department of Internal and Clinical Medicine, Anesthesiology and Cardiovascular 
      Sciences, Policlinico Umberto I, "Sapienza" University of Rome, Viale del 
      Policlinico n. 155, 00186 Rome, Italy.
FAU - Lospinuso, Ilaria
AU  - Lospinuso I
AD  - Department of Internal and Clinical Medicine, Anesthesiology and Cardiovascular 
      Sciences, Policlinico Umberto I, "Sapienza" University of Rome, Viale del 
      Policlinico n. 155, 00186 Rome, Italy.
FAU - Caltabiano, Cristina
AU  - Caltabiano C
AD  - Department of Internal and Clinical Medicine, Anesthesiology and Cardiovascular 
      Sciences, Policlinico Umberto I, "Sapienza" University of Rome, Viale del 
      Policlinico n. 155, 00186 Rome, Italy.
FAU - Mezzadri, Martina
AU  - Mezzadri M
AD  - Department of Internal and Clinical Medicine, Anesthesiology and Cardiovascular 
      Sciences, Policlinico Umberto I, "Sapienza" University of Rome, Viale del 
      Policlinico n. 155, 00186 Rome, Italy.
FAU - Rossi, Pietro
AU  - Rossi P
AD  - Arrhytmology Unit, Cardiology Division, S. Giovanni Calibita, Isola Tiberina, 
      00186 Rome, Italy.
FAU - Magri, Damiano
AU  - Magri D
AD  - Department of Clinical and Molecular Medicine, S. Andrea Hospital, "Sapienza" 
      University of Rome, 00186 Rome, Italy.
LA  - eng
PT  - Journal Article
DEP - 20220926
PL  - Switzerland
TA  - Biomedicines
JT  - Biomedicines
JID - 101691304
PMC - PMC9599112
OTO - NOTNLM
OT  - QT
OT  - QT variability
OT  - Tpeak-Tend
OT  - advanced heart failure
OT  - bioimpedance cardiography
OT  - mortality
OT  - temporal dispersion of repolarization phase
COIS- Authors deny personal or financial conflicts of interest regarding this paper.
EDAT- 2022/10/28 06:00
MHDA- 2022/10/28 06:01
PMCR- 2022/09/26
CRDT- 2022/10/27 01:01
PHST- 2022/07/15 00:00 [received]
PHST- 2022/09/21 00:00 [revised]
PHST- 2022/09/21 00:00 [accepted]
PHST- 2022/10/27 01:01 [entrez]
PHST- 2022/10/28 06:00 [pubmed]
PHST- 2022/10/28 06:01 [medline]
PHST- 2022/09/26 00:00 [pmc-release]
AID - biomedicines10102407 [pii]
AID - biomedicines-10-02407 [pii]
AID - 10.3390/biomedicines10102407 [doi]
PST - epublish
SO  - Biomedicines. 2022 Sep 26;10(10):2407. doi: 10.3390/biomedicines10102407.